Perilesional Hyperintensity on T1‐Weighted Images in Intra‐Axial Brain Masses other than Cavernous Malformations

Nabavizadeh, Seyed Ali; Pechersky, Dasha Darina; Schmitt, J. Eric; Nasrallah, MacLean P.; Loevner, Laurie A.; Mamourian, Alexander C.

doi:10.1111/jon.12424

Cited by 3 publications

(4 citation statements)

References 21 publications

(31 reference statements)

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“… [3] were the first to report it as a supporting finding to distinguish CMs from other hemorrhagic masses with high specificity and selectivity. There have also been reported cases of similar findings in patients with METs or non-neoplastic intracerebral hemorrhages [ 1 , 2 ]. However, there are no current reports of primary adult-type circumscribed/diffuse gliomas presenting with perilesional T1 HIA so far.…”

Section: Discussionmentioning

confidence: 74%

“…Perilesional T1 hyperintense areas (HIA) around lesions have been reported as a valuable sign for the differential diagnosis of hemorrhagic masses. This sign has been reported in cavernous malformations (CMs) and metastatic brain tumors (METs) but not primary diffuse gliomas [1] , [2] , [3] . We report a case of primary diffuse glioma that showed a perilesional T1 HIA and was difficult to distinguish from CM.…”

Section: Introductionmentioning

confidence: 82%

“…Typical perilesional brain edema appears at T1 hypo-intensity and T2 hyperintensity on MRI. Substances that exhibit T1 HIA are methemoglobin, melanin, lipids, proteins, minerals, and other variants [14] , with red blood cells, plasma, and proteins due to extravascular leakage also playing a potential role [ 1 , 3 ]. The T2*WI did not show a signal drop at the perilesional edema in our case, supporting the idea that leaking proteins were the cause of the perilesional T1 HIA.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Significance of perilesional T1 hyperintense areas in the differential diagnosis of primary adult-type diffuse glioma: A case report

Yamano

Yanaka

Onuma

et al. 2023

Radiology Case Reports

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Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Significance of perilesional T1 hyperintense areas in the differential diagnosis of primary adult-type diffuse glioma: A case report

Yamano

Yanaka

Onuma

et al. 2023

Radiology Case Reports

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“…In addition, the majority but not all CASH exhibited the T1 hyperintense perilesional signal, an imaging feature with moderate sensitivity and high sensitivity for the diagnosis of hemorrhagic CCM [ 29 ]. Nevertheless, it is important to be aware that this imaging sign may also be evident in other lesions, such as melanoma and other hemorrhagic metastasis [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Natural history of familial cerebral cavernous malformation syndrome in children: a multicenter cohort study

et al. 2022

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Purpose There is limited data concerning neuroimaging findings and longitudinal evaluation of familial cerebral cavernous malformations (FCCM) in children. Our aim was to study the natural history of pediatric FCCM, with an emphasis on symptomatic hemorrhagic events and associated clinical and imaging risk factors. Methods We retrospectively reviewed all children diagnosed with FCCM in four tertiary pediatric hospitals between January 2010 and March 2022. Subjects with first available brain MRI and $$\ge$$ ≥ 3 months of clinical follow-up were included. Neuroimaging studies were reviewed, and clinical data collected. Annual symptomatic hemorrhage risk rates and cumulative risks were calculated using survival analysis and predictors of symptomatic hemorrhagic identified using regression analysis. Results Forty-one children (53.7% males) were included, of whom 15 (36.3%) presenting with symptomatic hemorrhage. Seven symptomatic hemorrhages occurred during 140.5 person-years of follow-up, yielding a 5-year annual hemorrhage rate of 5.0% per person-year. The 1-, 2-, and 5-year cumulative risks of symptomatic hemorrhage were 7.3%, 14.6%, and 17.1%, respectively. The latter was higher in children with prior symptomatic hemorrhage (33.3%), CCM2 genotype (33.3%), and positive family history (20.7%). Number of brainstem (adjusted hazard ratio [HR] = 1.37, P = 0.005) and posterior fossa (adjusted HR = 1.64, P = 0.004) CCM at first brain MRI were significant independent predictors of prospective symptomatic hemorrhage. Conclusion The 5-year annual and cumulative symptomatic hemorrhagic risk in our pediatric FCCM cohort equals the overall risk described in children and adults with all types of CCM. Imaging features at first brain MRI may help to predict potential symptomatic hemorrhage at 5-year follow-up.

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Hemorrhage owing to cerebral cavernous malformation: imaging, clinical, and histopathological considerations

et al. 2020

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Perilesional Hyperintensity on T1‐Weighted Images in Intra‐Axial Brain Masses other than Cavernous Malformations

Abstract: Perilesional hyperintensity on T1-weighted imaging is not limited to cavernous malformations and frequently evident with melanoma and other hemorrhagic metastasis to the brain. In our experience, it was not seen in high-grade glioma, PCNSL, and brain abscess.

Cited by 3 publications

References 21 publications

Significance of perilesional T1 hyperintense areas in the differential diagnosis of primary adult-type diffuse glioma: A case report

Significance of perilesional T1 hyperintense areas in the differential diagnosis of primary adult-type diffuse glioma: A case report

Natural history of familial cerebral cavernous malformation syndrome in children: a multicenter cohort study

Hemorrhage owing to cerebral cavernous malformation: imaging, clinical, and histopathological considerations

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