Perinatal bisphenol A (BPA) exposure alters brain oxytocin receptor (OTR) expression in a sex- and region- specific manner: A CLARITY-BPA consortium follow-up study

Witchey, Shannah K.; Fuchs, Joelle; Patisaul, Heather B.

doi:10.1016/j.neuro.2019.06.007

Cited by 31 publications

(19 citation statements)

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“…Using brain tissues from stop-dose male and female pups described in Rebuli et al (2015) (i.e., the residual brain tissues from these pups after the analysis in Arambula et al ( 2017)), Witchey et al (2019) carried out additional assessments of Oxtr binding across several brain regions.…”

Section: Methodsmentioning

confidence: 99%

“…All data from the core study and the majority of data from the grantee studies, including unpublished studies, are available in the NTP Chemical Effects in Biological Systems (CEBS) database: https://cebs.niehs.nih.gov/cebs/program/CLARITY-BPA . The data for the remaining two studies of brain and behavior that evaluated tissues from the CLARITY-BPA program, but were not funded by the program, are available upon request from Dr. Heather Patisaul (Arambula et al 2018;Witchey et al 2019).…”

Section: Executive Summarymentioning

confidence: 99%

“…Findings of the Consortium Linking Academic and Regulatory Insights on Bisphenol A Toxicity (CLARITY-BPA) core study (NTP 2018) and the investigational studies by the laboratories of Heather Patisaul (Arambula et al 2016;Arambula et al 2017;Arambula et al 2018;Rebuli et al 2015;Witchey et al 2019) and Cheryl Rosenfeld (Cheong et al 2018;Johnson et al 2016) with respect to the potential effects of bisphenol A (BPA) on the brain and behavior are summarized below. All individual animal data for these studies are available online (https://cebs.niehs.nih.gov/cebs/program/CLARITY-BPA) with exception of two studies.…”

Section: Chapter 1 Brain and Behaviormentioning

confidence: 99%

“…All individual animal data for these studies are available online (https://cebs.niehs.nih.gov/cebs/program/CLARITY-BPA) with exception of two studies. The data for the remaining two studies of brain and behavior that evaluated tissues from the CLARITY-BPA program, but were not funded by the program, are available upon request from Dr. Heather Patisaul (Arambula et al 2018;Witchey et al 2019). The study details, including endpoints measured and timing of assessment, are detailed in Table 2.…”

Section: Chapter 1 Brain and Behaviormentioning

confidence: 99%

See 3 more Smart Citations

NTP Research Report on the Consortium Linking Academic and Regulatory Insights on Bisphenol A Toxicity (CLARITY-BPA): A Compendium of Published Findings

2021

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Section: Methodsmentioning

confidence: 99%

Section: Executive Summarymentioning

confidence: 99%

Section: Chapter 1 Brain and Behaviormentioning

confidence: 99%

Section: Chapter 1 Brain and Behaviormentioning

confidence: 99%

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NTP Research Report on the Consortium Linking Academic and Regulatory Insights on Bisphenol A Toxicity (CLARITY-BPA): A Compendium of Published Findings

2021

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“…Maternal and prenatal exposure to bisphenols in humans is associated with pregnancy duration and birth weight [ 16–19 ], increased risk of preeclampsia [ 20 ], early childhood behavior [ 21–23 ], childhood body mass index (BMI) [ 24 ], and peripubertal metabolic homeostasis [ 25 , 26 ]. Studies in mice have demonstrated that prenatal or early-life exposure to bisphenols is associated with altered brain development and behavior [ 27 ] as well as disruptions in metabolic homeostasis [ 28–31 ], glucose metabolism [ 32 , 33 ], neuroendocrine function [ 34 , 35 ], and immune function [ 36 , 37 ]. Despite these developments in understanding of the association between prenatal bisphenol exposure and phenotypic outcomes in offspring, less is known of the possible mechanism through which bisphenols elicit these outcomes.…”

Section: Introductionmentioning

confidence: 99%

Maternal environmental exposure to bisphenols and epigenome-wide DNA methylation in infant cord blood

McCabe

Padmanabhan

Jones

et al. 2020

Environmental Epigenetics

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Maternal prenatal exposures, including bisphenol A (BPA), are associated with offspring’s risk of disease later in life. Alterations in DNA methylation may be a mechanism through which altered prenatal conditions (e.g. maternal exposure to environmental toxicants) elicit this disease risk. In the Michigan Mother and Infant Pairs Cohort, maternal first-trimester urinary BPA, bisphenol F, and bisphenol S concentrations were tested for association with DNA methylation patterns in infant umbilical cord blood leukocytes (N = 69). We used the Illumina Infinium MethylationEPIC BeadChip to quantitatively evaluate DNA methylation across the epigenome; 822 020 probes passed pre-processing and quality checks. Single-site DNA methylation and bisphenol models were adjusted for infant sex, estimated cell-type proportions (determined using cell-type estimation algorithm), and batch as covariates. Thirty-eight CpG sites [false discovery rate (FDR) <0.05] were significantly associated with maternal BPA exposure. Increasing BPA concentrations were associated with lower DNA methylation at 87% of significant sites. BPA exposure associated DNA methylation sites were enriched for 38 pathways significant at FDR <0.05. The pathway or gene-set with the greatest odds of enrichment for differential methylation (FDR <0.05) was type I interferon receptor binding. This study provides a novel understanding of fetal response to maternal bisphenol exposure through epigenetic change.

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Evaluating endocrine disrupting chemicals: A perspective on the novel assessments in CLARITY‐BPA

Howdeshell,

Beverly,

Blain

et al. 2023

Birth Defects Research

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BackgroundThe Consortium Linking Academic and Regulatory Insights on Bisphenol A Toxicity (CLARITY‐BPA) was a collaborative research effort to better link academic research with governmental guideline studies. This review explores the secondary goal of CLARITY‐BPA: to identify endpoints or technologies from CLARITY‐BPA and prior/concurrent literature from these laboratories that may enhance the capacity of rodent toxicity studies to detect endocrine disrupting chemicals (EDCs).MethodsA systematic literature search was conducted with search terms for BPA and the CLARITY‐BPA participants. Relevant studies employed a laboratory rodent model and reported results on 1 of the 10 organs/organ systems evaluated in CLARITY‐BPA (brain and behavior, cardiac, immune, mammary gland, ovary, penile function, prostate gland and urethra, testis and epididymis, thyroid hormone and metabolism, and uterus). Study design and findings were summarized, and a risk‐of‐bias assessment was conducted.ResultsSeveral endpoints and methods were identified as potentially helpful to detect effects of EDCs. For example, molecular and quantitative morphological approaches were sensitive in detecting alterations in early postnatal development of the brain, ovary, and mammary glands. Hormone challenge studies mimicking human aging reported increased susceptibility of the prostate to disease following developmental BPA exposure. Statistical analyses for nonmonotonic dose responses, and computational approaches assessing multiple treatment‐related outcomes concurrently in linked hormone‐sensitive organ systems, reported effects at low BPA doses.ConclusionsThis review provided an opportunity to evaluate the unique insights provided by nontraditional assessments in CLARITY‐BPA to identify technologies and endpoints to enhance detection of EDCs in future studies.

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Perinatal bisphenol A (BPA) exposure alters brain oxytocin receptor (OTR) expression in a sex- and region- specific manner: A CLARITY-BPA consortium follow-up study

Cited by 31 publications

References 123 publications

NTP Research Report on the Consortium Linking Academic and Regulatory Insights on Bisphenol A Toxicity (CLARITY-BPA): A Compendium of Published Findings

NTP Research Report on the Consortium Linking Academic and Regulatory Insights on Bisphenol A Toxicity (CLARITY-BPA): A Compendium of Published Findings

Maternal environmental exposure to bisphenols and epigenome-wide DNA methylation in infant cord blood

Evaluating endocrine disrupting chemicals: A perspective on the novel assessments in CLARITY‐BPA

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