2017
DOI: 10.1016/j.stem.2016.12.006
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Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo

Abstract: Summary Pericytes are widely believed to function as mesenchymal stem cells (MSCs) -multipotent tissue-resident progenitors with great potential for regenerative medicine. Cultured pericytes isolated from distinct tissues can differentiate into multiple cell types in vitro, or following transplantation in vivo. However, the cell fate plasticity of endogenous pericytes in vivo remains unclear. Here, we show that the transcription factor Tbx18 selectively marks pericytes and vascular smooth muscle cells in multi… Show more

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Cited by 398 publications
(359 citation statements)
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“…Interestingly, pericytes have also been hypothesized to be mesenchymal stem cells in adult tissue (4), however, recent studies using lineage tracing have disproved this theory (5). The current understanding of the role pericytes and their mesenchymal precursors play in adult lung disease, de novo angiogenesis, and vascular remodeling is controversial, as conflicting evidence depicts angiogenesis as both reparative and pathologic (6)(7)(8).…”
Section: Introductionmentioning
confidence: 99%
“…Interestingly, pericytes have also been hypothesized to be mesenchymal stem cells in adult tissue (4), however, recent studies using lineage tracing have disproved this theory (5). The current understanding of the role pericytes and their mesenchymal precursors play in adult lung disease, de novo angiogenesis, and vascular remodeling is controversial, as conflicting evidence depicts angiogenesis as both reparative and pathologic (6)(7)(8).…”
Section: Introductionmentioning
confidence: 99%
“…Pericytes have been traced in vivo in different tissues and found to retain their original identity [6,7]. It remains unclear, however, how long and exactly through what mechanisms these pericytes stimulate a host response.…”
mentioning
confidence: 99%
“…Both saphenous vein–derived swine cells and hAPCs were negative for the endothelial markers CD31 and VE‐cadherin, and expressed very low levels of CD146, whereas human umbilical vein endothelial cells and sPAECs (positive controls) express all the above antigens (Figure 5E). We also verify the expression of the T‐box family transcription factor Tbx18, which is reportedly selectively expressed by microvascular pericytes and vascular smooth muscle cells in the adult mouse 27. Results confirm that the TBX18 gene is detected by polymerase chain reaction for both cell lines (Ct value hAPCs=24.4 and Ct value sAPCs=26.6, data not shown), with the expression being confirmed at the protein level by Western blot analyses of cell lysates (Figure 5F).…”
Section: Resultsmentioning
confidence: 71%