Perinatal and childhood factors and risk of prostate cancer in adulthood: MCC-Spain case-control study

Lope, Virginia; García‐Esquinas, Esther; Ruiz-Dominguez, José Manuel; Llorca, Javier; Jiménez-Moleón, José Juan; Ruiz-Cerdá, J.L.; Alguacil, Juan; Tardón, Adonina; Dierssen-Sotos, Trinidad; Tabernero, A.; Mengual, Lourdes; Kogevinas, Manolis; Aragonés, Núria; Castaño‐Vinyals, Gemma; Pollán, Marina; Pérez‐Gómez, Beatriz

doi:10.1016/j.canep.2016.06.012

Cited by 9 publications

(10 citation statements)

References 35 publications

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“…In conclusion, PHIV youth experience delays in pubertal maturation that may have adverse long-term consequences, including reduced self-esteem and decreased bone mineral density, along with possible increased risks of some cancers [1,24,25,35]. The deficient growth experienced by PHIV children was found to be an important contributor to this negative effect.…”

Section: Discussionmentioning

confidence: 91%

“…Previous research has focused predominantly on associations of early puberty on adverse health outcomes [1, 24], but recent findings have indicated associations of delayed puberty with increased risk of specific cancers. For example, Lope and colleagues recently reported a 6% increase in risk of prostate cancer for each 1-year delay in pubertal onset in boys [25]. …”

Section: Discussionmentioning

confidence: 99%

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Delay in sexual maturation in perinatally HIV-infected youths is mediated by poor growth

Bellavia¹,

Williams²,

DiMeglio³

et al. 2017

Aids

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Objective To evaluate the association between HIV infection and sexual maturation, and mediation of this association by HIV effects on growth. Design Pooled data were analyzed from two longitudinal cohort studies, the IMPAACT P219/219C Study (1993–2007) and the PHACS Adolescent Master Protocol (2007–2015), including perinatally HIV-infected (PHIV) and HIV-exposed uninfected (PHEU) youth. Methods We evaluated age at sexual maturity among 2539 PHIV and PHEU adolescents based on annual physician-assessed pubertal staging measures. Interval-censored regression models were used to evaluate associations of HIV infection with age at maturity. Mediation analyses accounting for height and body mass index (BMI) Z-scores at specific ages were used to estimate direct and indirect effects of HIV infection on age at sexual maturity. Results Mean ages at sexual maturity for PHIV girls (n=1032) were 15.5 years for both female breast and pubic hair and 15.9 and 15.8 years for PHIV boys (n=1054) for genitalia and pubic hair, respectively. PHIV youth matured approximately 6 months later on average than PHEU (n=221 girls, 232 boys), and this difference persisted after adjustment for race/ethnicity and birth cohort. BMI and height Z-scores mediated the association between HIV infection and later maturation in girls, accounting for up to 74% of the total HIV effect. Only height Z-scores mediated the effect of HIV on male age at maturity, accounting for up to 98% of the HIV effect. Conclusion PHIV youth attain sexual maturity later on average than PHEU youth. Much of this difference may be attributable to deficient growth, suggesting directions for future interventions.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Delay in sexual maturation in perinatally HIV-infected youths is mediated by poor growth

Bellavia¹,

Williams²,

DiMeglio³

et al. 2017

Aids

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“…Controls with personal history of PC, from provinces that had not recruited PC cases and, within each province, those more than 5 years younger than the youngest PC case were excluded. Response rates were 52.2% for controls and 67.4% for PC cases 19 . We excluded 23 PC cases with Gleason <6.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 93%

“…The population-based multicase-control study MCC-Spain 18,19 recruited, between September 2008 and December 2013, histologically confirmed incident cases of five tumors (breast, prostate, colorectal, gastric and chronic lymphocytic leukemia) and a single set of populationbased controls, frequency matched by age and sex with the overall distribution of cases for each province. Inclusion criteria required that participants were 20-85 years old, were able to answer the questionnaire, and resided for at least 6 months in the study areas.…”

Section: Mcc-spainmentioning

confidence: 99%

Mediterranean Dietary Pattern is Associated with Low Risk of Aggressive Prostate Cancer: MCC-Spain Study

et al. 2018

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“…Although some studies have reported up to a 25% decrease in the odds of prostate cancer in individuals with later puberty, 109 -111 others have reported either no association 112,113 or up to a 6% increase in the odds of prostate cancer for each year of pubertal delay. 114 Difficulty in assessment of pubertal timing in men may be a contributor to the discrepant results; thus, 1 study used a genetic risk score calculated from 13 single nucleotide polymorphisms as a proxy for pubertal development. Although the researchers did not find a significant association between genetic risk score and the presence of prostate cancer, they did identify an association between a higher genetic risk score (later onset of puberty) and a 24% reduction in the odds of 9 OR up to 1.52, 95% CI: 1.12 to 2.05 for age at menarche 11.5 to 13.5 y vs ≥13.5 y, P = .007 [18][19] No difference in OR for age at menarche 11.5 to 13.5 y vs ≥13.…”

Section: Prostate Cancermentioning

confidence: 99%

Adult Consequences of Self-Limited Delayed Puberty

2017

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Delayed puberty is a common condition defined as the lack of sexual maturation by an age ≥2 SD above the population mean. In the absence of an identified underlying cause, the condition is usually self-limited. Although self-limited delayed puberty is largely believed to be a benign developmental variant with no long-term consequences, several studies have suggested that delayed puberty may in fact have both harmful and protective effects on various adult health outcomes. In particular, height and bone mineral density have been shown to be compromised in some studies of adults with a history of delayed puberty. Delayed puberty may also negatively affect adult psychosocial functioning and educational achievement, and individuals with a history of delayed puberty carry a higher risk for metabolic and cardiovascular disorders. In contrast, a history of delayed puberty appears to be protective for breast and endometrial cancer in women and for testicular cancer in men. Most studies on adult outcomes of self-limited delayed puberty have been in small series with significant variability in outcome measures and study criteria. In this article, we review potential medical and psychosocial issues for adults with a history of self-limited delayed puberty, discuss potential mechanisms underlying these issues, and identify gaps in knowledge and directions for future research.

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Perinatal and childhood factors and risk of prostate cancer in adulthood: MCC-Spain case-control study

Cited by 9 publications

References 35 publications

Delay in sexual maturation in perinatally HIV-infected youths is mediated by poor growth

Delay in sexual maturation in perinatally HIV-infected youths is mediated by poor growth

Mediterranean Dietary Pattern is Associated with Low Risk of Aggressive Prostate Cancer: MCC-Spain Study

Adult Consequences of Self-Limited Delayed Puberty

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