Perinatal co-exposure to methylmercury and PCB153 or PCB126 in rats alters the cerebral cholinergic muscarinic receptors at weaning and puberty

Coccini, Teresa; Roda, Elisa; Castoldi, Anna Federica; Goldoni, Matteo; Poli, Diana; Bernocchi, Graziella; Manzo, Luigi

doi:10.1016/j.tox.2007.05.018

Cited by 40 publications

(34 citation statements)

References 57 publications

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“…Moreover, the differences in the dose magnitude, route of exposure, the dosing regime and the experimental endpoints make comparisons difficult. Dietary exposure via drinking water during gestation and lactation at doses of 0.5 mg/kg/ day was used in some studies, including those performed under the DEVNERTOX project [45,46]. Any significant effects on the maternal health status, reproduction success, offspring's body weight at birth and body weight increase from birth to weaning were not reported.…”

Section: Effects Of the Mehg Exposurementioning

confidence: 99%

“…Similar exposure regime as that in the present study was also employed in other studies performed under the DEVNERTOX project. In one of these studies [45] PCB 153 was administered in diet at daily doses of 5.0 mg/ kg, and in the second one [46] at 1.0 mg/kg. None of these studies revealed adverse effects of PCB 153 on maternal health and reproduction.…”

Section: Effects Of Combined Exposure To Mehg and Pcb 153mentioning

confidence: 99%

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Early developmental effects of separate or combined perinatal exposure to methylmercury (MeHg) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) in the rat

Sitarek¹,

Gralewicz²

2009

International Journal of Occupational Medicine and Environmental Health

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Objectives: Methylmercury (MeHg) and polychlorinated biphenyls (PCBs) are ubiquitous and persistent environmental pollutants and food contaminants. Both are neurotoxic, especially for the developing nervous system. Material and Methods: Female rats were exposed from day 7 of pregnancy up to day 21 after the delivery to MeHg in drinking water, PCB 153 per os or MeHg+PCB 153. Assessment of the exposure effects in mothers included food and water intake, body weight and reproduction success. Assessment of the progeny comprised determination of body weight, time of pinna detachment, eye opening, incisor eruption, and the negative geotaxis, grip strength and righting reflex. Results: The following effects of the exposures were observed: A) MeHg: 0.5 mg/kg/day -no effect on maternal health status and reproduction. In the progeny: faster incisor eruption and hastened negative geotaxis development. MeHg 2.0 mg/kg/day: In mothers: signs of MeHg toxicity (reduced food intake and body weight, ataxia) during lactation. In the progeny: reduced rate of body weight increase, accelerated incisor eruption but delayed development of the righting reflex. B) PCB 153 exposure: 1.0 mg/kg/day: no effect on maternal health status, reproduction success or morphological and physical development of the progeny; 5.0 mg/kg/day: no effect on maternal health status and reproduction. In the progeny: accelerated growth in females, faster pinna detachment and incisor eruption but delayed development of the grip strength. C) MeHg+PCB153 exposure: none overt effect was noted in mothers or in their progeny. Conclusion: The results confirm the ability of a low level perinatal exposure to MeHg or PCB 153 to affect the early development in the rat. They have not provided, however, an evidence of a synergistic interaction of these contaminants. To the contrary, the results suggest that, at least under the conditions prevailing in the present study, MeHg and PCB 153 interact antagonistically.

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Section: Effects Of the Mehg Exposurementioning

confidence: 99%

Section: Effects Of Combined Exposure To Mehg and Pcb 153mentioning

confidence: 99%

Early developmental effects of separate or combined perinatal exposure to methylmercury (MeHg) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) in the rat

Sitarek¹,

Gralewicz²

2009

International Journal of Occupational Medicine and Environmental Health

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“…per day was ineffective (Coccini et al, 2006). This contradictory findings were attributed to the longer exposure period in the study by Coccini et al (2007b), which covers a longer period of the postnatal stage. Comparable results in lymphocyte MRs were obtained by Coccini et al (2007a), which observed an enhanced MR density after exposure of rats from GD 7 to PND 7.…”

Section: Number Of Stillbirthsmentioning

confidence: 69%

“…The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors. Coccini et al (2007b), an increase in rat brain MR density has been observed in pups with perinatal exposure from GD7 to PND7 to 1 mg/kg b.w. per day MeHg, whereas a dose of 0.5 mg/kg b.w.…”

Section: Number Of Stillbirthsmentioning

confidence: 93%

Collate the literature on toxicity data on mercury in experimental animals and humans (Part I – Data on organic mercury)

Hassauer

Kaiser

Schneider

et al. 2012

EFSA Supporting Publications

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It was the scope of this project to collate, compile and summarise the scientific literature on the toxicity of methyl mercury, inorganic mercury and total mercury in humans and experimental animals published since 2002 and not evaluated in former JECFA risk assessments. Epidemiological data on MeHg toxicity confirmed former findings on an association between prenatal exposure and developmental neurotoxicity. Recent findings also support an influence of methyl mercury on the cardiovascular and immune system. Existing epidemiological data reveal several shortcomings limiting their suitability for risk assessment. Developmental neurotoxicity seems to be the most critical effect of MeHg in animals. A LOAEL of 0.01 mg/kg b.w. per day has been reported in young mice for locomotor activity exposed in utero. Rats seem to be less sensitive towards this endpoint: a NOAEL of 0.04 mg/kg b.w. per day has been reported in this species for locomotor activity. Systemic effects other than neurotoxicity have been mostly observed at higher doses than those producing neurotoxicity. No qualified epidemiological data appropriate for the evaluation of the toxicity of inorganic mercury after oral intake have been identified due to several limitations of the studies, e.g. small study group, insufficient control for confounders, inadequate exposure assessment. Toxicological studies in experimental animals widely confirmed former findings with respect to the target organs (neuro-, liver-, kidney-, immune-and reproductive toxicity, oxidative stress). The animal studies indicate that there might be relevant toxicological effects (developmental toxicity, liver toxicity) of inorganic mercury at dose levels similar or below the BMDL 10 value used for the derivation of the existing PTWI. However, due to some limitations of the studies no final conclusions can be drawn from these studies and the findings need further confirmation.

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“…A idade, o gênero, a saúde como um todo, a forma química do Hg, o tipo de fonte do agente tóxico -por exemplo, para o MeHg, a espécie de peixe -a localização geográfica, a estação do ano, as características genéticas e o tipo de nutrientes presentes na dieta da população são algumas das co-variáveis que podem influenciar na toxicocinética e toxicodinâmica do Hg (BÉLANGER et al, 2008a(BÉLANGER et al, , 2008bBEMIS;SEEGAL, 2000;CASTOLDI et al, 2008;MAGOS, 2006;COCCINI et al, 2006COCCINI et al, , 2007GRANDJEAN et al, 1998;GROTTO et al, 2011a;PASSOS et al, 2003;VAHTER et al, 2007).…”

Section: Fatores Nutricionais Podem Afetar Os Efeitos Tóxicos Do Mercunclassified

Efeito da sazonalidade na exposição ao mercúrio e nos marcadores do estresse oxidativo e de inflamação em populações ribeirinhas da Amazônia

Valentini¹

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Perinatal co-exposure to methylmercury and PCB153 or PCB126 in rats alters the cerebral cholinergic muscarinic receptors at weaning and puberty

Cited by 40 publications

References 57 publications

Early developmental effects of separate or combined perinatal exposure to methylmercury (MeHg) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) in the rat

Early developmental effects of separate or combined perinatal exposure to methylmercury (MeHg) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) in the rat

Collate the literature on toxicity data on mercury in experimental animals and humans (Part I – Data on organic mercury)

Efeito da sazonalidade na exposição ao mercúrio e nos marcadores do estresse oxidativo e de inflamação em populações ribeirinhas da Amazônia

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