Pericarditis-associated atrial fibrillation

Mayosi, Bongani M.

doi:10.1136/heartjnl-2015-307917

Cited by 9 publications

(8 citation statements)

References 10 publications

(18 reference statements)

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“…Earlier studies have focused on factors associated with the development of effusions in general, including in the early postoperative period during the index admission, rather than factors associated with readmissions 18,20 . Furthermore, predicting readmissions due to pericardial effusions might also be difficult, as the risk of atrial fibrillation increases as a subsequent consequence of pericardial effusions 21 . Thus, symptoms and the following readmission might be caused by, or diagnosed as, atrial fibrillation and not due to pericardial effusion.…”

Section: Discussionmentioning

confidence: 99%

“…Permanent pacemaker, n (%) 6 (2) [18][19][20] Earlier studies have focused on factors associated with the development of effusions in general, including in the early postoperative period during the index admission, rather than factors associated with readmissions. 18,20 Furthermore, predicting readmissions due to pericardial effusions might also be difficult, as the risk of atrial fibrillation increases as a Mechanical aortic valve 52 (21) 100 (14) .010* 15 (13) 85 (14) .768…”

Section: Preoperative Informationmentioning

confidence: 99%

“…subsequent consequence of pericardial effusions. 21 Thus, symptoms and the following readmission might be caused by, or diagnosed as, atrial fibrillation and not due to pericardial effusion. The rates of pleural-and pericardial effusions correspond with earlier studies, 22,23 similarly, rates of thoracentesis have been reported up to 43%.…”

Section: Preoperative Informationmentioning

confidence: 99%

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Causes and characteristics associated with early and late readmission after open‐heart valve surgery

et al. 2020

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Objectives The objectives of the study were to describe the causes of readmission from discharge to 30 days and from day 31 to 180 after discharge and to investigate the characteristics associated with overall and cause‐specific readmissions after open‐heart valve surgery. Methods A single‐center, retrospective cohort of 980 patients undergoing open‐heart valve surgery from 2013 to 2016. Time to the first readmission was analyzed using univariable and multivariable Cox proportional hazard models. Results are reported as hazard ratios (HR) with 95% confidence intervals (CI). Results In total, 366 patients (37%) experienced unplanned cardiac readmission within 180 days after discharge. Within 30 days after discharge, the most frequent causes of readmission were pericardial/pleural effusions (n = 87), infections (n = 50), and atrial fibrillation/flutter (n = 45). Accordingly, infections (n = 32) were the most common cause from day 31 to 180. No powerful predictors of overall cardiac readmission were identified, but several characteristics were associated with cause‐specific readmissions: age ≤65 years (HR: 1.85; CI: 1.18‐2.88), male gender (HR: 1.85; CI: 1.11‐3.09), high alcohol intake (HR: 1.99; CI: 1.22‐3.24) and mitral valve procedures (HR: 1.86; CI: 1.11‐3.10) were associated with readmissions due to effusions. Ischemic heart disease with a prior percutaneous coronary intervention (HR: 2.94; CI: 1.53‐5.63), mitral valve procedures (HR: 2.10; CI: 1.23‐3.59), and postoperative atrial fibrillation/flutter (HR: 1.71; CI: 1.03‐2.85) were associated with atrial fibrillation/flutter readmissions. Conclusion Predicting overall readmissions after open‐heart valve surgery is difficult as causes of readmissions vary and different causes are associated with different characteristics. Future studies should target reducing cause‐specific readmissions.

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Section: Discussionmentioning

confidence: 99%

Section: Preoperative Informationmentioning

confidence: 99%

Section: Preoperative Informationmentioning

confidence: 99%

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Causes and characteristics associated with early and late readmission after open‐heart valve surgery

et al. 2020

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“…Inflammatory conditions, such as pericarditis or myocarditis, are associated with AF 104,105 . A recent study regarding CD45 + and CD3 + cell infiltrates in the atria from patients with AF indicated that inflammatory cell infiltrates were significantly higher in patients with paroxysmal or non‐paroxysmal AF, being greater in the adipose tissue rather than in the myocardium.…”

Section: Pathophysiological Mechanisms Of Af Related To Eatmentioning

confidence: 99%

Updates on epicardial adipose tissue mechanisms on atrial fibrillation

et al. 2021

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Summary Obesity is a well‐known risk factor for atrial fibrillation (AF). Local epi‐myocardial or intra‐myocardial adiposity caused by aging, obesity, or cardiovascular disease (CVD) is considered to be a better predictor of the risk of AF than general adiposity. Some of the described mechanisms suggest that epicardial adipose tissue (EAT) participates in structural remodeling owing to its endocrine activity or its infiltration between cardiomyocytes. Epicardial fat also wraps up the ganglionated plexi that reach the myocardium. Although the increment of volume/thickness and activity of EAT might modify autonomic activity, autonomic system dysfunction might also change the endocrine activity of epicardial fat in a feedback response. As a result, new preventive therapeutic strategies are focused on reducing adiposity and weight loss before AF ablation or inhibiting autonomic neurotransmitter secretion on fat pads during open‐heart surgery to reduce the recurrence or postoperative risk of AF. In this manuscript, we review some of the novel findings regarding the pathophysiology and associated risk factors of AF, with special emphasis on the role of EAT in the electrical, structural, and molecular mechanisms of AF initiation and maintenance. In addition, we have included a brief note provided on epicardial fat preclinical models that could be useful for identifying new therapeutic targets.

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“…In a Greek-Italian prospective study on acute pericarditis, 35 (4.3%) of 822 patients had AF or flutter within 24 hours of the onset of acute pericarditis that resolved within 24 hours in 74.3% of cases, but recurred in one-third of patients in association with recurrent pericarditis over a 30-month follow-up period (75% within 3 months). 15…”

mentioning

confidence: 99%