Periarterial papaverine improves early postoperative renal function after retroperitoneoscopic partial nephrectomy

Marszalek, Martin; Meixl, H.; Pitzler, C.; Unger, Daniela; Rauchenwald, Michael; Jeschke, Klaus Nielsen; Madersbacher, Stephan

doi:10.1007/s00345-011-0712-1

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…The renal tumor was detected and several millimeters of safe kidney cut margin was determined by using ultrasonography during the operation. The renal artery was sparged with 10% papaverine hydrochloride to protect it from vasospasm [11] , and 100-200 mL of 20% D-mannitol was injected intravenously immediately before renal vessel clamping to reduce ischemic damage to the kidney [12] . Then, the renal artery and vein were clamped in an en block manner at the hilum with atraumatic forceps, and slushed ice was placed around the kidney to achieve core cooling.…”

Section: Surgical Proceduresmentioning

confidence: 99%

Renoprotective Procedures with a Cold Ischemia Time of <60 min Minimize the Deterioration of Kidney Function in Open Nephron-Sparing Surgery for Renal Cell Carcinoma

Nishida

Yamagishi²,

Yagi³

et al. 2017

Urol Int

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Introduction: We evaluated whether nephron sparing surgery (NSS) combined with meticulous suturing of the cut stump under clamping with cooling is beneficial for oncological outcomes and also assessed the relationship between cold ischemia time and deterioration of renal function. Methods: One hundred and six patients with renal cell carcinoma (RCC) were subjected to this procedure. Oncological outcomes and renal function according to the estimated glomerular filtration rate (eGFR) and the tubular excretion rate on renoscintigraphy before and at 12 months after surgery were evaluated. Results: Cancer recurrences were observed in 2 patients with past history of RCC; however, no patient died of cancer. Renal function was evaluated depending on 4 different ischemia times. All groups did not show a remarkable decrease of renal function in terms of eGFR. Renoscintigraphy revealed the deterioration of the affected kidney in patients with >60 min ischemia. Conclusion: The renoprotective procedure of NSS provided maximum preservation of renal function until 60 min of cold ischemia time.

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Section: Surgical Proceduresmentioning

confidence: 99%

Renoprotective Procedures with a Cold Ischemia Time of <60 min Minimize the Deterioration of Kidney Function in Open Nephron-Sparing Surgery for Renal Cell Carcinoma

Nishida

Yamagishi²,

Yagi³

et al. 2017

Urol Int

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Periarterial papaverine to treat renal artery vasospasm during robot-assisted laparoscopic partial nephrectomy

Sorokin

Stevens

Cadeddu³

2017

J Robotic Surg

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Renal artery vasospasm can be a troublesome complication during robot-assisted laparoscopic partial nephrectomy. Urologists performing this procedure, especially if utilizing selective arterial vascular microdissection, should be aware of using papaverine for both prevention and treatment of renal artery vasospasm. We present a 33-year-old male who developed severe renal artery vasospasm just with hilar dissection causing the kidney to become ischemic. Papaverine was topically applied on the renal arteries resulting in vasodilation and reperfusion of the kidney. Our objective of this report is to raise awareness of this complication as well as to review the literature on periarterial papaverine use and the dosing for topical applications.

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Safety and Facial Nerve Outcomes of Intracisternal Papaverine Irrigation for Vestibular Schwannoma Resection

et al. 2022

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Periarterial papaverine improves early postoperative renal function after retroperitoneoscopic partial nephrectomy

Abstract: As with laparoscopic donor nephrectomy, periarterial papaverine seems to improve postoperative renal function after retroperitoneoscopic partial nephrectomy. This nephroprotective effect might be particularly advantageous for patients with an impaired renal function preoperatively.

Cited by 3 publications

References 16 publications

Renoprotective Procedures with a Cold Ischemia Time of <60 min Minimize the Deterioration of Kidney Function in Open Nephron-Sparing Surgery for Renal Cell Carcinoma

Renoprotective Procedures with a Cold Ischemia Time of <60 min Minimize the Deterioration of Kidney Function in Open Nephron-Sparing Surgery for Renal Cell Carcinoma

Periarterial papaverine to treat renal artery vasospasm during robot-assisted laparoscopic partial nephrectomy

Safety and Facial Nerve Outcomes of Intracisternal Papaverine Irrigation for Vestibular Schwannoma Resection

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