Pericardial mesothelioma in a dog: long‐term survival after pericardiectomy in combination with chemotherapy

Closa, Josep Maria; Font, Albert; Mascort, Juanjo

doi:10.1111/j.1748-5827.1999.tb03105.x

Cited by 46 publications

(27 citation statements)

References 7 publications

(1 reference statement)

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“…16 Difficulty of diagnosis of mesothelioma in dogs is attributed to clinical signs related to cavitary effusions rather than development of a discrete mass. 7 The presenting clinical signs, physical examination findings, and results of noninvasive diagnostic testing in the Amazon parrot reported here were consistent with those of birds and dogs with both neoplastic and nonneoplastic pericardial effusion. Clinical signs are usually vague and may include lethargy, inappetence, weight loss, weakness, and exercise intolerance.…”

Section: Discussionsupporting

confidence: 74%

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Pericardial Mesothelioma in a Yellow-naped Amazon Parrot (Amazona auropalliata)

McCleery¹,

Jones²,

Manasse³

et al. 2015

Journal of Avian Medicine and Surgery

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A 37-year-old female yellow-naped Amazon parrot (Amazona auropalliata) was presented with a history of lethargy, inappetence, and decreased vocalizations. On examination, the coelom was moderately distended and palpated fluctuant, and the heart was muffled on auscultation. Coelomic ultrasound, coelomocentesis, and radiographs were performed and revealed an enlarged cardiac silhouette and marked coelomic effusion. Pericardial effusion was confirmed by echocardiography. A well-circumscribed, hyperechoic soft tissue density was observed at the level of the right atrium on initial echocardiography; however, a cardiac mass was not identified by computed tomography scan or repeat echocardiograms. Ultrasound-guided pericardiocentesis was performed under anesthesia, and cytology results were consistent with hemorrhage; no neoplastic cells were identified. A repeat echocardiogram 4 days after pericardiocentesis revealed recurrence of the pericardial effusion. Due to the grave prognosis, the owners declined endoscopic pericardiectomy, and the patient died the following day. On postmortem examination, the pericardial surface of the heart was covered in a white to yellow, multinodular mass layer. Histologic analysis revealed a multinodular mass extending from the atria, running along the epicardium distally, and often extending into the myocardium. Neoplastic cells present in the heart mass and pericardium did not stain with a Churukian-Schenk stain, and thyroglobulin immunohistochemistry was negative. Cytokeratin and vimentin stains showed positive expression in the neoplastic cells within the mass. These results are consistent with a diagnosis of mesothelioma. This is the first report of mesothelioma in a psittacine bird.

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Section: Discussionsupporting

confidence: 74%

“…7,8 Tumor spread is typically through invasion of contiguous tissue, and distant metastasis is rare. 9 Asbestos exposure has been linked to the development of mesothelioma in both humans and dogs.…”

Section: Discussionmentioning

confidence: 99%

Pericardial Mesothelioma in a Yellow-naped Amazon Parrot (Amazona auropalliata)

McCleery¹,

Jones²,

Manasse³

et al. 2015

Journal of Avian Medicine and Surgery

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“…Although most studies described that canine mesotheliomas have been seen with both pleural and pericardial effusion [2,4,5,7,8], in our case we did not determine any evidence of pericardial effusion and even effusion in abdominal cavity.…”

Section: Discussioncontrasting

confidence: 86%

“…Fluid accumulation is the major sign [6]. Many studies has been described that the complete blood count was normal [1,6,7] but in our case the patient has moderate leucocytosis. Compatible with our case remarkable leucocytosis (30.5  10 9 /L) was also found in a six year old male crossbred dog with pericardial mesothelioma.…”

Section: Discussionmentioning

confidence: 45%

Pleural Effusion in a Dog with Mesothelioma

Ülgen¹,

Bakırel²,

KutayYıldız³

et al. 2015

JLS

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In this case; mesothelioma was likely diagnosed in 7 years old male mix breed dog which was brought to Veterinary Research and Teaching Hospital of Istanbul University with complaints of general weakness and severe dyspnea. The dog had been misdiagnosed with faryngitis and hernia diaphragmatica before it was brought to our faculty clinic. Apparent abdominal respiration was inspected and supressed heart sounds, abnormal respiratory sounds and pleural rub were detected by auscultation of thorax. Radiographic examination and blood analysis were performed. Chest X-ray examination demonstrates both sided pleural effusion. Leukocytosis (WBC = 36.2  10 3 µL) was detected on blood count. By thoracocentesis, 40 mL fluid was drained and cytologic examination was performed. Numerous pleomorphic, atypical, multinuclear or multinucleolar mesothelial cells were observed and cytologic findings were pretty compatible with mesothelioma. The dog died before medication and the owner of the dog didn't give the confirmation for necropsy. In our clinical case we did not confirm any contact of the dog with asbestos or larger amount of pesticides, which are described as etiological factors of mesothelioma. As mesothelioma is a very rare health condition for dogs, it might be lead up to misdiagnosis.

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“…Treatments with intracavitary platinum drugs have been reported in canine mesotheliomas [6,8,10,13]. Dogs treated with intrathoracic and intravenous cisplatin or intravenous doxorubicin remained free of disease for 27 months [2]. In another report, a dog survived for 300 days after a doxorubicin and intracavitary cisplatin treatment [15].…”

mentioning

confidence: 99%

Palliative Intravenous Cisplatin Treatment for Concurrent Peritoneal and Pleural Mesothelioma in a Dog

Seo

Choi

Jung

et al. 2007

The Journal of Veterinary Medical Science

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ABSTRACT. A 10-year-old Maltese dog was presented with abdominal distention and dyspnea. Cytological examination of pleural and peritoneal effusion was suggestive of malignant effusion of glandular origin. Numerous, multifocal, tan to white nodules were disseminated throughout the surface of the abdominal organs and peritoneum at biopsy. Histologically, the tumors were revealed to be an epithelial type of mesothelioma. Neoplastic cells co-expressed cytokeratin and vimentin. Intravenous administration of cisplatin was chosen as the treatment. During treatment, the dog's overall body condition improved and the clinical signs were relieved without significant side effects. The survival time from diagnosis to sudden death by unknown cause was 153 days.

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Pericardial mesothelioma in a dog: long‐term survival after pericardiectomy in combination with chemotherapy

Cited by 46 publications

References 7 publications

Pericardial Mesothelioma in a Yellow-naped Amazon Parrot (Amazona auropalliata)

Pericardial Mesothelioma in a Yellow-naped Amazon Parrot (Amazona auropalliata)

Pleural Effusion in a Dog with Mesothelioma

Palliative Intravenous Cisplatin Treatment for Concurrent Peritoneal and Pleural Mesothelioma in a Dog

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