Perilesional apparent diffusion coefficient in the preoperative evaluation of glioma grade

Yazdani, Milad; Rumboldt, Zoran; Tabesh, Ali; Giglio, Pierre; Schiarelli, Chiara; Morgan, Paul S.; Spampinato, Maria Vittoria

doi:10.1016/j.clinimag.2018.07.005

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…The results of our study showed that there was a statistically significant difference in ADC values adjacent to the enhancing mass between the patients stratified according to the survival times, which corresponds to the findings of Yazdani et al [15]. Several other studies have also shown that lower diffusivity suggests a high-grade glioma, and higher ADC values are indicative of a low-grade glioma, which is in accordance with the more cellular areas exhibiting lower water mobility [13,17,18].…”

Section: Discussionsupporting

confidence: 90%

“…Tissues with high cellularity have low ADC values (low diffusivity) as the mobility of water protons is impeded [3,[12][13][14]. It has been shown that ADC values in the regions surrounding the neoplastic signal abnormality allow for differentiation of low-grade from high-grade gliomas [15]. Additionally, significantly elevated diffusivity was found in the contralateral normal-appearing white matter (NAWM) of glioma patients, grades II to IV [16].…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Value of Apparent Diffusion Coefficient (ADC) in Patients with Diffuse Gliomas

Bušić,

Rumboldt,

Čerina

et al. 2024

Cancers

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This study aimed to evaluate potential posttreatment changes in ADC values within the tissue surrounding the enhancing lesion, particularly in areas not exhibiting MRI characteristics of involvement. Additionally, the objective was to investigate the correlations among ADC values, treatment response, and survival outcomes in individuals diagnosed with gliomas. This retrospective study included a total of 49 patients that underwent either stereotactic biopsy or maximal surgical resection. Histologically confirmed as Grade III or IV gliomas, all cases adhered to the 2016 and 2021 WHO classifications, with subsequent radio-chemotherapy administered post-surgery. Patients were divided into two groups: short and long survival groups. Baseline and follow-up MRI scans were obtained on a 1.5 T MRI scanner. Two ROI circles were positioned near the enhancing area, one ROI in the NAWM ipsilateral to the neoplasm and another symmetrically in the contralateral hemisphere on ADC maps. At follow-up there was a significant difference in both ipsilateral and contralateral NAWM between the two groups, −0.0857 (p = 0.004) and −0.0607 (p = 0.037), respectively. There was a weak negative correlation between survival and ADC values in ipsilateral and contralateral NAWM at the baseline with the correlation coefficient −0.328 (p = 0.02) and −0.302 (p = 0.04), respectively. The correlation was stronger at the follow-up. The findings indicate that ADC values in normal-appearing white matter (NAWM) may function as a prognostic biomarker in patients with diffuse gliomas.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Apparent Diffusion Coefficient (ADC) in Patients with Diffuse Gliomas

Bušić,

Rumboldt,

Čerina

et al. 2024

Cancers

Self Cite

View full text Add to dashboard Cite

show abstract

“…Ahmet et al 23 demonstrated that the size and Fuhrman grade of the clear cell renal cell carcinoma were inversely correlated with the ADC value. Yazdani et al 24 showed that significantly lower mean ADC values in high-grade compared to low-grade gliomas. Zhu et al 25 also reported that the ADC values of poorly differentiated esophageal carcinoma were lower than moderately differentiated and well-differentiated groups.…”

Section: Discussionmentioning

confidence: 99%

Associations Between Apparent Diffusion Coefficient Value With Pathological Type, Histologic Grade, and Presence of Lymph Node Metastases of Esophageal Carcinoma

Wang

Bai

Guo

et al. 2019

Technol Cancer Res Treat

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Objective: To investigate the application value of apparent diffusion coefficient value in the pathological type, histologic grade, and presence of lymph node metastases of esophageal carcinoma. Materials and Methods: Eighty-six patients with pathologically confirmed esophageal carcinoma were divided into different groups according to pathological type, histological grade, and lymph node status. All patients underwent conventional magnetic resonance imaging and diffusion-weighted imaging scan, and apparent diffusion coefficient values of tumors were measured. Independent sample t test and 1-way variance were used to compare the difference of apparent diffusion coefficient value in different pathological types, histologic grades, and lymph node status. Correlation between the apparent diffusion coefficient value and the histologic grade was evaluated using Spearman rank correlation test. Receiver operating characteristic curve of apparent diffusion coefficient value was generated to evaluate the differential diagnostic efficiency of poorly and well/moderately differentiated esophageal carcinoma. Results: No significant difference was observed in apparent diffusion coefficient value between esophageal squamous cell carcinoma and adenocarcinoma and in patients between those with and without lymph node metastases ( P > .05). The differences of apparent diffusion coefficient value were statistically significant between different histologic grades of esophageal carcinoma ( P < .05). The apparent diffusion coefficient value was positively correlated with histologic grade ( rs = 0.802). The apparent diffusion coefficient value ≤1.25 × 10−3 mm2/s as the cutoff value for diagnosis of poorly differentiated esophageal carcinoma with the sensitivity of 84.3%, and the specificity was 94.3%. Conclusions: The performance of apparent diffusion coefficient value was contributing to predict the histologic grade of esophageal carcinoma, which might increase lesions characterization before choosing the best therapeutic alternative. However, they do not correlate with pathological type and the presence of lymph node metastases of esophageal carcinoma.

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Transferrin receptor 1 targeted optical imaging for identifying glioma margin in mouse models

Zhao

Cai

et al. 2020

J Neurooncol

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Perilesional apparent diffusion coefficient in the preoperative evaluation of glioma grade

Cited by 4 publications

References 29 publications

Prognostic Value of Apparent Diffusion Coefficient (ADC) in Patients with Diffuse Gliomas

Prognostic Value of Apparent Diffusion Coefficient (ADC) in Patients with Diffuse Gliomas

Associations Between Apparent Diffusion Coefficient Value With Pathological Type, Histologic Grade, and Presence of Lymph Node Metastases of Esophageal Carcinoma

Transferrin receptor 1 targeted optical imaging for identifying glioma margin in mouse models

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