Perinatal Complications in the History of Asthmatic Children

Salk, Lee; Grellong, Bruce; Straus, Wendy; Dietrich, Jeanne

doi:10.1001/archpedi.1974.02110200032004

Cited by 14 publications

(9 citation statements)

References 7 publications

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“…The perinatal period and early infancy may be a particularly vulnerable period in this re spect. Thus, pharmacotherapy of pregnant women [19] and various perinatal stress factors like preec lampsia, blood group incompatibility and respiratory distress [20] have been suggested to be associated with an increased risk for development of allergic disease.…”

Section: Discussionmentioning

confidence: 99%

Intrauterine Exposure to the Beta-Adrenergic Receptor-Blocking Agent Metoprolol and Allergy

Björkstén

Finnström²,

Wichman³

1988

Int Arch Allergy Immunol

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Cord blood IgE levels and the development of allergy were studied in 29 children born by mothers who had been treated with the β-adrenergic receptor blocking agent, metoprolol, during the pregnancy and in 23 children of placebo-treated mothers. In 13 (45%) of the former and 3 (15%) of the placebo group elevated cord blood IgE levels, i.e. more than 0.9 kU/l and/or obvious or probable allergy developed (p = 0.03). The findings support previous experimental observations that β-blocking agents may enhance IgE antibody formation. It also adds to the number of environmental factors that may increase the risk for atopic disease in children.

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Section: Discussionmentioning

confidence: 99%

Intrauterine Exposure to the Beta-Adrenergic Receptor-Blocking Agent Metoprolol and Allergy

Björkstén

Finnström²,

Wichman³

1988

Int Arch Allergy Immunol

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“…17 Retrospective studies found that increased stress on infants was associated with asthma onset in the first years of life. 18,19 One prospective study that assessed stressful family life events found no evidence that stress contributed to asthma onset by age 6. 20 Questionnaire measures of family life events seem to capture different elements of family life than the stress that is developmentally salient for infants in their first year of life.…”

mentioning

confidence: 99%

Onset and Persistence of Childhood Asthma: Predictors From Infancy

et al. 2001

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ABSTRACT.Objective. In a prospective study of children with a family history of asthma, asthma onset by 3 years of age was found previously to be positively associated with variables from the first year of life, including elevated total immunoglobulin E (IgE), frequent respiratory infections, and parenting difficulties. We followed this cohort of genetically at-risk children to investigate the relationship between factors assessed in infancy and asthma, allergy, and psychological status at school age.Methods. A cohort of 150 children who were at risk for developing asthma were identified prenatally on the basis of the mothers' having asthma. For 28 children, the father had asthma as well, putting them at bilateral genetic risk. Families primarily were middle and upper middle class Caucasians. Parents came to the clinic during the third trimester of pregnancy for assessments of medical and psychosocial functioning. A home visit took place when the infant was 3 weeks old, when parenting risk was assessed before the onset of any asthma symptoms. Parenting difficulties included problems with infant caregiving as well as components of maternal functioning, such as postpartum depression and inadequate marital support. Blood was drawn for serum IgE at 6 months of age. Parents and offspring subsequently came to the clinic multiple times, with the last clinic visit during the child's sixth year. Follow-up at age 6 involved a clinic visit for allergy and psychosocial evaluations, consisting of interviews and a behavior questionnaire. Seventy-seven children received the allergy and psychosocial evaluation, 26 received the psychosocial evaluation in the clinic, and 30 families received telephone interviews and mailed in questionnaires. Additional monitoring of families by telephone and mail was maintained over the next 2 years, until the children were 8, to ensure accurate characterization of the course of illness. Comprehensive medical records were obtained and reviewed for all health care contacts. Children were designated as having asthma when there was documentation in medical records of physician-diagnosed asthma, observed wheezing, and/or prescription of asthma medications during the time period when the child was between 6 and 8 years of age. Parental reports of the occurrence of asthma corroborated the medical record data.Results. Data regarding asthma status were available for 145 children through 8 years of age. Forty (28%) of the children manifested asthma between 6 and 8 years of age. Among variables previously reported to predict asthma onset by age 3, 3 proved to have significant univariate relationships with asthma between ages 6 and 8: elevated IgE levels measured when the children were 6 months of age, global ratings of parenting difficulties measured when infants were 3 weeks old, and higher numbers of respiratory infections in the first year of life. Among these offspring of mothers with asthma, paternal asthma showed a significant association with asthma between ages 6 and 8. Eczema in the first year was...

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“…Some observations indicate that the use of opiates in labour and instrumental delivery both possibly increase the risk for atopic eczema in infancy [28]. There are also two reports suggesting that perinatal stress may be associated with development of asthma and allergic disease later during cbildbood [29,30]. In one study [29], a variety of perinatal stress factors were suggested to play a role, including prematurity, complicated delivery and neonatal anaesthesia and surgery.…”

Section: Perinatal Stressmentioning

confidence: 99%

“…There are also two reports suggesting that perinatal stress may be associated with development of asthma and allergic disease later during cbildbood [29,30]. In one study [29], a variety of perinatal stress factors were suggested to play a role, including prematurity, complicated delivery and neonatal anaesthesia and surgery. In the other study [30] general anaesthesia in infants was associated with subsequent development of respiratory tract allergy.…”

Section: Perinatal Stressmentioning

confidence: 99%