Perinatal Development of the Lung in Rat and Spiny Mouse: Its Relation to Altricial and Precocial Timing of Birth

Oosterhuis, Wytze P.; Mooren, P.G.; Charles, R.; Lamers, W. H.

doi:10.1159/000242011

Cited by 41 publications

(31 citation statements)

References 18 publications

(32 reference statements)

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“…This chronology is very similar to the rapid increases in surfactant which occur in the 28-day fetal rabbit (-90% of gestation) (1 8), the day 14-15 fetal hamster (87-94% of gestation) (20), and the 20-day fetal rat (-90% of gestation) (21). It is of interest that the pattern of surfactant maturation in the guinea pig contrasts with the pattern described for another "precocious" species, the spiny mouse (22). Despite a relatively long gestation period (39 days) in the spiny mouse, small litter size, and neonates with fur, open eyes, and ability to thermoregulate (features similar to the guinea pig), the prenatal surfactant surge is reported to occur even later and in a more protracted fashion in the spiny mouse than in the rat or guinea pig (20,22).…”

Section: Discussionmentioning

confidence: 99%

Lung Development in the Fetal Guinea Pig: Surfactant, Morphology, and Premature Viability

Sosenko

Frank

1987

Pediatr Res

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ABSTRACT. Guinea pigs demonstrate "precocious" physical and functional development, with newborns displaying open eyes, hair, self-feeding, and temperature regulation. In addition, morphologic lung development is precocious in the guinea pig, with advanced alveolarization taking place in utero. To explore whether pulmonary surfactant development is also advanced, and at what stage prematurely delivered guinea pigs are capable of survival, we delivered fetal guinea pigs at 2-to 3-day intervals from day 49 of gestation to day 69 (birth). These were examined for chronologic changes in lung morphology, lung tissue disaturated phosphatidylcholine, phosphatidylglycerol and glycogen content, and serum glucocorticoid and thyroid hormone levels. Other prematurely delivered guinea pigs were given brief postnatal resuscitation and their survival noted. We confirmed advanced morphologic lung maturation, yet found that surfactant development, with antecedent hormone peaks and glycogen depletion, occurs during the final 10-15% of gestation. Lung biochemical development is thus "on time" in the guinea pig, rather than "precocious" compared to other frequently studied laboratory animals. In addition, >50% of fetal guinea pigs are capable of survival by 8 days prior to term, well in advance of premature survivability in other small-sized species. The gestation period of the guinea pig is considerably longer (69 days) than that of other commonly studied small-sized mammals (i.e hamster -16 days, rat -22 days, rabbit -31 days). Associated with this relatively long gestation in the guinea pig is a remarkable degree of physical and functional maturity demonstrated by the newborn of the species. At birth guinea pigs have full coats of hair, open eyes, and the ability to regulate body temperature and to feed apart from the mother (1). Engel (2) hypothesized in 1953 that the lung growth and development of a species should parallel the overall development present at birth. In support of Engel's hypothesis, Lechner and Banchero (3) Received Oct. 2, 1986; accepted Dec. 4, 1986 found advanced morphologic lung development in the newborn guinea pig.We questioned whether other aspects of lung development, in addition to lung morphology, would also be accelerated in the developing guinea pig, adding further support to Engel's hypothesis. The present study was undertaken to investigate the following: I ) the developmental pattern of the surfactant system in the fetal guinea pig, 2) how surfactant development is chronologically related to morphologic development in the guinea pig lung, 3) whether an endogenous rise or peak in serum glucocorticoid and/or thyroid hormone levels precedes the maturational changes in lung morphology and/or surfactant. Finally, we sought to determine the viability of premature guinea pigs delivered at varying gestational ages, and what degree of lung morphologic and surfactant development would be associated with premature survival. METHODSTimed-pregnancy Camm-Hartley guinea pigs were obtained from Camm Laboratories, ...

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Section: Discussionmentioning

confidence: 99%

Lung Development in the Fetal Guinea Pig: Surfactant, Morphology, and Premature Viability

Sosenko

Frank

1987

Pediatr Res

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“…The animals were fed pelleted rat chow (Hope Farms diet RMH-B). Fetal age was read from a chan relating body weight to gestational age [36]. Hormones were administered daily (predniso lone, 50 pg-g-1 body weight; triiodothyronine, 0.8 pg-g~1 body weight) or twice daily (glucagon, 25 p g -g '1 body weight) by intraperitoneal injection.…”

Section: Animalsmentioning

confidence: 99%

Perinatal Development of the Small Intestine and Pancreas in Rat and Spiny Mouse

1985

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Rat (Raitus norvegicus)and spiny mouse (Acomys cahirinus)are closely related species that mainly differ in the developmental timing of birth. A comparison between the developmental profiles of some characteristic enzymes of the small intestine (lactase and sucrase) and of the pancreas (amylase) of both species was carried out to elucidate the question to what extent these enzymic profiles and hence the maturation of these organs was related to the process of birth. It was found that these organ-specific enzymes become first detectable at the same developmental stage in both species. Likewise, the weaning phase of the enzymic profiles occurred at the same developmental time point in both species. It is argued that both the first appearance and the weaning increase in enzyme activity follow an inherent biological program that can only be modulated by hormones. In contrast, the perinatal phase of the enzymic profile is completely dependent on the developmental timing of birth, and therefore appears not to be anchored to a particular developmental time point but rather to be dependent on birth-associated (hormonal) adaptation. In accordance with this hypothesis it was found that the development of the microscopic anatomy of the small intestine proceeded independently of the functional adaptation of the intestine to the process of birth.

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“…As a model of viral illness appropriate to second-trimester pregnancy in women, we have used the spiny mouse (Acomys cahirinus) , an animal whose brain development is more advanced by the time of birth [26]. Indeed, the spiny mouse may be said to be precocial in that organogenesis is largely complete by the time of birth, and the neonates are capable of motor activity and thermoregulation [27,28,29,30,31]. In addition, the spiny mouse secretes cortisol as the major circulating glucocorticoid (cf.…”

Section: Introductionmentioning

confidence: 99%

Prenatal Exposure to the Viral Mimetic Poly I:C Alters Fetal Brain Cytokine Expression and Postnatal Behaviour

et al. 2014

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An increased incidence of mental illness disorders is found in children and adolescents born to mothers who experienced an infection-based illness during pregnancy. Animal models to study the prenatal origin of such outcomes of pregnancy have largely used conventional rodents, which are immature (altricial) at birth compared with the human neonate. In this study, we used the precocial spiny mouse (Acomys cahirinus), whose offspring have completed organogenesis at birth, and administered a single subcutaneous injection of a 5 mg/kg dose of the viral mimetic poly I:C (polyriboinosinic-polyribocytidylic acid) at mid gestation (20 days; term is 39 days). Prenatal exposure to poly I:C caused a transient weight loss in the pregnant dam, produced a downregulation of the proinflammatory cytokine tumour necrosis factor-α in the fetal brain, and resulted in abnormalities in sensorimotor gating and reduced social interaction, memory and learning in juvenile offspring. No changes in exploratory activity or anxiety and fear behaviours were found between the treatment groups. This study provides evidence that, in a rodent model that more closely resembles human brain development, prenatal infection can lead to behavioural abnormalities in postnatal life.

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Perinatal Development of the Lung in Rat and Spiny Mouse: Its Relation to Altricial and Precocial Timing of Birth

Cited by 41 publications

References 18 publications

Lung Development in the Fetal Guinea Pig: Surfactant, Morphology, and Premature Viability

Lung Development in the Fetal Guinea Pig: Surfactant, Morphology, and Premature Viability

Perinatal Development of the Small Intestine and Pancreas in Rat and Spiny Mouse

Prenatal Exposure to the Viral Mimetic Poly I:C Alters Fetal Brain Cytokine Expression and Postnatal Behaviour

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