Perilla frutescens Sprout Extract Protect Renal Mesangial Cell Dysfunction against High Glucose by Modulating AMPK and NADPH Oxidase Signaling

Kim, Ha-Rim; Kim, Seon‐Young

doi:10.3390/nu11020356

Cited by 13 publications

(9 citation statements)

References 36 publications

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“…Resveratrol treatment in db/db mice prevented NOX4 expression primarily due to increased AMPK activity [132]. Similarly, numerous recent studies highlighted the beneficial effects of antioxidants or other compounds against renal injuries implicating AMPK/NOX4/ROS [133][134][135][136][137][138][139]. Furthermore, two independent studies reported that Sestrin-2 mediated activation of AMPK inhibits ROS production, podocyte impairment in the hyperglycemic condition, and suppresses NOX4 in glomerular mesangial cells [140,141].…”

Section: Ampk and Oxidative Stressmentioning

confidence: 95%

Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease

Juszczak

Caron

Mathew

et al. 2020

IJMS

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Chronic kidney disease (CKD) is prevalent in 9.1% of the global population and is a significant public health problem associated with increased morbidity and mortality. CKD is associated with highly prevalent physiological and metabolic disturbances such as hypertension, obesity, insulin resistance, cardiovascular disease, and aging, which are also risk factors for CKD pathogenesis and progression. Podocytes and proximal tubular cells of the kidney strongly express AMP-activated protein kinase (AMPK). AMPK plays essential roles in glucose and lipid metabolism, cell survival, growth, and inflammation. Thus, metabolic disease-induced renal diseases like obesity-related and diabetic chronic kidney disease demonstrate dysregulated AMPK in the kidney. Activating AMPK ameliorates the pathological and phenotypical features of both diseases. As a metabolic sensor, AMPK regulates active tubular transport and helps renal cells to survive low energy states. AMPK also exerts a key role in mitochondrial homeostasis and is known to regulate autophagy in mammalian cells. While the nutrient-sensing role of AMPK is critical in determining the fate of renal cells, the role of AMPK in kidney autophagy and mitochondrial quality control leading to pathology in metabolic disease-related CKD is not very clear and needs further investigation. This review highlights the crucial role of AMPK in renal cell dysfunction associated with metabolic diseases and aims to expand therapeutic strategies by understanding the molecular and cellular processes underlying CKD.

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Section: Ampk and Oxidative Stressmentioning

confidence: 95%

Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease

Juszczak

Caron

Mathew

et al. 2020

IJMS

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“…Interestingly Perilla extracts also increased keratinocyte proliferation, which suggests that they might protect against keratinocyte aging. The antioxidant effects of Perilla leaf extracts have been previously studied in pharmacological properties [ 7 ]. Perilla leaf has been used as a traditional medicine to treat depression, anxiety, tumors, coughs, allergies, and other conditions, and our findings suggest that Perilla leaf and callus extracts could be used to treat keratinocyte damage and UV exposure-induced keratinocyte conditions [ 6 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Perilla frutescens (Perilla) is an annual herb widely cultured in Asia. Perilla leaves are known to have antioxidant, anti-inflammatory, and anti-allergic effects and to be rich in polyphenols [ 6 , 7 ]. Calluses (as known as plant stem cells) are disorganized, non-differentiated plant cell masses and are induced using hormones, such as auxin or cytokinin from plant explants [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Perilla frutescens Extracts Enhance DNA Repair Response in UVB Damaged HaCaT Cells

Lee

Park

2021

Nutrients

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Physiological processes in skin are associated with exposure to UV light and are essential for skin maintenance and regeneration. Here, we investigated whether the leaf and callus extracts of Perilla frutescens (Perilla), a well-known Asian herb, affect DNA damage response and repair in skin and keratinocytes exposed to Untraviolet B (UVB) light. First, we examined the protective effects of Perilla leaf extracts in UVB damaged mouse skin in vivo. Second, we cultured calluses using plant tissue culture technology, from Perilla leaf explant and then examined the effects of the leaf and callus extracts of Perilla on UVB exposed keratinocytes. HaCaT cells treated with leaf and callus Perilla extracts exhibited antioxidant activities, smaller DNA fragment tails, and enhanced colony formation after UVB exposure. Interestingly, keratinocytes treated with the leaf and callus extracts of Perilla showed G1/S cell cycle arrest, reduced protein levels of cyclin D1, Cyclin Dependent Kinase 6 (CDK6), and γH2AX, and enhanced levels of phosphorylated checkpoint kinase 1 (pCHK1) following UVB exposure. These observations suggest that the leaf and callus extracts of Perilla are candidate nutraceuticals for the prevention of keratinocyte aging.

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“…These findings show that HIF1α also contributed to the increase in NOX4 activity in this study. In this context, several studies have reported that NOX4 and AMPKα are inversely correlated in cardiac ventricular tissue, renal mesangial cells and podocytes [ 32 , 56 , 57 ]. Our work also shows that NOX4 hyperactivation leads to disturbances in AMPKα phosphorylation in adipocytes.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress resulting from the removal of endogenous catalase induces obesity by promoting hyperplasia and hypertrophy of white adipocytes

et al. 2020

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Obesity is regarded as an abnormal expansion and excessive accumulation of fat mass in white adipose tissue. The involvement of oxidative stress in the development of obesity is still unclear. Although mainly present in peroxisomes, catalase scavenges intracellular H 2 O 2 at toxic levels. Therefore, we used catalase-knockout (CKO) mice to elucidate the involvement of excessive H 2 O 2 in the development of obesity. CKO mice with C57BL/6J background gained more weight with higher body fat mass with age than age-matched wild-type (WT) mice fed with either chow or high-fat diets. This phenomenon was attenuated by concomitant treatment with the antioxidants, melatonin or N -acetyl cysteine. Moreover, CKO mouse embryonic fibroblasts (MEFs) appeared to differentiate to adipocytes more easily than WT MEFs, showing increased H 2 O 2 concentrations. Using 3T3-L1-derived adipocytes transfected with catalase-small interfering RNA, we confirmed that a more prominent lipogenesis occurred in catalase-deficient cells than in WT cells. Catalase-deficient adipocytes presented increased nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) expression but decreased adenosine monophosphate-activated protein kinase (AMPK) expression. Treatment with a NOX4 inhibitor or AMPK activator rescued the propensity for obesity of CKO mice. These findings suggest that excessive H 2 O 2 and related oxidative stress increase body fat mass via both adipogenesis and lipogenesis. Manipulating NOX4 and AMPK in white adipocytes may be a therapeutic tool against obesity augmented by oxidative stress.

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Perilla frutescens Sprout Extract Protect Renal Mesangial Cell Dysfunction against High Glucose by Modulating AMPK and NADPH Oxidase Signaling

Cited by 13 publications

References 36 publications

Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease

Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease

Perilla frutescens Extracts Enhance DNA Repair Response in UVB Damaged HaCaT Cells

Oxidative stress resulting from the removal of endogenous catalase induces obesity by promoting hyperplasia and hypertrophy of white adipocytes

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