Perimenopausal changes in serum lipids and lipoproteins: A 7-year longitudinal study

Fukami, Kazuyuki; Koike, Koji; Hirota, Kenji; Yoshikawa, Hiromichi; Miyake, Akira

doi:10.1016/0378-5122(95)00927-d

Cited by 60 publications

(29 citation statements)

References 13 publications

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“…One possible explanation for it is due to the sex hormonal changes during menopausal transition [2], and another is due to the alteration of serum lipid profile, for instance an increase of low-density lipoprotein (LDL) cholesterol (LDL-C) [3][4][5]. Acceleration of atherogenic lipid profile is currently recognized among postmenopausal women, and so in preventing CVD, there is an increasing importance on understanding the characteristics of lipid profile especially at earlier stages of menopausal transition such as perimenopause [4].…”

Section: Introductionmentioning

confidence: 99%

Correlation Pattern of Serum Lipid Parameters and a Biological Anti-Oxidant Potential Between Premenopausal and Perimenopausal Healthy Women

Chen¹,

Kotani²

2017

J. Biomed

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Objectives. Improved understanding of the associations among cardiometabolic, antioxidative, and menopausal status is crucial to prevent cardiovascular disease (CVD). For preventing the development of CVD in women, the association of serum lipid profile and antioxidant parameters during menopausal transition is of interest. The aim of the study is to evaluate the correlation between lipid and antioxidant levels especially in premenopausal and perimenopausal women. Methods. A total of 130 CVD-free healthy women; the premenopausal group (n = 51, mean 41 years) and perimenopausal group (n = 79, mean 49 years) were studied. A biological antioxidant potential (BAP) test was utilized for measuring antioxidant levels. The association between lipid and BAP levels was examined by linear correlation analyses. Results. The perimenopausal group showed a significantly higher low-density lipoprotein cholesterol (LDL-C) level than the premenopausal group (mean 123 vs. 111 mg/dL, p < 0.05), while there were no significant differences in triglyceride, high-density lipoprotein cholesterol and BAP levels between the groups. A significant inverse correlation existed between LDL-C and BAP levels in the perimenopausal group (β = -0.30, p < 0.05), but not in the premenopausal group.Conclusions. The correlation patterns between lipid parameters and antioxidant levels demarcated the premenopausal from perimenopausal stage. Increased LDL-C associated with decreased antioxidant levels in perimenopausal women may call early attention for cardiovascular health.

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Section: Introductionmentioning

confidence: 99%

Correlation Pattern of Serum Lipid Parameters and a Biological Anti-Oxidant Potential Between Premenopausal and Perimenopausal Healthy Women

Chen¹,

Kotani²

2017

J. Biomed

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“…1,2 Part of this increased risk is likely to be due to adverse changes in lipids and (apo)lipoproteins after menopause. Levels of total cholesterol, LDL, triglycerides, and apoB have been reported to increase, 3,4 probably (at least partly) because of a reduction in LDL receptor activity in response to the gradual decline in blood estrogen levels in the perimenopausal years. 5,6 Levels of lipids, lipoproteins, and apolipoproteins, which have been established as important predictors of atherosclerotic coronary disease, 7 vary considerably over a lifespan, and their phenotypic variance generally shows an increase with age.…”

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confidence: 99%

Genetic and Environmental Influences on Lipids, Lipoproteins, and Apolipoproteins

Middelberg

Spector

Swaminathan

et al. 2002

ATVB

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Objective-Levels of lipids and (apo)lipoproteins are known to increase after menopause, but it is unknown whether the genetic and environmental variability alters or whether lipids and (apo)lipoproteins are influenced by different genes before and after menopause. Methods and Results-We studied 453 monozygotic and 1280 dizygotic pairs of female white twins recruited from the St. Thomas' UK Adult Twin Registry and measured total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), triglycerides, lipoprotein(a) [Lp(a)], apolipoprotein A1 (apoA1), and apolipoprotein B (apoB).Variance components software was used to estimate genetic and environmental influences on serum lipid levels in premenopausal and postmenopausal women. Total variance was higher for triglycerides, HDL, and apoB after menopause. Postmenopausal women showed larger genetic variance for most lipids, apart from apoB and Lp(a). In premenopausal females, total cholesterol, LDL, HDL, apoA1, and apoB all showed an influence of the shared environment (22% to 34%), which, after menopause, decreased in HDL and completely disappeared in total cholesterol, LDL, and apoA1. Only for Lp(a), with a high heritability of 87%, did the same model fit premenopausal and postmenopausal women. Generally, there was no indication that different genes influence lipids before and after menopause. Key Words: lipids Ⅲ genetics Ⅲ twin study Ⅲ menopause P ostmenopausal women are 2 to 3 times more likely to suffer from coronary heart disease than are premenopausal women. 1,2 Part of this increased risk is likely to be due to adverse changes in lipids and (apo)lipoproteins after menopause. Levels of total cholesterol, LDL, triglycerides, and apoB have been reported to increase, 3,4 probably (at least partly) because of a reduction in LDL receptor activity in response to the gradual decline in blood estrogen levels in the perimenopausal years. 5,6 Levels of lipids, lipoproteins, and apolipoproteins, which have been established as important predictors of atherosclerotic coronary disease, 7 vary considerably over a lifespan, and their phenotypic variance generally shows an increase with age. 8 -11 Such an increase in lipid and (apo)lipoprotein variance may be due to interindividual variation in the rise of lipid levels over time, and several studies now indicate that different genetic and/or environmental factors are likely to be involved at different ages. 10,12,13 Superimposed on the global change across the whole lifespan, 4 specific time periods are associated with more dramatic changes. Menopause is one of these; the others are old age, adolescence, and the first years after birth. Conclusions-TheseWe recently reviewed twin studies of lipids and (apo)lipoproteins and showed that most studies report heritability (h 2 ) estimates between 40% and 80% for total cholesterol, LDL, HDL, triglycerides, apoA1, and apoB, with Lp(a) h 2 values of Ϸ90%. 11 Only one study, which reported on HDL alone, focused on the effect of menopause and found that postmenopausal m...

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“…Both natural and surgical menopause cause changes in serum lipids that are explained by the deficiency of oestrogens: serum total and LDL cholesterol and triglyceride levels increase and HDL cholesterol levels decrease (Matthews et al, 1989;Newnhamn 1993;Stevenson et al, 1993;Schaefer et al, 1994;Fukami et al, 1995). These adverse effects of menopause on serum lipids are reversed by hormone replacement therapy (Rijpkema et al, 1990;Nabulsi et al, 1993;Newnhamn, 1993;Writing Group for the PEPI Trial, 1995;Pripp et al, 1999).…”

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confidence: 99%

Tamoxifen treatment reverses the adverse effects of chemotherapy-induced ovarian failure on serum lipids

et al. 2004

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In all, 146 premenopausal women with early stage breast cancer were treated with adjuvant chemotherapy. In addition, 5-year tamoxifen treatment was started after chemotherapy to those 112 patients with hormone-receptor-positive tumours while those with hormone-receptor-negative tumours received no further therapy. The serum lipid levels were followed in both groups. The levels of serum total and low-density lipoprotein (LDL) cholesterol increased significantly after chemotherapy only in patients who developed ovarian dysfunction. Total cholesterol increased þ 9.5% and LDL cholesterol þ 16.6% in patients who developed amenorrhoea (Po0.00001 and 0.00001, respectively). The cholesterol levels did not change in patients who preserved regular menstruation after chemotherapy. After 6 months of tamoxifen therapy, the total cholesterol decreased À9.7% and the LDL cholesterol À16.7% from levels after the chemotherapy, while the cholesterol concentrations remained at increased levels in the control group (P ¼ 0.001 and Po0.0001, respectively). The high-density lipoprotein cholesterol levels did not change significantly in either tamoxifen or control group. The effects of tamoxifen treatment on serum lipids after chemotherapy have not been studied before. Our current study suggests that adjuvant tamoxifen therapy reverses the adverse effects of chemotherapy-induced ovarian failure on total and LDL cholesterol and even lowers their serum levels below the baseline.

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Perimenopausal changes in serum lipids and lipoproteins: A 7-year longitudinal study

Cited by 60 publications

References 13 publications

Correlation Pattern of Serum Lipid Parameters and a Biological Anti-Oxidant Potential Between Premenopausal and Perimenopausal Healthy Women

Correlation Pattern of Serum Lipid Parameters and a Biological Anti-Oxidant Potential Between Premenopausal and Perimenopausal Healthy Women

Genetic and Environmental Influences on Lipids, Lipoproteins, and Apolipoproteins

Tamoxifen treatment reverses the adverse effects of chemotherapy-induced ovarian failure on serum lipids

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