Perinatal factors in patent ductus arteriosus in very low‐birthweight infants

Chen, Yingyao; Wang, Hsiao-Ping; Chang, Jenn-Tzong; Chiou, Yee-Hsuan; Huang, Ya-Ling; Hsieh, Kai‐Sheng

doi:10.1111/ped.12199

Cited by 18 publications

(22 citation statements)

References 22 publications

(48 reference statements)

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“…Meta-analysis could not detect a significant association between SPDA and platelet counts below 50 × 10 9 /l (RR = 1.123, 95% CI: 0.717-1.757, Z = 0.506, p = 0.613). Mean (SD) platelet counts in infants with and without SPDA were available from 5 cohorts [ [9,10,14,15] and CPS]. The pooled standard difference (no-SPDA minus SPDA) in means was not statistically significant (11.69 × 10 9 , 95% CI: -16.23 to 39.62, p = 0.412).…”

Section: Resultsmentioning

confidence: 99%

“…infants with a small PDA were included in the PDA group. Four studies [9,10,14,15] compared infants with and without SPDA, i.e. infants with a small PDA were included in the non-SPDA group.…”

Section: Resultsmentioning

confidence: 99%

“…After careful review, 8 full articles [7,9,10,12,13,14,15,18], 1 letter to the editor [11], and 1 abstract [19] were eligible for the meta-analysis. An additional unpublished cohort of 126 preterm infants was included in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…They reported that a platelet count between 101 and 140 × 10 9 /l on the first day of life was an independent predictor of PDA. Since the publication of this study, several additional cohorts have been reported with discordant results [9,10,11,12,13,14,15]. We performed a meta-analysis of all the studies reported to date addressing the association between platelet counts in the first day(s) of life and the presence of a PDA in preterm infants, in an attempt to clarify this issue.…”

Section: Introductionmentioning

confidence: 99%

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Platelet Counts and Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-Analysis

et al. 2015

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Background: Several cohort studies have shown an association between low platelet counts in the first day(s) of life and patent ductus arteriosus (PDA) in preterm infants. However, these results have not been confirmed by other studies. Objective: To perform a meta-analysis of all the studies addressing the relationship between platelet counts in the first day(s) of life and PDA in preterm infants. Methods: PubMed/MEDLINE and EMBASE were searched from their inception until December 2014. Results from 11 cohort studies involving 3,479 preterm infants (gestational age <32 weeks) were pooled using random-effects modeling. Results: Meta-analysis showed a significant positive association between PDA and platelet counts <150 × 10⁹/l [6 studies, risk ratio (RR) = 1.215, 95% CI: 1.027-1.436], between PDA and platelet counts <100 × 10⁹/l (5 studies, RR = 1.255, 95% CI: 1.034-1.525), and between significant PDA (SPDA) and platelet counts <100 × 10⁹/l (5 studies, RR = 1.254, 95% CI: 1.021-1.540). The association between SPDA and platelet counts <150 × 10⁹/l was not statistically significant (6 studies, RR = 1.289, 95% CI: 0.925-1.795). Pooled standard differences in mean platelet counts between infants with and without PDA/SPDA were not statistically different. Conclusion: This meta-analysis reveals a marginal but significant association between low platelet counts in the first day(s) of life and PDA/SPDA in very preterm infants. This association needs to be confirmed in prospective studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Platelet Counts and Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-Analysis

et al. 2015

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“…Gestational age, antenatal glucocorticoid exposure, respiratory distress syndrome (RDS), and race have been reported as independent risk factors affecting ductal closure [6,7,8]. In addition, some prior studies have shown that sPDA is highly familial.…”

Section: Introductionmentioning

confidence: 99%

Very Low Birth Weight Monochorionic Diamniotic Twins as a Risk Factor for Symptomatic Patent Ductus Arteriosus

Yamaguchi

Wada²,

Nagasawa³

et al. 2016

Neonatology

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Background: Some prior studies have shown that symptomatic patent ductus arteriosus (sPDA) is highly familial. Although it is estimated that both genetic and environmental factors may contribute to sPDA, evidence is still lacking. Objective: The aim of this study was to determine the risk factors for sPDA, focusing on the genetic and in utero environment by analyzing very low birth weight (VLBW) singletons and twins. Methods: This retrospective case-control study reviewed the medical records of 445 VLBW infants (25 weeks ≤ gestational age <32 weeks, 600 g ≤ birth weight <1,500 g) and compared the incidence of sPDA among monochorionic diamniotic (MD) twins (n = 65), dichorionic diamniotic (DD) twins (n = 66), and singletons (n = 314). Results: Stepwise multiple regression analysis showed that twin siblings (p = 0.001), gestational week (p < 0.001), antenatal steroid use (p = 0.021), and premature rupture of membranes (p = 0.002) were independent predictors of sPDA. Incidence of sPDA in MD twin siblings was significantly higher than that in singletons (p < 0.01), whereas no significant difference was found between singletons and DD twins or between MD and DD twins. Conclusions: The current results show that being a VLBW MD twin is an independent risk factor for sPDA, and that both genetic and in utero environmental factors may contribute to its development.

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The relationship between platelet indices and patent ductus arteriosus in preterm infants: a systematic review and meta-analysis

Ding

Zhang

et al. 2020

Eur J Pediatr

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Perinatal factors in patent ductus arteriosus in very low‐birthweight infants

Cited by 18 publications

References 22 publications

Platelet Counts and Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-Analysis

Platelet Counts and Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-Analysis

Very Low Birth Weight Monochorionic Diamniotic Twins as a Risk Factor for Symptomatic Patent Ductus Arteriosus

The relationship between platelet indices and patent ductus arteriosus in preterm infants: a systematic review and meta-analysis

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