Perigraft inflammation due to Dacron-covered stent-grafts in sheep iliac arteries: correlation of MR imaging and histopathologic findings.

Abstract

In sheep, MR imaging findings of perigraft soft-tissue edema and contrast enhancement correlated well with histopathologic findings of severe perigraft inflammation due to heparin-coated Dacron-covered stent-grafts.

Tracheal Replacement with Fresh and Cryopreserved Aortic Allograft in Adult Dog

“…In one of these studies, Dacron-covered stent grafts were applied to the iliac artery in sheep; contrast-enhanced MRI revealed an increased signal and, histologically, the infiltration of inflammatory cells was evident [22]. In this study, the reason for highly enhanced graft area at 1 mo may have been tissue reaction after surgery or an inflammatory response associated with allograft reaction.…”

“…Several studies have utilized contrast-MRI to assess arterial inflammation [22][23][24]. In one of these studies, Dacron-covered stent grafts were applied to the iliac artery in sheep; contrast-enhanced MRI revealed an increased signal and, histologically, the infiltration of inflammatory cells was evident [22].…”

Inflammatory Abdominal Aortic Aneurysm Endovascular Repair into the Long-Term Follow-Up

“…Comparisons cannot be made regarding the various types of stents used given the insufficient available data. Experimental studies 29,30 have reported that the endograft fabric may induce a graft versus host reaction, subsequently worsening the pre-existing inflammatory response, and Barret et al 27 suggested that a graft versus host reaction may be associated with PAF persistence. In this series, despite the use of varying materials, such as polytetrafluoroethylene (PTFE, n ¼ 4) and Dacron (n ¼ 5), encouraging results were found for inflammation.…”

Inflammatory Response to Polymeric Materials

“…In their study on stents made of Dacron-covered nitinol, Hayoz et al (1997) found nonspecific inflammatory reactions in some patients and an in vitro activation of neutrophils by the intact stent graft itself, but no activation by both Dacron and nitinol. In another study on Dacron-covered and heparin-coated Dacron-covered stent grafts implanted in sheep, Schurmann et al (1997) found a severe inflammatory response to the heparinized material, a moderate response to the Dacron-covered stent, and almost no response to noncovered ones.…”