Pericytes in the Gut

Ramirez, Marta; Pell, Núria; Mejías, Marc; Fernández, Mercedes

doi:10.1007/978-3-030-11093-2_5

Cited by 8 publications

(3 citation statements)

References 69 publications

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“…The expression of pericytes, which regulate endothelial cells, was significantly reduced in the saline and LC-H 2 S lipo treated groups compared to the normal group (P < 0.01 and P < 0.01, respectively). However, the expression of pericytes was not significantly different in the ST-H 2 S lipo treated group compared to the normal group (P = 0.424), indicating that the vasculature in the colon was successfully restored in the group 42 (Figure 10E, F).…”

Section: Transcriptomics-level Analysis Of Immunomodulatory Process B...mentioning

confidence: 94%

Development of Spleen Targeting H₂S Donor Loaded Liposome for the Effective Systemic Immunomodulation and Treatment of Inflammatory Bowel Disease

Lee

Park

et al. 2023

ACS Nano

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Nanoparticles are primarily taken up by immune cells after systemic administration. Thus, they are considered an ideal drug delivery vehicle for immunomodulation. Because the spleen is the largest lymphatic organ and regulates the systemic immune system, there have been studies to develop spleen targeting nanoparticles for immunomodulation of cancer and immunological disorders. Inflammatory bowel disease (IBD) includes disorders involving chronic inflammation in the gastrointestinal tract and is considered incurable despite a variety of treatment options. Hydrogen sulfide (H 2 S) is one of the gasotransmitters that carries out anti-inflammatory functions and has shown promising immunomodulatory effects in various inflammatory diseases including IBD. Herein, we developed a delicately tuned H 2 S donor delivering liposome for spleen targeting (ST-H 2 S lipo) and studied its therapeutic effects in a dextran sulfate sodium (DSS) induced colitis model. We identified the ideal PEG type and ratio of liposome for a high stability, loading efficiency, and spleen targeting effect. In the treatment of the DSS-induced colitis model, we found that ST-H 2 S lipo and conventional long-circulating liposomes loaded with H 2 S donors (LC-H 2 S lipo) reduced the severity of colitis, whereas unloaded H 2 S donors did not. Furthermore, the therapeutic effect of ST-H 2 S lipo was superior to that of LC-H 2 S lipo due to its better systemic immunomodulatory effect than that of LC-H 2 S lipo. Our findings demonstrate that spleen targeting H 2 S lipo may have therapeutic potential for IBD.

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Section: Transcriptomics-level Analysis Of Immunomodulatory Process B...mentioning

confidence: 94%

Development of Spleen Targeting H₂S Donor Loaded Liposome for the Effective Systemic Immunomodulation and Treatment of Inflammatory Bowel Disease

Lee

Park

et al. 2023

ACS Nano

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“…Pericytes can also differentiate into myofibroblasts under inflammatory conditions. Pericytes are contractile cells of mesenchymal origin that are normally present in the walls of both normal and microvessels; they also have a close association with the endothelium [13].…”

Section: Myofibroblastmentioning

confidence: 99%

Fibroblast the Non-Professional Immune Cell

Reaves¹

2022

AJBSR

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“…As one representative of mesenchymal stromal cell, colonic mesenchymal stromal cells reside underneath the colonic epithelium, covering lamina propria, submucosa, muscularis mucosae, muscularis propria, serosa and mesothelium. Those cells include telocytes ( 8 ), CD34 + fibroblasts ( 10 ), pericytes ( 11 ), Map3k2-Regulated Intestinal Stromal Cells (MRISCs) ( 12 ), myocytes ( 13 ), interstitial cell of cajal ( 14 ) and mesothelial cells ( 15 ). They are negative for hematopoietic lineage gene PTPRC (CD45), epithelial lineage gene EPCAM or CDH1 (E-Cadherin), endothelial lineage gene PECAM1 (CD31).…”

Section: Introductionmentioning

confidence: 99%

Immune niches orchestrated by intestinal mesenchymal stromal cells lining the crypt-villus

et al. 2022

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The mammalian intestine is an organ that can be spatially defined by two axes: longitudinal and vertical. Such anatomical structure ensures the maintenance of a relatively immuno-quiescent and proliferation-promoting crypt for intestinal stem cell differentiation while actively warding off the invading intestinal microbes at the villus tip during digestion and nutrient absorption. Such behavior is achieved by the fine coordination among intestinal epithelial cells, intestinal mesenchymal stromal cells and tissue-resident immune cells like myeloid cells and lymphocytes. Among these cell types resided in the colon, intestinal mesenchymal stromal cells are considered to be the essential link between epithelium, vasculature, neuronal system, and hematopoietic compartment. Recent advancement of single cell and spatial transcriptomics has enabled us to characterize the spatial and functional heterogeneity of intestinal mesenchymal stromal cells. These studies reveal distinctive intestinal mesenchymal stromal cells localized in different regions of the intestine with diverse functions including but not limited to providing cytokines and growth factors essential for different immune cells and epithelial cells which predict niche formation for immune function from the villus tip to the crypt bottom. In this review, we aim to provide an overall view of the heterogeneity of intestinal mesenchymal stromal cells, the spatial distribution of these cells along with their interaction with immune cells and the potential regulatory cytokine profile of these cell types. Summarization of such information may enrich our current understanding of the immuno-regulatory functions of the newly identified mesenchymal stromal cell subsets beyond their epithelial regulatory function.

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Pericytes in the Gut

Cited by 8 publications

References 69 publications

Development of Spleen Targeting H₂S Donor Loaded Liposome for the Effective Systemic Immunomodulation and Treatment of Inflammatory Bowel Disease

Development of Spleen Targeting H₂S Donor Loaded Liposome for the Effective Systemic Immunomodulation and Treatment of Inflammatory Bowel Disease

Fibroblast the Non-Professional Immune Cell

Immune niches orchestrated by intestinal mesenchymal stromal cells lining the crypt-villus

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Pericytes in the Gut

Cited by 8 publications

References 69 publications

Development of Spleen Targeting H2S Donor Loaded Liposome for the Effective Systemic Immunomodulation and Treatment of Inflammatory Bowel Disease

Development of Spleen Targeting H2S Donor Loaded Liposome for the Effective Systemic Immunomodulation and Treatment of Inflammatory Bowel Disease

Fibroblast the Non-Professional Immune Cell

Immune niches orchestrated by intestinal mesenchymal stromal cells lining the crypt-villus

Contact Info

Product

Resources

About

Development of Spleen Targeting H₂S Donor Loaded Liposome for the Effective Systemic Immunomodulation and Treatment of Inflammatory Bowel Disease

Development of Spleen Targeting H₂S Donor Loaded Liposome for the Effective Systemic Immunomodulation and Treatment of Inflammatory Bowel Disease