Perimicrovillar membranes promote hemozoin formation into Rhodnius prolixus midgut

Silva, José R.; Mury, Flávia Borges; Oliveira, Marcus F.; Oliveira, Pedro L.; Silva, Carlos P.; Dansa-Petretski, Marı́lvia

doi:10.1016/j.ibmb.2007.01.001

Cited by 24 publications

(46 citation statements)

References 65 publications

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“…These results are consistent with those reported by Damasceno-Sa et al (2007) who demonstrated using TEM and SEM studies that in starved D. peruvianus the microvilli were without PMM covering. Similar observations have also been reported for R. prolixus that the midgut cells of starved insects were almost deprived of PMMs Downe, 1983, 1986;Silva et al, 2007). Also, it has been reported that in D. fasciatus cytology of the midgut epithelium is changed in the starved insects (Khan and Ford, 1962).…”

Section: Developing Perimicrovillar Membrane In Eurygaster Integricepssupporting

confidence: 77%

“…These Cry toxins bind to aminopeptidase and cadherin receptors, producing pore in the cell membrane, and causing cell breakdown, and finally insect death (de Maagd et al, 2001;Bravo et al, 2007;Soberon et al, 2007). However, in some other insects, such as Hemiptera, aminopeptidase is in a soluble form as indicated for D. Peruvianus, E. Integriceps, and R. prolixus (Ferreira et al, 1988;Silva et al, 1996Silva et al, , 2007Damasceno-Sa et al, 2007;Allahyari et al, 2010).…”

Section: Developing Perimicrovillar Membrane In Eurygaster Integricepsmentioning

confidence: 99%

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Secretion and formation of perimicrovillar membrane in the digestive system of the Sunn pest, Eurygaster integriceps (Hemiptera: Scutelleridae) in response to feeding

Mehrabadi

Bandani

2011

Arch Insect Biochem Physiol

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In this study, development of perimicrovillar membrane (PMM) from midgut cells of starved and fed Eurygaster integriceps (Hemiptera: Scutelleridae) was studied. Three different approaches, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), marker enzymes of the PMMs (α-glucosidase), perimicrovillar space (aminopeptidase), and microvillar membranes (β-glucosidase) were used. Activities of these enzymes were remarkably low in the starved insects. Moreover, microscopic observations revealed that PMM is not present in the starved insect. Activities of enzymatic markers increased at 5 h postfeeding, and TEM and SEM observations showed the formation of PMM as well as migration of double-membrane vesicles from center of the columnar cell to the cell apex. The highest PMM was observed at 20 h postfeeding which at this time marker enzyme activity, such as α-glucosidase activity, was high, too. Thus, at 20 h postfeeding, PMM system was evident and epithelial cells were completely covered by PMM system. After 20 h postfeeding, presence of the fine holes in PMM started to be seen and at 40 h post-feeding, observation showed degradation of PMM system. Thus, it could be concluded that PMM in E. integriceps is secreted by epithelial cell membrane when needed and its secretion and formation is regulated by feeding. This system was not present in the starved insects as its development takes place at 5 h postfeeding.

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Section: Developing Perimicrovillar Membrane In Eurygaster Integricepssupporting

confidence: 77%

Section: Developing Perimicrovillar Membrane In Eurygaster Integricepsmentioning

confidence: 99%

Secretion and formation of perimicrovillar membrane in the digestive system of the Sunn pest, Eurygaster integriceps (Hemiptera: Scutelleridae) in response to feeding

Mehrabadi

Bandani

2011

Arch Insect Biochem Physiol

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“…4B). Previous observations show that in R. prolixus Hz crystals are found in close association with PMVM (Oliveira et al, 2005Silva et al, 2007) in such a way that its formation depends on the presence of this structure (Oliveira et al, 2000a). Fig.…”

Section: Lipids Derived From R Prolixus Midgut Are Efficient Catalysmentioning

confidence: 72%

“…There is a general consensus in the literature that amphipathic structures, such as lipid droplets (Oliveira et al, 2005;Corrêa Soares et al, 2007;Pisciotta et al, 2007) and phospholipid membranes (Oliveira et al, 1999(Oliveira et al, , 2000a(Oliveira et al, , 2005Silva et al, 2007) play a key role in heme crystallization. In this regard, heme crystallization in the helminth S. mansoni occurs on the surface of extracellular lipid droplets present in the gut lumen (Oliveira et al, 2000b;Corrêa Soares et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…In fact, lipid-driven heme crystallization to Hz has been reported since 1995, when Bendrat et al (1995) showed that an acetonitrile extract from Plasmodium food vacuoles were able to produce this heme crystal. Investigations over the mechanism of Hz formation by PMVM were further carried out by Silva et al (2007), which demonstrated that both a lipid extract and a protein fraction from PMVM were able to promote heme crystallization in vitro. However, Hz formation driven by PMVM-derived lipids in that work was significantly lower compared to the activity supported by native PMVM.…”

Section: Introductionmentioning

confidence: 99%

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On the physico-chemical and physiological requirements of hemozoin formation promoted by perimicrovillar membranes in Rhodnius prolixus midgut

Stiebler

Timm

Oliveira

et al. 2010

Insect Biochemistry and Molecular Biology

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Malaria Pigment Crystals: The Achilles′ Heel of the Malaria Parasite

et al. 2021

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The biogenic formation of hemozoin crystals, a crucial process in heme detoxification by the malaria parasite, is reviewed as an antimalarial drug target. We first focus on the in‐vivo formation of hemozoin. A model is presented, based on native‐contrast 3D imaging obtained by X‐ray and electron microscopy, that hemozoin nucleates at the inner membrane leaflet of the parasitic digestive vacuole, and grows in the adjacent aqueous medium. Having observed quantities of hemoglobin and hemozoin in the digestive vacuole, we present a model that heme liberation from hemoglobin and hemozoin formation is an assembly‐line process. The crystallization is preceded by reaction between heme monomers yielding hematin dimers involving fewer types of isomers than in synthetic hemozoin; this is indicative of protein‐induced dimerization. Models of antimalarial drugs binding onto hemozoin surfaces are reviewed. This is followed by a description of bromoquine, a chloroquine drug analogue, capping a significant fraction of hemozoin surfaces within the digestive vacuole and accumulation of the drug, presumably a bromoquine–hematin complex, at the vacuole's membrane.

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Perimicrovillar membranes promote hemozoin formation into Rhodnius prolixus midgut

Cited by 24 publications

References 65 publications

Secretion and formation of perimicrovillar membrane in the digestive system of the Sunn pest, Eurygaster integriceps (Hemiptera: Scutelleridae) in response to feeding

Secretion and formation of perimicrovillar membrane in the digestive system of the Sunn pest, Eurygaster integriceps (Hemiptera: Scutelleridae) in response to feeding

On the physico-chemical and physiological requirements of hemozoin formation promoted by perimicrovillar membranes in Rhodnius prolixus midgut

Malaria Pigment Crystals: The Achilles′ Heel of the Malaria Parasite

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