Perinatal Aspects of Omphalocele and Gastroschisis

Colombani, Paul M.; Cunningham, M. Douglas

doi:10.1001/archpedi.1977.02120250068011

Cited by 29 publications

(21 citation statements)

References 7 publications

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“…The association between young maternal age and gastroschisis was first reported in the late 1970s, and this risk factor has been documented consistently in subsequent studies (4)(5)(6). However, the increased prevalence of gastroschisis is not because of an increase in teen births, which have declined in recent years, or to a change in the distribution of births to teen mothers, as birth rates have decreased among women of all ages <20 years (7).…”

Section: Discussionmentioning

confidence: 99%

Increasing Prevalence of Gastroschisis — 14 States, 1995–2012

Jones¹,

Isenburg²,

Salemi³

et al. 2016

MMWR Morb. Mortal. Wkly. Rep.

162

142

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with all other racial/ethnic groups included in the total). The gastroschisis case definition was based on the British Pediatric Association Classification of Diseases code (756.71) or the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code for gastroschisis (756.73, or before 10/1/2009, 756.79, with verification to confirm cases of gastroschisis, because the previous code was shared with omphalocele). Gastroschisis cases included live births, fetal deaths, † and elective terminations. § Data were pooled at CDC, and gastroschisis prevalence was calculated for each year, maternal age group, and race/ethnicity. Prevalence was calculated as number of gastroschisis cases among all birth outcomes divided by the total number of live births. The denominators of total number of live births in the same catchment area as the birth defects surveillance program were reported by states or obtained from public use data files. Poisson exact methods were used to calculate 95% CIs for each prevalence estimate. Prevalence ratios were calculated by dividing the prevalence during 2006-2012 by the prevalence during 1995-2005, and CIs for the prevalence ratios were calculated using Poisson regression.Because the comparison of prevalence between the two study periods involved an artificial breakpoint during the 18-year data span and only examined pooled prevalence within those periods, joinpoint regression analysis was used to identify statistically significant changes in the annual prevalence of gastroschisis over the course of the entire study period (1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012). Joinpoint regression initially models annual trend data by fitting a straight line (i.e., zero joinpoints). Then, joinpoints are added, one at a time, and a Monte Carlo permutation test is used to determine the optimal number of joinpoints. Each joinpoint in the final model corresponds to a significant change in the trend, and an AAPC and its 95% CI are calculated to describe how the rate changes within each time interval (3). The estimated overall percent change was calculated by first converting the AAPC to the projected single year change in prevalence and then exponentiating to the number of years studied minus one to estimate the total increase throughout the 18 years. This gives the magnitude of the increase, which

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Section: Discussionmentioning

confidence: 99%

Increasing Prevalence of Gastroschisis — 14 States, 1995–2012

Jones¹,

Isenburg²,

Salemi³

et al. 2016

MMWR Morb. Mortal. Wkly. Rep.

162

142

View full text Add to dashboard Cite

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“…They reported a single case of DS with omphalocele and reviewed some of the available evidence suggesting an association: an epidemiological study of midline defects in which the presence of omphalocele was evaluated in trisomies 13, 18, and 21 [Khoury et al, 1988] and seven case series of omphalocele [Osuna and Lindham, 1976;Colombani and Cunningham, 1977;Knight et al, 1981;Hauge et al, 1983;Hughes et al, 1989;Nyberg et al, 1989;Tucci and Bard, 1990]. Because our experience with a large database, including 2,979 confirmed cases of DS, did not support their suggestion, we reviewed our own DS and omphalocele cases, those of other epidemiological studies, and those of surgical, clinical, and familial studies of omphalocele.…”

Section: Introductionmentioning

confidence: 99%

Is there an association of Down syndrome and omphalocele?

Torfs¹,

Honoré

Curry

1997

Am. J. Med. Genet.

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The possible association of Down syndrome (DS) with omphalocele is controversial. We reviewed the 2,979 live births and stillbirths with DS born from 1983 to 1993 in the catchment area of the California Birth Defects Monitoring Program (CBDMP). We observed one infant with both defects, a number that did not differ significantly from what was expected (P < 0.40). We also reviewed the pathological reports of one of us (L.H.H.) from a series of 36 DS fetuses and neonatal deaths; none had an omphalocele. We then reviewed the literature for epidemiological studies of DS and for epidemiological, surgical, prenatal, and familial studies of omphalocele. Possible biases inherent in each type of study were evaluated. The majority of epidemiological studies showed no association of DS with omphalocele. In surgical series, the occasional infant with both defects was more likely to undergo surgery than infants with omphalocele and trisomies 13 and 18 or other severe birth defects. Inclusion of both omphalocele and umbilical hernia in the same ICD-9 code may explain some of the correlations with DS noticed in a few epidemiological studies. In conclusion, our data suggest that trisomy 21 does not predispose the fetus to an increased risk for an omphalocele.

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“…Even term babies with gastroschisis are more likely to be small for gestational age 28,29,30 and to have younger mothers 31 Birth weight and gestational age are strong indicators of mortality. Low birth weight increases the risk of mortality 40 to 600 times.…”

Section: Discussionmentioning

confidence: 99%