Perinatal effect of methamphetamine on nociception in adult Wistar rats

Yamamotová, A; Hrubá, Lenka; Schutová, Barbora; Rokyta, Richard; Šlamberová, Romana

doi:10.1016/j.ijdevneu.2010.08.004

Cited by 23 publications

(16 citation statements)

References 66 publications

(70 reference statements)

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“…Our findings showing decreased analgesic effect on forelimbs and hind limbs but not the tail in prenatally MA-exposed relative to prenatally saline-exposed rats suggest long-term effect of prenatal MA exposure affecting especially supraspinal analgesic mechanisms (Zemlan et al, 1984;Roerig and Fujimoto, 1988). The anti-analgesic effect of prenatal MA exposure is supported by our previous studies (Šlamberová et al, 2011b;Yamamotová et al, 2011) as well as studies of others (Chen et al, 2010). Chen et al suggested that prenatal MA exposure could predispose an alteration in the development of nociceptive neuronal network, which leads to a long-lasting status of hypersensitivity to pain stimulations in the offspring.…”

Section: )supporting

confidence: 67%

“…Further, we found that prenatal MA exposure with respect of adult MA challenge impairs the learning abilities tested in Morris water maze (Schutová et al, 2008), affects anxiety behavior , alters pain sensitivity in Plantar tests in sex-specific manner (Yamamotová et al, 2011) and seizure susceptibility in adult male and female rats Bernášková et al, 2011). In our most recent studies we demonstrated that there is a sensitizing effect of prenatal MA exposure to the same drug in adulthood (Bubeníková-Valešová et al, 2009;Šlamberová et al, 2011a, b).…”

Section: Introductionmentioning

confidence: 60%

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Does Prenatal Methamphetamine Exposure Induce Cross-sensitization to Cocaine and Morphine in Adult Male Rats?

et al. 2012

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R e c e i ve d J a n u a r y 2 3 , 2 0 12 ; A c c e p t e d Ju n e 2 5 , 2 0 1 2 .Key words: Prenatal drug exposure -Methamphetamine -Cocaine -MorphineOpen field -Plantar test -Conditioned place preference -LocomotionNociception -Drug-seeking behavior Abstract:The aim of the present study was to examine the cross-sensitization induced by prenatal methamphetamine (MA) exposure to challenge dose of cocaine or morphine. Rat mothers received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male offspring (prenatally MA-or saline-exposed) were divided to groups with challenge doses of saline (1 ml/kg), cocaine (5 mg/kg) or morphine (5 mg/kg). Behavior in unknown environment was examined in Laboras, nociception in Plantar test, and active drug-seeking behavior in conditioned place preference (CPP). Our data demonstrate that cocaine increased the exploratory activity in Laboras test in prenatally saline-exposed, but decreased it in prenatally MA-exposed rats. An analgesic effect of cocaine was demonstrated only by the tail withdrawal and it was independent of the prenatal drug exposure. CPP test showed that prenatal MA exposure induced rather tolerance than sensitization to cocaine. In contrast to cocaine effects, morphine decreased rearing activity in both, prenatally MA-exposed and saline-exposed rats, and locomotion only in prenatally MA-exposed rats in the Laboras. In the Plantar Prague Medical Report / Vol. 113 (2012) No. 3, p. 189-205 test, the results demonstrated that morphine had an analgesic effect in prenatally saline-exposed rats but this effect was suppressed in prenatally MA-exposed rats. In the CPP test morphine induced drug-seeking behavior, which however was not affected by prenatal drug exposure. Thus, our data demonstrate that there is a cross-effect between prenatal MA exposure and the challenge dose of other drug in adulthood, however drug-seeking behavior is not increased by prenatal MA exposure as we expected.

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confidence: 67%

Section: Introductionmentioning

confidence: 60%

Does Prenatal Methamphetamine Exposure Induce Cross-sensitization to Cocaine and Morphine in Adult Male Rats?

et al. 2012

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“…The dopaminergic system, in terms of pain, has received much less attention, although stimulants like amphetamine or methamphetamine are highly effective analgesics (Yamamotová et al, 2011; Yamamotová and Šlamberová, 2012). Pain is modulated by D2 receptors, particularly within the mesolimbic dopaminergic system and the nucleus accumbens, hence in the “reward system” of the brain (Franklin, 1998; Altier and Stewart, 1999; Wood, 2006).…”

Section: Common Neurobiological Mechanisms Of Pain and Depressionmentioning

confidence: 99%

Common mechanisms of pain and depression: are antidepressants also analgesics?

Nekovarova

Yamamotová

Valeš

et al. 2014

Front. Behav. Neurosci.

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Neither pain, nor depression exist as independent phenomena per se, they are highly subjective inner states, formed by our brain and built on the bases of our experiences, cognition and emotions. Chronic pain is associated with changes in brain physiology and anatomy. It has been suggested that the neuronal activity underlying subjective perception of chronic pain may be divergent from the activity associated with acute pain. We will discuss the possible common pathophysiological mechanism of chronic pain and depression with respect to the default mode network of the brain, neuroplasticity and the effect of antidepressants on these two pathological conditions. The default mode network of the brain has an important role in the representation of introspective mental activities and therefore can be considered as a nodal point, common for both chronic pain and depression. Neuroplasticity which involves molecular, cellular and synaptic processes modifying connectivity between neurons and neuronal circuits can also be affected by pathological states such as chronic pain or depression. We suppose that pathogenesis of depression and chronic pain shares common negative neuroplastic changes in the central nervous system (CNS). The positive impact of antidepressants would result in a reduction of these pathological cellular/molecular processes and in the amelioration of symptoms, but it may also increase survival times and quality of life of patients with chronic cancer pain.

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“…Among the different dosing regimens, throughout the entire gestation is the most commonly used duration of exposure (Bubenikova-Valesova et al, 2009;Schutova et al, 2009;Yamamotova et al, 2011). This dosing regimen relates to the clinical situation where the mother is abusing MA everyday throughout pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Methamphetamine exposure during pregnancy at pharmacological doses produces neurodevelopmental and behavioural effects in rat offspring

McDonnell‐Dowling

Donlon

Kelly

2014

Intl J of Devlp Neuroscience

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In recent years methamphetamine (MA) use has become more prevalent, and of particular concern is its growing popularity of MA among women of childbearing age. However, to date, studies examining MA effects on the developing offspring in laboratory animals are limited. Thus, the aim of this study was to determine if in utero MA exposure in rats at pharmacological doses can have a negative impact on neonatal neurodevelopment and behaviour. Pregnant Sprague-Dawley dams (n=10 dams/group) received MA (0, 0.625, 1.25, 2.5mg/kg) once daily via oral gavage from gestational day 7 to 21. Maternal body weight, food and water consumption were recorded daily. A range of standard neurodevelopment parameters was examined in the offspring during the neonatal period. There were no neurodevelopmental deficits observed with offspring exposed to 0.625mg/kg MA, in fact, there were enhancements of neurodevelopment in some parameters at this low dose. However, exposure to the 1.25mg/kg MA dose resulted in significant impairments in surface righting reflex and forelimb grip in both sexes. Exposure to the 2.5mg/kg MA dose resulted in a significant reduction in ano-genital distance in males, and in both sexes resulted in delayed fur appearance and eye opening, impairments in surface righting reflex and negative geotaxis, and a reduction in body length. In conclusion, this study demonstrates that pharmacologically relevant doses of MA can have profound dose-related effects on neonatal outcome. If extrapolated to the clinical scenario this will give cause for concern regarding the risks associated with this drug of abuse at relatively low doses.

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Perinatal effect of methamphetamine on nociception in adult Wistar rats

Cited by 23 publications

References 66 publications

Does Prenatal Methamphetamine Exposure Induce Cross-sensitization to Cocaine and Morphine in Adult Male Rats?

Does Prenatal Methamphetamine Exposure Induce Cross-sensitization to Cocaine and Morphine in Adult Male Rats?

Common mechanisms of pain and depression: are antidepressants also analgesics?

Methamphetamine exposure during pregnancy at pharmacological doses produces neurodevelopmental and behavioural effects in rat offspring

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