Perinatal and neonatal morbidity among infants of diabetic mothers at a university hospital in Central Saudi Arabia

Alnemri, Abdulrahman; Alsohime, Fahd; Shaik, Asfaq H.; El-Hissi, Ghasan A.; Al-Agha, Mohammed I.; Al-Abdulkarim, Nada F.; Mohamed, Sarar

doi:10.15537/smj.2018.6.22907

Cited by 11 publications

(12 citation statements)

References 15 publications

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“…Sixteen studies were retrospective, two were prospective, one was cross-sectional and one was unspecified. Nine studies reported adverse outcomes for pregestational diabetes, combining data for T1DM and T2DM [ 16 , 20 , 22 , 25 , 27 , 43 , 44 , 45 , 46 ], while 11 studies reported data for T1DM and T2DM, separately [ 14 , 15 , 17 , 21 , 24 , 47 , 48 , 49 , 50 , 51 , 52 ]. These studies reported on various maternal and neonatal short-term pregnancy adverse outcomes, of which 13 are summarised in this review.…”

Section: Resultsmentioning

confidence: 99%

“…Of the studies that compared pregestational T1DM and T2DM separately with GDM, six studies reported higher rates of C/S in T1DM and T2DM compared to GDM [ 17 , 21 , 48 , 50 , 51 , 52 ]. Al-Nemri reported higher rates of elective C/S in pregestational T1DM (25.0%) and T2DM (34.3%) compared to GDM (15.7%), but similar rates for emergency C/S [ 14 ]. Petticca et al, 2009, reported higher rates of C/S in pregestational T1DM (51.6%) compared to pregestational T2DM (38.0%) and GDM (38.0%), with the latter diabetes types showing similar rates of C/S [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

“…It is widely reported that all types of maternal diabetes are associated with pregnancy complications; although, adverse outcomes are more common in women with pregestational diabetes [ 14 , 15 , 16 , 17 , 18 ]. As adverse pregnancy outcomes are closely related to poor glycaemic control and the first trimester being a critical period for organogenesis, it is speculated that preconception hyperglycaemia and the longer time of exposure to hyperglycaemia in utero may contribute to the complications associated with pregestational diabetes [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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A Systematic Review to Compare Adverse Pregnancy Outcomes in Women with Pregestational Diabetes and Gestational Diabetes

Malaza

Masete

Adam

et al. 2022

IJERPH

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Pregestational type 1 (T1DM) and type 2 (T2DM) diabetes mellitus and gestational diabetes mellitus (GDM) are associated with increased rates of adverse maternal and neonatal outcomes. Adverse outcomes are more common in women with pregestational diabetes compared to GDM; although, conflicting results have been reported. This systematic review aims to summarise and synthesise studies that have compared adverse pregnancy outcomes in pregnancies complicated by pregestational diabetes and GDM. Three databases, Pubmed, EBSCOhost and Scopus were searched to identify studies that compared adverse outcomes in pregnancies complicated by pregestational T1DM and T2DM, and GDM. A total of 20 studies met the inclusion criteria and are included in this systematic review. Thirteen pregnancy outcomes including caesarean section, preterm birth, congenital anomalies, pre-eclampsia, neonatal hypoglycaemia, macrosomia, neonatal intensive care unit admission, stillbirth, Apgar score, large for gestational age, induction of labour, respiratory distress syndrome and miscarriages were compared. Findings from this review confirm that pregestational diabetes is associated with more frequent pregnancy complications than GDM. Taken together, this review highlights the risks posed by all types of maternal diabetes and the need to improve care and educate women on the importance of maintaining optimal glycaemic control to mitigate these risks.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Systematic Review to Compare Adverse Pregnancy Outcomes in Women with Pregestational Diabetes and Gestational Diabetes

Malaza

Masete

Adam

et al. 2022

IJERPH

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“…Eight studies (9.9%) enrolled pregnant mothers at varying stages after delivery [24,49,58,59,81,84,88,99]. Seventeen studies (21.0%) recruited newborns at varying stages after birth [20,21,45,52,56,63,65,66,70,73,75,92,101,102,[105][106][107][108] such as preterm babies [20,66,73,105,108] (see Additional file 3: Table S2).…”

Section: Study Characteristicsmentioning

confidence: 99%

Maternal and birth cohort studies in the Gulf Cooperation Council countries: a systematic review and meta-analysis

et al. 2020

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Background: We systematically reviewed and chronicled exposures and outcomes measured in the maternal and birth cohort studies in the Gulf Cooperation Council (GCC) countries and quantitatively summarized the weighted effect estimates between maternal obesity and (1) cesarean section (CS) and (2) fetal macrosomia. Methods: We searched MEDLINE-PubMed, Embase, Cochrane Library, Scopus, and Web of Science electronic databases up to 30 June 2019. We considered all maternal and birth cohort studies conducted in the six GCC countries (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and United Arab Emirates (UAE)). We categorized cohort studies on the basis of the exposure(s) (anthropometric, environmental, medical, maternal/reproductive, perinatal, or socioeconomic) and outcome(s) (maternal or birth) being measured. Adjusted weighted effect estimates, in the form of relative risks, between maternal obesity and CS and fetal macrosomia were generated using a randomeffects model. Results: Of 3502 citations, 81 published cohort studies were included. One cohort study was in Bahrain, eight in Kuwait, seven in Qatar, six in Oman, 52 in Saudi Arabia, and seven in the UAE. Majority of the exposures studied were maternal/reproductive (65.2%) or medical (39.5%). Birth and maternal outcomes were reported in 82.7% and in 74.1% of the cohort studies, respectively. In Saudi Arabia, babies born to obese women were at a higher risk of macrosomia (adjusted relative risk (aRR), 1.15; 95% confidence interval (CI), 1.10-1.20; I 2 = 50%) or cesarean section (aRR, 1.21; 95% CI, 1.15-1.26; I 2 = 62.0%). Several cohort studies were only descriptive without reporting the magnitude of the effect estimate between the assessed exposures and outcomes. Conclusions: Cohort studies in the GCC have predominantly focused on reproductive and medical exposures. Obese pregnant women are at an increased risk of undergoing CS delivery or macrosomic births. Longer-term studies that explore a wider range of environmental and biological exposures and outcomes relevant to the GCC region are needed. Systematic review registration: PROSPERO CRD42017068910

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“…Previous studies shown that the incidence of congenital malformations was 2-5 times more in IDMs than in other infants with cardiac malformations. 17 The tendency towards incidence of congenital malformations might be due to poor diabetes control in the first and second trimester of pregnancy. This is because organogenesis occurs in early pregnancy that may lead to congenital malformation when infant is exposed to poor metabolic control during this period.…”

Section: Discussionmentioning

confidence: 99%

Study on neonatal morbidity in infants of diabetic mothers

Muthiah

Pyarejan

2020

Int J Contemp Pediatr

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Background: Many infants of diabetic mothers (IDMs) born with specific characteristics like macrosomia, hypoglycemia, respiratory distress syndrome (RDS) and other morbidity risks. The present study was done with the aim to determine morbidity and mortality pattern amongst IDMs admitted into the neonatal intensive care units (NICU) of our tertiary care center.Methods: Descriptive study was done on 86 infants in the NICU of Government RSRM lying in Hospital and Institute of Social Pediatrics, Govt Stanley Hospital, Chennai Tamil Nadu during the period from August 2007 to October 2008. Data on mode of delivery, gestational age, birth weight, other associated morbidities and investigation results were noted.Results: Among the 85 mothers, 67 mothers had gestational diabetes mellitus and 18 had diabetes mellitus preceding pregnancy. Among the 86 IDMs, 15 infants were macrosomic, 11 infants were premature, 12 had mild to severe RDS, 11 infants had hypoglycemia, 3 had hypocalcemia, 2 had birth injuries, 3 infants were born as small for gestational age. Polycythemia observed in 3 IDMs, hyperbilirubinemia in 8 infants, external congenital malformations in two infants and congenital heart disease in three infants.Conclusions: IDMs developed many complications in the study. Macrosomia was the major among them. Perinatal morbidities can be reduced by screening of diabetic mothers from first trimester, maintaining good glycaemic control and adequate management of their infants.

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Perinatal and neonatal morbidity among infants of diabetic mothers at a university hospital in Central Saudi Arabia

Cited by 11 publications

References 15 publications

A Systematic Review to Compare Adverse Pregnancy Outcomes in Women with Pregestational Diabetes and Gestational Diabetes

A Systematic Review to Compare Adverse Pregnancy Outcomes in Women with Pregestational Diabetes and Gestational Diabetes

Maternal and birth cohort studies in the Gulf Cooperation Council countries: a systematic review and meta-analysis

Study on neonatal morbidity in infants of diabetic mothers

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