Perinatal blastomycosis

Maxson, Suzanne; Sf, Miller; Af, Tryka; Ge, Schutze

doi:10.1097/00006454-199209000-00016

Cited by 41 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[32][33][34] The wide variety of clinical presentations of blastomycosis is a major factor contributing to the difficulty providers have in considering the diagnosis. Although rare, reports have been published regarding direct inoculation leading to cutaneous blastomycosis 35 as well as transmission via sexual contact 36 and intrauterine transmission, 37 the vast majority of infections occur via the inhalational route. As a result, a large number of patients with symptomatic disease will have evidence of pulmonary involvement.…”

Section: Pathogenesis and Clinical Diseasementioning

confidence: 99%

Pulmonary Blastomycosis

Bariola

Vyas

2011

Semin Respir Crit Care Med

View full text Add to dashboard Cite

Blastomyces dermatitidis is acquired in almost all cases via inhalation, and pulmonary disease is the most frequent clinical manifestation of blastomycosis. Pulmonary disease can range from asymptomatic infection to rapidly severe and fatal disease. Most cases will present as pneumonia, either acute or chronic, or as a lung mass. In rare cases pulmonary blastomycosis is associated with the acute respiratory distress syndrome. Blastomycosis can present as isolated pulmonary disease or along with coexisting extrapulmonary disease that usually will involve the skin, bony structures, genitourinary tract, or central nervous system. Diagnosis is largely based on isolation of the organism via culture or visualization of the organism in clinical specimens. Detection of urinary Blastomyces antigen is a recent addition to diagnostic options. Itraconazole is the drug of choice for most forms of the disease; amphotericin B is reserved for the more severe forms. Newer azoles such as voriconazole and posaconazole have a limited role in the treatment of pulmonary blastomycosis.

show abstract

Section: Pathogenesis and Clinical Diseasementioning

confidence: 99%

Pulmonary Blastomycosis

Bariola

Vyas

2011

Semin Respir Crit Care Med

View full text Add to dashboard Cite

show abstract

“…The route of acquisition is not well established, and there are few reported cases. In a review of perinatal blastomycosis, transmission to the newborn infant was proposed to be through aspiration of colonized vaginal secretions as suggested by primarily pulmonary involvement in affected newborns and through hematogenous spread as evidenced by placental involvement [2, 9, 10]. There are no previous reports examining the use of Blastomyces urine antigen for diagnosis of newborn infants born to mothers with blastomycosis during pregnancy.…”

Section: Commentmentioning

confidence: 99%

Blastomyces Antigen Detection for Monitoring Progression of Blastomycosis in a Pregnant Adolescent

Tarr

Marcinak

Mongkolrattanothai

et al. 2007

Infectious Diseases in Obstetrics and Gynecology

View full text Add to dashboard Cite

Although disseminated blastomycosis is a rare complication in pregnancy, delay in diagnosis and treatment can be fatal. We investigate the use of the Blastomyces urine antigen in diagnosis following disease progression in the intrapartum, postpartum, and neonatal periods. We describe a case of disseminated blastomycosis in a pregnant adolescent and review the pertinent literature regarding treatment and monitoring blastomycosis in pregnancy and the neonatal periods. This is the first reported case in which the Blastomyces urine antigen is utilized as a method of following disease activity during pregnancy confirming absence of clinically evident disease in a neonate. Urine antigen detection for blastomycosis can be useful for following progression of disease in patients with disseminated blastomycosis in both the intrapartum and postpartum periods.

show abstract

“…The youngest infants with blastomycosis were 18 days and 3 weeks of age, both of whom died. 13,14 In the first infant, the mother had skin and bone disease during pregnancy, which was diagnosed as blastomycosis after the infant's autopsy results showed pulmonary and renal blastomycosis. The authors suspected aspiration of colonized vaginal secretions or ascending vaginal infection, rather than hematogenous transplacental spread.…”

Section: Discussionmentioning

confidence: 99%