Pericardial effusion associated with systemic inflammatory disease in seven dogs (January 2006 – January 2012)

Covey, Heather L.; Connolly, David

doi:10.1016/j.jvc.2017.11.002

Cited by 11 publications

(15 citation statements)

References 23 publications

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“…This reduction in myocardial function is generally reversible in humans, with echocardiographic changes resolving within 7 to 10 days after the episode of septic shock (Bulmer ). This was not always seen in this case series or in those reported by Covey & Connolly (). Although all patients in this study recovered clinically with anti‐inflammatory or immunosuppressive therapy, development of myocardial dysfunction has been shown to be a negative prognostic indicator in patients with sepsis and SIRS (Nelson & Thompson ).…”

Section: Discussioncontrasting

confidence: 51%

“…SRMA histologically causes fibrinoid arteritis which has been reported to affect the coronary vessels as well as meningeal vessels, resulting in altered vascular permeability that could potentially cause pericardial effusion (Tipold & Schatzberg ). However, the pericardial effusion noted in the two cases discussed by Covey & Connolly () which did not have SRMA suggests a secondary mechanism for the development of pericardial effusion, the most likely of which being inflammatory cytokine induced dysfunction in vascular permeability (Snyder et al . ).…”

Section: Discussionmentioning

confidence: 99%

“…In the Covey & Connolly () study, two other patients with inflammatory disease and pericardial effusion were described: one with pleural effusion and one with systemic inflammatory response syndrome (SIRS) of unknown aetiology. SRMA histologically causes fibrinoid arteritis which has been reported to affect the coronary vessels as well as meningeal vessels, resulting in altered vascular permeability that could potentially cause pericardial effusion (Tipold & Schatzberg ).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, further work is required to determine the extent and timing of cTnI increase that occurs with inflammatory conditions. A recent case series (Covey & Connolly 2018) documented cardiac changes in seven dogs with systemic inflammatory dis-eases, including five with SRMA. All dogs had mild pericardial effusion (not requiring pericardiocentesis) and all had increased cTnI, but none had spontaneous echocontrast.…”

Section: Discussionmentioning

confidence: 99%

“…Cardiac troponin I (cTnI) is extensively used as a marker of cardiac myocyte damage in dogs but has been shown to be non-specific, increasing in various cardiac and non-cardiac conditions (Langhorn & Willesen 2016). Left ventricular systolic dysfunction, pericardial effusion and increased cTnI have been reported in five dogs with SRMA (Covey & Connolly 2018). These patients did not show clinical signs of cardiac disease and their pericardial effusion resolved without therapeutic pericardiocentesis.…”

Section: Introductionmentioning

confidence: 99%

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The occurrence of cardiac abnormalities in canine steroid‐responsive meningitis arteritis

Spence

French

Penderis³

et al. 2019

J of Small Animal Practice

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Objectives To document the prevalence of cardiac abnormalities in dogs with steroid‐responsive meningitis arteritis and to assess resolution of these abnormalities following corticosteroid therapy. Materials and Methods Steroid‐responsive meningitis arteritis was diagnosed based on signalment, physical examination findings, complete blood count, biochemistry and CSF analysis. Echocardiography, C‐reactive protein and cardiac troponin I were measured in all cases before and 10 to 14 days after commencing corticosteroid therapy. Fibrinogen was also measured in a proportion of dogs. Results Fourteen dogs were prospectively enrolled. Increased cardiac troponin I was identified in five of 14 dogs and echocardiographic abnormalities were detected in 12 of 14 dogs, including spontaneous echo contrast (12 of 14), mild pericardial effusion (five of 14) and mildly decreased fractional shortening (five of 14). All dogs had increased C‐reactive protein and fibrinogen was increased in 11 of 12. Corticosteroid treatment was associated with clinical improvement and normalisation of C‐reactive protein in all dogs. The cardiac troponin I levels normalised in four of five and fibrinogen had normalised in all five dogs which were retested. Spontaneous echo contrast improved or completely resolved in 12 of 12 and pericardial effusion resolved in five of five dogs. Fractional shortening normalised in two of five dogs. Clinical Significance Cardiac changes are common in dogs with steroid‐responsive meningitis arteritis and most resolve with therapy. Further investigation into the cause and significance of these changes is necessary in determining whether antithrombotic therapy or positive inotropic therapy is indicated.

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Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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