Pericarditis Caused by Actinobacillus actinomycetemcomitans

Horowitz, Edward A.; Pugsley, Mary P.; Turbes, Paul G.; Clark, Richard B.

doi:10.1093/infdis/155.1.152

Cited by 23 publications

(6 citation statements)

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“…In contrast, a study in a Japanese population reported that less than 10% of the chronic periodontitis diseased site was positive for A. actinomycetemcomitans [33]. Furthermore, this microorganism has been isolated from several other non-oral infections, including endocarditis [34] and pericarditis [35]. Recently, these species were identified in atheromatous plaques of cardiovascular disease patients [36], suggesting a possible role for P. gingivalis and A. actinomycetemcomitans in the development of this lesion.…”

Section: Discussionmentioning

confidence: 99%

High incidence of Aggregatibacter actinomycetemcomitansinfection in patients with cerebral infarction and diabetic renal failure: a cross-sectional study

et al. 2013

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BackgroundRecent epidemiological studies suggest that periodontitis is a major risk factor for renal failure and cerebral infarction. The aim of this study was to evaluate the association among periodontitis, renal failure, and cerebral infarction, focusing on microbiological and immunological features.MethodsTwenty-one patients treated with hemodialysis (HD) were enrolled in this study. They were 8 with diabetic nephropathy and 13 with non-diabetic nephropathy. Blood examination, periodontal examination, brain magnetic resonance image (MRI), and dental radiography were performed on all patients. Subgingival plaque, saliva, and blood samples were analyzed for the periodontal pathogens, Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Porphyromonas gingivalis (P. gingivalis), and Prevotella intermedia (P. intermedia) using quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA).ResultsWe found that the patients with diabetic nephropathy had more A. actinomycetemcomitans compared with non-diabetic nephropathy (P = 0.038) in dental plaque. Furthermore, the patients with diabetic nephropathy showed a significantly higher incidence of cerebral infarction compared with those with non-diabetic nephropathy (P = 0.029). Clinical oral and radiographic scores tended to be higher among patients in the diabetic nephropathy group than in the non-diabetic nephropathy group.ConclusionsPeriodontal pathogens, particularly A. actinomycetemcomitans, may play a role, at least a part, in the development of cerebral infarction in Japanese HD patients with diabetic nephropathy.

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Section: Discussionmentioning

confidence: 99%

High incidence of Aggregatibacter actinomycetemcomitansinfection in patients with cerebral infarction and diabetic renal failure: a cross-sectional study

et al. 2013

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“…17,18) It also contributes to chronic periodontitis. 19,20) Furthermore, this microorganism has been isolated from several other nonoral infections, including brain abscess, 21) endocarditis, 22) pericarditis, 23) pneumonia, 24) and septicemia. 25,26) Recently, Desvarieux, et al found the cumulative periodontal pathogenic burden (A. actinomycetemcomitans, P. gingivalis, T. denticola, and T. forsythensis) was significantly related with carotid artery intimae thickness.…”

Section: Discussionmentioning

confidence: 99%

High Incidence of Actinobacillus Actinomycetemcomitans Infection in Acute Coronary Syndrome

et al. 2007

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SUMMARYRecent epidemiological studies suggest that periodontitis is an important risk factor for coronary heart disease (CHD). The aim of this study was to evaluate the association between periodontitis and CHD, particularly acute coronary syndrome (ACS), focusing on microbiological and immunological features.Twenty-eight CHD patients, 15 with ACS and 13 with chronic CHD, were included in this study. Coronary angiography, periodontal examination, and dental radiography were performed in all patients. Subgingival plaque, saliva, and blood samples were analyzed for the periodontopathogens Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythensis, Treponema denticola, and Prevotella intermedia using polymerase chain reaction.Specific serum antibody titers to the 5 periodontal pathogens were determined by enzyme-linked immunosorbent assay. It was found that 33% of the ACS patients (5/15) harbored A. actinomycetemcomitans in oral samples, whereas no A. actinomycetemcomitans (0/13) was found in the chronic CHD patients (P < 0.05). Furthermore, ACS patients showed significantly higher serum IgG titers to A. actinomycetemcomitans (P < 0.05) compared with chronic CHD. More tooth loss and alveolar bone loss were noted in ACS patients than in chronic CHD patients, although the differences were not statistically significant.Periodontal pathogens, particularly A. actinomycetemcomitans, may play a role in the development of ACS. (Int Heart J 2007; 48: 663-675)

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“…1,2,9,10 In addition, A. actinomycetemcomitans has been reported to be a causative agent of various infectious diseases, such as endocarditis, pericarditis, meningitis, osteomyelitis, and subcutaneous abscess. [11][12][13][14][15] Most A. actinomycetemcomitans strains isolated from periodontally diseased sites produce a 115 kDa heat-labile protein that specifically lyses human polymorphonuclear leukocytes (PMN) and macrophages. [16][17][18][19] A. actin-omycetemcomitans leukotoxin belongs to the repeatsin-toxin (RTX) family of Gram-negative bacterial cytolysins which includes the alpha-hemolysin of Escherichia coli and the leukotoxin of Pasteurella haemolytica.…”

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confidence: 99%

A Novel Insertion Sequence Increases the Expression of Leukotoxicity in Actinobacillus actinomycetemcomitans Clinical Isolates

Nishihara

Demuth

et al. 1999

Journal of Periodontology

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Pericarditis Caused by Actinobacillus actinomycetemcomitans

Cited by 23 publications

References 0 publications

High incidence of Aggregatibacter actinomycetemcomitansinfection in patients with cerebral infarction and diabetic renal failure: a cross-sectional study

High incidence of Aggregatibacter actinomycetemcomitansinfection in patients with cerebral infarction and diabetic renal failure: a cross-sectional study

High Incidence of Actinobacillus Actinomycetemcomitans Infection in Acute Coronary Syndrome

A Novel Insertion Sequence Increases the Expression of Leukotoxicity in Actinobacillus actinomycetemcomitans Clinical Isolates

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