Pericyte-targeting drug delivery and tissue engineering

Kang, Eung Shick; Shin, Jong Wook

doi:10.2147/ijn.s105274

Cited by 25 publications

(11 citation statements)

References 56 publications

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“…One recent study demonstrated successful peptide-conjugated nanoparticle delivery of the anticancer drug docetaxel to peripheral pericytes in rats with neuroblastoma (Guan et al, 2014), while peptide-conjugated liposomal nanoparticles have also been used to effectively target pericytes and deliver the anticancer drug doxorubicin in mice with lung melanoma (Loi et al, 2010). Nanoparticle formulation with pericyte-binding peptide sequences is possible (Kang and Shin, 2016) but it has not yet been trialed in the brain. The delivery of pericyte-targeted drugs through nanoparticles could provide a novel therapeutic avenue for the treatment of many neurovascular diseases.…”

Section: Future Directionsmentioning

confidence: 99%

Pericytes and Neurovascular Function in the Healthy and Diseased Brain

Brown

Foster

Courtney

et al. 2019

Front. Cell. Neurosci.

292

205

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Pericytes are multi-functional cells embedded within the walls of capillaries throughout the body, including the brain. Pericytes were first identified in the 1870s, but little attention was paid to them during the following century. More recently, numerous vascular functions of pericytes have been identified including regulation of cerebral blood flow, maintenance of the blood-brain barrier (BBB), and control of vascular development and angiogenesis. Pericytes can also facilitate neuroinflammatory processes and possess stem cell-like properties. Pericytes form part of the neurovascular unit (NVU), a collection of cells that control interactions between neurons and the cerebral vasculature to meet the energy demands of the brain. Pericyte structure, expression profile, and function in the brain differ depending on their location along the vascular bed. Until recently, it has been difficult to accurately define the sub-types of pericytes, or to specifically target pericytes with pharmaceutical agents, but emerging techniques both in vitro and in vivo will improve investigation of pericytes and allow for the identification of their possible roles in diseases. Pericyte dysfunction is increasingly recognized as a contributor to the progression of vascular diseases such as stroke and neurodegenerative diseases such as Alzheimer’s disease. The therapeutic potential of pericytes to repair cerebral blood vessels and promote angiogenesis due to their ability to behave like stem cells has recently been brought to light. Here, we review the history of pericyte research, the present techniques used to study pericytes in the brain, and current research advancements to characterize and therapeutically target pericytes in the future.

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Section: Future Directionsmentioning

confidence: 99%

Pericytes and Neurovascular Function in the Healthy and Diseased Brain

Brown

Foster

Courtney

et al. 2019

Front. Cell. Neurosci.

292

205

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“…Literature cites that they strengthen the blood vessel barrier in co-ordination with endothelial cells or other blood components, thereby preventing vascular leakage. Besides this, they are also known as metastatic stimulators and contribute in accumulation of cancer stem cells within tumor microenvironment (Gerhardt and Betsholtz, 2003 ; Kang and Shin, 2016 ; Ferland-McCollough et al, 2017 ).…”

Section: Understanding the Challenges And Opportunities Presented By mentioning

confidence: 99%

Tumor Microenvironment Targeted Nanotherapy

2018

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Recent developments in nanotechnology have brought new approaches to cancer diagnosis and therapy. While enhanced permeability and retention effect promotes nano-chemotherapeutics extravasation, the abnormal tumor vasculature, high interstitial pressure and dense stroma structure limit homogeneous intratumoral distribution of nano-chemotherapeutics and compromise their imaging and therapeutic effect. Moreover, heterogeneous distribution of nano-chemotherapeutics in non-tumor-stroma cells damages the non-tumor cells, and interferes with tumor-stroma crosstalk. This can lead not only to inhibition of tumor progression, but can also paradoxically induce acquired resistance and facilitate tumor cell proliferation and metastasis. Overall, the tumor microenvironment plays a vital role in regulating nano-chemotherapeutics distribution and their biological effects. In this review, the barriers in tumor microenvironment, its consequential effects on nano-chemotherapeutics, considerations to improve nano-chemotherapeutics delivery and combinatory strategies to overcome acquired resistance induced by tumor microenvironment have been summarized. The various strategies viz., nanotechnology based approach as well as ligand-mediated, redox-responsive, and enzyme-mediated based combinatorial nanoapproaches have been discussed in this review.

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“…Targeting pericytes through nanotechnology could become a novel treatment strategy for stroke, and this is made possible through the formulation of nanoparticles with pericyte-binding peptide sequences. 164 However, these pericyte-targeting nanoparticles have yet to be trialed in the brain.…”

Section: Other Areas Of Interest For Strokementioning

confidence: 99%

Applications of Nanotechnology in the Diagnosis and Therapy of Stroke

Landowski

Niego

Sutherland

et al. 2019

Semin Thromb Hemost

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Stroke is a leading cause of death and disability worldwide. The classification of stroke subtypes is difficult but critical for the prediction of clinical course and patient management, and limited treatment options are available. There is an urgent need for improvements in both diagnosis and therapy. Strokes have rapidly evolving phases of damage involving unique compartments of the brain, which imposes severe limitations for current diagnostic and treatment procedures. The rapid development of nanotechnology in other areas of modern medicine has ignited a widespread interest in its potential for the field of stroke. An important feature of nanoparticles is the relative ease in which their structures and surface chemistries can be modified for specific and potentially multiple, simultaneous purposes. Nanoparticles can be synthesized to carry and deliver therapeutics to specific cellular or subcellular compartments; they can be engineered to provide enhanced contrast for imaging based on the detection of changes in the blood flow; or possess ligand-specific chemistries which can facilitate diagnosis and monitor the treatment response. More specifically for a stroke, nanoparticles can be engineered to release their payload in response to the distinct extracellular processes occurring around the clot and in the ischemic penumbra, as well as aid in the detection of pathological hallmarks present at various stages of stroke progression. These capacities allow targeted release of disease-modifying agents in the affected brain tissue, increasing treatment efficacy, and limiting unwanted side effects. While nanospheres, liposomes, and mesoporous nanostructures all emerge as future prospects for stroke treatment and diagnosis, much of this potential is yet to be clinically realized. This review outlines aspects of nanotechnology identified as having potential to revolutionize the field of stroke.

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Pericyte-targeting drug delivery and tissue engineering

Cited by 25 publications

References 56 publications

Pericytes and Neurovascular Function in the Healthy and Diseased Brain

Pericytes and Neurovascular Function in the Healthy and Diseased Brain

Tumor Microenvironment Targeted Nanotherapy

Applications of Nanotechnology in the Diagnosis and Therapy of Stroke

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