2015
DOI: 10.1002/bdra.23381
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Periconceptional changes in weight and risk of delivering offspring with conotruncal heart defects

Abstract: Given current recommendations about limited weight gain for obese pregnant women, these data indicate that dieting may not substantially increase a fetus' risk of having a conotruncal defect.

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“…respiratory distress (n = 1048) 32 ; neonatal seizures (n = 1071) 78 ; meconium aspiration (n = 757) 77 ; neonatal, postneonatal, and infant mortality (n = 515,252) 68 ; infant anthropometrics (n = 73) 45 ; perinatal death (n = 24,795) 43 ; a composite measure of congenital anomalies (n = 45,439) 26,43 ; spina bifida (n = 5060) 79 ; conotruncal heart defects (n = 1685) 80 ; gastroschisis (n = 5343) 81 ; and cleft lip (n = 220,328). 82 For neonatal outcomes, an interpregnancy gain or loss of ≥1 BMI unit appears to be associated with an increased risk for spina bifida, 79 gastroschisis, 81 and respiratory distress 32 compared with stable weight.…”
Section: Narrative Synthesismentioning
confidence: 99%
“…respiratory distress (n = 1048) 32 ; neonatal seizures (n = 1071) 78 ; meconium aspiration (n = 757) 77 ; neonatal, postneonatal, and infant mortality (n = 515,252) 68 ; infant anthropometrics (n = 73) 45 ; perinatal death (n = 24,795) 43 ; a composite measure of congenital anomalies (n = 45,439) 26,43 ; spina bifida (n = 5060) 79 ; conotruncal heart defects (n = 1685) 80 ; gastroschisis (n = 5343) 81 ; and cleft lip (n = 220,328). 82 For neonatal outcomes, an interpregnancy gain or loss of ≥1 BMI unit appears to be associated with an increased risk for spina bifida, 79 gastroschisis, 81 and respiratory distress 32 compared with stable weight.…”
Section: Narrative Synthesismentioning
confidence: 99%