Periimplant Bone Response in Human-Retrieved, Clinically Stable, Successful, and Functioning Dental Implants After a Long-Term Loading Period

Iezzi, Giovanna; Piattelli, Adriano; Mangano, Carlo; Degidi, Marco; Testori, Tiziano; Vantaggiato, Giovanni; Fiera, Elisabetta; Frosecchi, Massimo; Floris, Pierluigi; Perroni, Roberto; Ravera, Lorenzo; Moreno, Gerardo Gómez; Martinis, Emanuele De

doi:10.1097/id.0000000000000415

Cited by 17 publications

(24 citation statements)

References 25 publications

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“…However, a large number of reports on histometric analyses of retrieved implants are available . Among these, one study reported data on 17 implants loaded between 4 and 20 years that were retrieved for different reasons from patients and prepared for histometric analyses . All implants were integrated into bone with bone‐to‐implant contact percentages ranging from 32% to 85%.…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8][9][10][11] Among these, one study reported data on 17 implants loaded between 4 and 20 years that were retrieved for different reasons from patients and prepared for histometric analyses. 11 All implants were integrated into bone with bone-to-implant contact percentages ranging from 32% to 85%. Also, various animal experiments have attempted to analyse the effect of immediately or delayed loading on osseointegration.…”

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confidence: 99%

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Immediate and delayed loading of fixed dental prostheses supported by single or two splinted implants: A histomorphometric study in dogs

Cesaretti

Lang

Viganó

et al. 2018

J of Oral Rehabilitation

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To evaluate presumptive differences in osseointegration at implants supporting crowns that are physiologically loaded either immediately or 3 months after installation. All premolars and first molars were extracted bilaterally in six dogs. After 3 months of healing, three implants were installed on the premolar region and two in the molar region in one side of the mandible. Likewise, after another 3 months, five implants were installed in the contralateral side, and impressions were taken bilaterally. Within 48 hours, two single crowns were screwed bilaterally onto two implants in the premolar region, and two splinted crowns reproducing the shape of the first molar were screwed bilaterally onto the implants in the molar region. The mesial implants were used as no-loaded controls. Sacrifices were performed after 3 months, and histological analyses were performed. At the premolar sites, mineralised bone-to-implant contact (MBIC%) was 78.0 ± 4.0% and 70.9 ± 7.9% at the delayed and immediately loaded sites, respectively. This difference was statistically significant. At the control implants, MBIC% was 61.4 ± 14.7% and 63.1 ± 13.1% at the delayed and the immediately loaded sites, respectively. At the molar sites, MBIC% was 79.2 ± 10.9% and 61.1 ± 10.3% at the delayed and immediately loaded sites, respectively. Applying a delayed loading to fixed dental prostheses supported by single or two splinted implants yielded higher proportions of bone-to-implant contact (osseointegration) compared to immediately loaded implants. Moreover, both types of loading protocols yielded a higher rate of osseointegration compared to unloaded implant sites after 3 months following implant installation.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Immediate and delayed loading of fixed dental prostheses supported by single or two splinted implants: A histomorphometric study in dogs

Cesaretti

Lang

Viganó

et al. 2018

J of Oral Rehabilitation

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“…Osseointegration has been reported to be a dynamic process in which the alveolar bone come in direct contact with the placed implant surface. 1 This phenomenon has also been demonstrated in various preclinical models 2,3 and histologic reports in a few humans. [4][5][6] However, the status of osseointegration does not accurately specify the amount of ideal contact ratio between the implant surface and the bone, thus various methods have been proposed to evaluate the degree of osseointegration.…”

Section: Introductionmentioning

confidence: 75%

Histological analysis of explanted implant-bone interface: a case report

Kim

Kang

Cho

et al. 2019

J Dent Rehabil Appl Sci

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Osseointegration has been reported to be a dynamic process in which the alveolar bone comes in direct contact with the implant. Various methods were tried to evaluate degree of osseointegration and the measurement of bone-implant contact (BIC) have been commonly used among them. To properly assess the BIC, only histologic analysis is available. However, few studies evaluated BIC of successfully osseointegrated implants in humans. Thus, this is a unique opportunity when implants should be explanted due to inappropriate positioning of implant, presence of pain or sensory disturbance, or broken screw or fixture. This report presents a case of the implant underwent 3-year functional load and a histologic analysis after the fixture fracture. The histomorphometric analysis revealed 53.1% of BIC measured along the whole implant and 70.9% measured only in subcrestal area, respectively. In the present study, although the implant was fractured, a high degree of BIC was observed.

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“…It is clear that the early healing period immediately following implant placement is a delicate moment and therefore important to be investigated, as this can determine the success of the rehabilitation. However, an evaluation of osseointegration in the long-term can be extremely interesting because it can clarify much about the relationship that develops between the implant surface and human bone over time [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Histological Evidence of the Osseointegration of Fractured Direct Metal Laser Sintering Implants Retrieved after 5 Years of Function

Mangano¹,

Mangano

Piattelli

et al. 2017

BioMed Research International

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Background. Direct metal laser sintering (DMLS) is an additive manufacturing technique that allows the fabrication of dental implants layer by layer through the laser fusion of titanium microparticles. The surface of DMLS implants is characterized by a high open porosity with interconnected pores of different sizes; therefore, it has the potential to enhance and accelerate bone healing. To date, however, there are no histologic/histomorphometric studies in the literature evaluating the interface between bone and DMLS implants in the long-term. Purpose. To evaluate the interface between bone and DMLS implants retrieved after 5 years of functional loading. Methods. Two fractured DMLS implants were retrieved from the human jaws, using a 5 mm trephine bur. Both the implants were clinically stable and functioned regularly before fracture. The specimens were processed for histologic/histomorphometric evaluation; the bone-to-implant contact (BIC%) was calculated. Results. Compact, mature lamellar bone was found over most of the DMLS implants in close contact with the implant surface; the histomorphometric evaluation showed a mean BIC% of 66.1% (±4.5%). Conclusions. The present histologic/histomorphometric study showed that DMLS implants were well integrated in bone, after 5 years of loading, with the peri-implant bone undergoing continuous remodeling at the interface.

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Periimplant Bone Response in Human-Retrieved, Clinically Stable, Successful, and Functioning Dental Implants After a Long-Term Loading Period

Abstract: All implants appeared to be well integrated in the surrounding mineralized bone, and all of them showed adequate bone-to-implant contact percentages.

Cited by 17 publications

References 25 publications

Immediate and delayed loading of fixed dental prostheses supported by single or two splinted implants: A histomorphometric study in dogs

Immediate and delayed loading of fixed dental prostheses supported by single or two splinted implants: A histomorphometric study in dogs

Histological analysis of explanted implant-bone interface: a case report

Histological Evidence of the Osseointegration of Fractured Direct Metal Laser Sintering Implants Retrieved after 5 Years of Function

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