Perinatal High-Salt Diet Induces Gut Microbiota Dysbiosis, Bile Acid Homeostasis Disbalance, and NAFLD in Weanling Mice Offspring

Guo, Qing; Tang, Yi; Liu, Ying; Xu, Ziyuan; Zhang, Di; Liu, Jiangtao; Wang, Xin; Xia, Wei; Xu, Shunqing

doi:10.3390/nu13072135

Cited by 21 publications

(19 citation statements)

References 68 publications

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“…Even the maternal dietary structure affects BA metabolism in offspring. When perinatal mice were fed a high-salt diet, their offspring showed greater changes in fecal microbial β-diversity, which further promoted a BA imbalance, increased intestinal barrier permeability and reduced hepatic FXR expression, thus promoting NAFLD ( Guo et al, 2021 ). Abnormal interactions of the microbiome, BA and FXR were involved in the occurrence of NAFLD.…”

Section: The Role Of Ba Metabolism In Nafldmentioning

confidence: 99%

The role of bile acid metabolism in the occurrence and development of NAFLD

Bing

2022

Front. Mol. Biosci.

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Non-alcoholic fatty liver disease (NAFLD) has become one of the important causes of cirrhosis and liver cancer, resulting in a huge medical burden worldwide. Currently, effective non-invasive diagnostic indicators and drugs for NAFLD are still lacking. With the development of metabolomics technology, the changes in metabolites during the development of NAFLD have been gradually revealed. Bile acid (BA) is the main endpoint of cholesterol metabolism in the body. In addition, it also acts as a signaling factor to regulate metabolism and inflammation in the body through the farnesyl X receptor and G protein-coupled BA receptor. Studies have shown that BA metabolism is associated with the development of NAFLD, but a large number of animal and clinical studies are still needed. BA homeostasis is maintained through multiple negative feedback loops and the enterohepatic circulation of BA. Recently, treatment of NAFLD by interfering with BA synthesis and metabolism has become a new research direction. Here, we review the changes in BA metabolism and its regulatory mechanisms during the development of NAFLD and describe the potential of studies exploring novel non-invasive diagnostic indicators and therapeutic targets for NAFLD based on BA metabolism.

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Section: The Role Of Ba Metabolism In Nafldmentioning

confidence: 99%

The role of bile acid metabolism in the occurrence and development of NAFLD

Bing

2022

Front. Mol. Biosci.

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“…It is well known that a high-salt diet leads to increased cardiovascular risk. Interestingly, high-salt diets have also been reported to cause imbalances in gut microbiota and metabolism of bile acid, thus leading to elevation of lipids ( 53 ). Another animal experiment found a high-salt diet causes elevated TMAO in the circulation and brain, leading to sympathetic arousal and increased blood pressure ( 54 ).…”

Section: Discussionmentioning

confidence: 99%

Coronary heart disease and gut microbiota: A bibliometric and visual analysis from 2002 to 2022

Liang

Mao

Zhang

et al. 2022

Front. Cardiovasc. Med.

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BackgroundExisting studies have indicated that gut microbiota is closely related to the occurrence and development of coronary heart disease(CHD). Gut microbiota and its metabolites may be important diagnostic markers for CHD in the future and are expected to become new targets for the prevention and treatment of CHD. However, the current studies exploring the link between CHD and gut microbiota are miscellaneous and poorly targeted, without bibliometric analysis available.ObjectiveThe purpose of this research was to perform a bibliometric and visual analysis of published papers on the relationship between CHD and gut microbiota. The study also sought to identify principal authors, institutions, and countries to analyze the research status and trends of gut microbiota research in the field of CHD.MethodsThe Web of Science Core Collection (WoSCC) database was searched for publications on CHD and gut microbiota between 2002 and 2022. CiteSpace 5.8. R1, VOSviewer 1.6.16, and Microsoft Excel 2019 software tools were utilized to perform this bibliometric analysis and visualization.ResultsThere were 457 qualified publications found in total, with the annual number of publications increasing. The United States dominated in this field. Hazen, Stanley l was the author of the most papers. Cleveland Clinic published the most papers of any institution. The six main clusters’ specific characteristics were discovered through analysis of the co-occurrence of keywords: inflammation, diet, trimethylamine n-oxide, metabolism, cardiovascular disease, and myocardial infarction. Newly emerging research has focused predominantly on gut microbiota metabolites and recent strategies for intervention in coronary atherosclerosis.ConclusionThese results provided a useful perspective on current research and future prospects for the research on the link between CHD and gut microbiota, which may help researchers to select suitable collaborators and facilitate their research to elucidate the underlying molecular mechanisms of CHD, including the causes, prevention, and treatment.

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“…The enterohepatic circulation functions to safely store and then promptly deliver BAs in high concentration to the intestinal lumen for digestion and absorption of lipids. The gut microbiota dysbiosis promoted BA homeostasis disbalance, characterized by the accumulation of LCA and DCA in feces ( Guo et al, 2021 ). Dysregulated expression of the ASBT and OSTα/β may lead to BA accumulation and injury in liver epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Medicinal Formula Huazhi-Rougan Attenuates Non-Alcoholic Steatohepatitis Through Enhancing Fecal Bile Acid Excretion in Mice

et al. 2022

Front. Pharmacol.

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Huazhi-Rougan (HZRG) formula is a Traditional Chinese medicine prescription, and has been widely used to treat non-alcoholic fatty liver disease (NAFLD) and its progressive form non-alcoholic steatohepatitis (NASH). However, the anti-NASH effects and the underlying mechanisms of HZRG have not yet been characterized. Here we showed that 4-week HZRG treatment alleviated methionine-choline-deficiency (MCD) diet-induced NASH in C57BL/6J mice, as evidenced by the improvement of hepatic steatosis and inflammation, as well as the decrease of serum levels of alanine and aspartate transaminases. Fecal 16S rDNA sequencing indicated that HZRG reduced the enrichment of pathogenic bacteria and increased the abundance of bacteria gena that are involved in bile acid (BA) conversation. The alteration of fecal and serum BA profile suggested that HZRG enhanced fecal BA excretion, and reduced the reabsorption of toxic secondary BA species (LCA, DCA, HCA). We further analyzed the BA receptors and transporters, and found that HZRG inhibited the expression of ileal bile acid transporter, and organic solute transporter subunit β, and increased the expression of intestinal tight junction proteins (ZO-1, Occludin, Claudin-2). The modulation of gut dysbiosis and BA profile, as well as the improvement of the intestinal environment, may contribute to the decrease of the p-65 subunit of NF-κB phosphorylation, liver F4/80 positive macrophages, inflammatory cytokine IL-1β and TNF-α expression. In conclusion, HZRG treatment enhances fecal BA excretion via inhibiting BA transporters, modulates BA profiles, gut dysbiosis as well as the intestinal environment, thus contributing to the beneficial effect of HZRG on NASH mice.

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Perinatal High-Salt Diet Induces Gut Microbiota Dysbiosis, Bile Acid Homeostasis Disbalance, and NAFLD in Weanling Mice Offspring

Cited by 21 publications

References 68 publications

The role of bile acid metabolism in the occurrence and development of NAFLD

The role of bile acid metabolism in the occurrence and development of NAFLD

Coronary heart disease and gut microbiota: A bibliometric and visual analysis from 2002 to 2022

Medicinal Formula Huazhi-Rougan Attenuates Non-Alcoholic Steatohepatitis Through Enhancing Fecal Bile Acid Excretion in Mice

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