Perinatal characteristics and bone cancer risk in offspring – a Scandinavian population-based study

Troisi, Rebecca; Stephansson, Olof; Jacobsen, Jacob; Tretli, Steinar; Sørensen, Henrik Toft; Gissler, Mika; Kaaja, Risto; Ekbom, Anders; Hoover, Robert N.; Grotmol, Tom

doi:10.3109/0284186x.2013.862594

Cited by 7 publications

(4 citation statements)

References 21 publications

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“…Finally, seven case-control studies [ 14 , 20 , 21 , 24 , 34 , 35 , 36 ] were included according to our criteria. Among the seven studies, three [ 21 , 35 , 36 ] reported more than one kind of bone tumor, thus these studies were regarded as separate reports according to the type of cancer. In addition, one study [ 35 ] applied two independent datasets from two different countries and reported results separately.…”

Section: Resultsmentioning

confidence: 99%

“…As for the dose-response analysis, a total of eight independent reports, including Schuz et al [ 18 ] (2007), Gelberg et al [ 20 ] (1997), Buckley et al [ 21 ] (1998) a, Buckley et al [ 21 ] (1998) b, Troisi et al [ 24 ] (2006), Troisi et al [ 36 ] (2014) a, Troisi et al [ 36 ] (2014) b and Troisi et al [ 36 ] (2014) c, providing adequate data satisfied the criteria. The results were shown in Figure 3 .…”

Section: Resultsmentioning

confidence: 99%

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High Birth Weight Increases the Risk for Bone Tumor: A Systematic Review and Meta-Analysis

Chen

Yang

et al. 2015

IJERPH

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There have been several epidemiologic studies on the relationship between high birth weight and the risk for bone tumor in the past decades. However, due to the rarity of bone tumors, the sample size of individual studies was generally too small for reliable conclusions. Therefore, we have performed a meta-analysis to pool all published data on electronic databases with the purpose to clarify the potential relationship. According to the inclusion and exclusion criteria, 18 independent studies with more than 2796 cases were included. As a result, high birth weight was found to increase the risk for bone tumor with an Odds Ratio (OR) of 1.13, with the 95% confidence interval (95% CI) ranging from 1.01 to 1.27. The OR of bone tumor for an increase of 500 gram of birth weight was 1.01 (95% CI 1.00–1.02; p = 0.048 for linear trend). Interestingly, individuals with high birth weight had a greater risk for osteosarcoma (OR = 1.22, 95% CI 1.06–1.40, p = 0.006) than those with normal birth weight. In addition, in the subgroup analysis by geographical region, elevated risk was detected among Europeans (OR = 1.14, 95% CI 1.00–1.29, p = 0.049). The present meta-analysis supported a positive association between high birth weight and bone tumor risk.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

High Birth Weight Increases the Risk for Bone Tumor: A Systematic Review and Meta-Analysis

Chen

Yang

et al. 2015

IJERPH

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“…Bone cancer imposes the risk of permanent restrictions in mobility, reduced function or even the loss of a limb, and possible physical disfigurement [4]. Reported or proposed risk factors for bone cancer include age, male sex, education, occupation, marital status, and area of residence [4] [5]. There is marked geographic variation observed in the prevalence of Paget's disease, with a high prevalence noted in the UK, Australia, and North America and a lower prevalence observed in Asia and the Middle East [6] [7].…”

Section: Introductionmentioning

confidence: 99%

Bone Cancer Mortality in Inner Mongolia from 2008 to 2012

Guo¹,

Hao²,

Du³

et al. 2015

OJEpi

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Objective: The aim of our study was to assess bone cancer mortality and the related social factors in Inner Mongolia in China. Methods: We obtained data from the Centers for Disease Control in Inner Mongolia from five monitoring points of the Death Registry System in Inner Mongolia from 2008 to 2012. We calculated the crude mortality rate for bone cancer. The χ 2 test was used to examine differences in bone cancer mortality rates between sexes and years. Unconditional logistic regressions were applied to analyze the effect of socio-demographic characteristics by sex. Results: Between 2008 and 2012, the crude mortality rate of bone cancer was 1.12/100000 (95% confidence interval = 1.02 -1.21). The bone cancer mortality was 2.24 in men and 1.25 in women, resulting in a male-female ratio of 1.8. No between-year difference in the mortality rate was observed between 2008 and 2012 (men: χ 2 = 4.65, P = 0.325; women: χ 2 = 2.21, P = 0.698). In general, mortality increased with increasing age. People with a lower education level exhibited an increased risk of bone cancer among both men and women. Jobs involving extensive manual labor decreased the likelihood of bone cancer mortality, and the odds ratio was higher for men than women (0.6 vs. 0.45). Unmarried people had a higher risk for bone cancer than married people. Conclusion: The mortality rate of bone cancer was not significantly different between men and women from 2008 to 2012. The risk of bone cancer increased with age among both sexes. Unmarried people and those with a low education status had an elevated risk of bone cancer, whereas employment in a field involving extensive manual labor appeared to be a protective factor against bone cancer.

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“…Before such cohort studies data are available, possible initial strategies would be to evaluate paternal health parameters (i.e. Se status and fertility parameters) during preconception and associate them with perinatal factors postulated to affect breast cancer risk such as birth weight and length [47] and umbilical cord hormone [48] and mammary stem cell levels [49]. Furthermore, measuring breast density in girls during pubertal development and in young women using radiation-free technologies [50] promoted changes in DNA methylation and miRNA expression in male sperm and female offspring mammary gland that were associated with increased later breast cancer risk 7,8 .…”

Section: Discussionmentioning

confidence: 99%

Paternal nutrition and cancer programming: the influence of selenium deficiency or supplementation on the susceptibility of female offspring to chemically-induced mammary carcinogenesis

Guido¹

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Perinatal characteristics and bone cancer risk in offspring – a Scandinavian population-based study

Cited by 7 publications

References 21 publications

High Birth Weight Increases the Risk for Bone Tumor: A Systematic Review and Meta-Analysis

High Birth Weight Increases the Risk for Bone Tumor: A Systematic Review and Meta-Analysis

Bone Cancer Mortality in Inner Mongolia from 2008 to 2012

Paternal nutrition and cancer programming: the influence of selenium deficiency or supplementation on the susceptibility of female offspring to chemically-induced mammary carcinogenesis

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