Periapical Cytokine Expression in Sickle Cell Disease

Ferreira, Sebastião Rodrigo; Brito, Luciana Carla Neves de; Oliveira, Michelle Pimenta; Maciel, Kamilla Faria; Júnior, Hercílio Martelli; Vieira, Leda Quércia; Sobrinho, Antônio Paulino Ribeiro

doi:10.1016/j.joen.2014.11.016

Cited by 13 publications

(10 citation statements)

References 33 publications

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“…A recent study from our research group demonstrated that teeth with periapical lesions from SCA individuals presented prone proinflammatory ability, expressing IL-1, TNF-α, and IL-17A at a significantly higher level compared to healthy teeth from control patients. 32 In this study, 96.3% of the SCA patients presented hematocrit < 39% among male patients and < 36% among female patients. High hematocrit is a risk factor for vaso-occlusive crises, acute chest syndrome, and avascular necrosis, 30 and it has been suggested that hemoglobin level plays a role in the deformability of sickled cells.…”

Section: Discussionmentioning

confidence: 49%

Sickle cell anemia in Brazil: personal, medical and endodontic patterns

et al. 2016

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Sickle cell anemia (SCA) is the most prevalent genetic disease worldwide. Recurrent vaso-occlusive infarcts predispose SCA patients to infections, which are the primary causes of morbidly and mortality. This study aimed to evaluate the relationship between SCA and endodontic diseases. Personal information, medical data (hematological indices, virologic testing, blood transfusions, medications received, splenectomy) and information on the need for endodontic treatment were obtained from SCA patients who were registered and followed up by the Fundação Hemominas, Minas Gerais, Brazil.These data were compared with the need for root canal treatment in SCA patients. One hundred eight patients comprised the studied population, and the rate of the need for endodontic therapy was 10.2%. Among the medical data, a significant difference was observed for eosinophil (p = 0.045) counts and atypical lymphocyte counts (p = 0.036) when the groups (with and without the need for endodontic treatment) were compared. Statistical relevance was observed when comparing the patients with and without the need for root canal therapy concerned eosinophil counts and atypical lymphocyte counts. The differences in statistical medical data, observed between the groups suggest that both parameters are naturally connected to the stimulation of the immune system that can occur in the presence of root canal infections and that can be harmful to SCA individuals.

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Section: Discussionmentioning

confidence: 49%

Sickle cell anemia in Brazil: personal, medical and endodontic patterns

et al. 2016

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“…()––2 mm past WL602After Instrumenting7 daysqPCRTRIzol (−µL)10–25 at 12 000 g Ferreira et al . ()––2 mm past WL601After Instrumenting–qPCRTRIzol (−µL)10–25 at 12 000 g Martinho et al . ()Dentsply–Mai.152 mm past WL602After Instrumenting14 daysELISA––––Martinho et al .…”

Section: Resultsmentioning

confidence: 99%

A systematic review of methods used to sample and analyse periradicular tissue fluid during root canal treatment

et al. 2019

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Aim The primary aim was to identify techniques used to sample and analyse periradicular tissue fluid (PTF) in permanent teeth diagnosed with apical disease during root canal treatment. Secondly, to identify the types of inflammatory mediators studied using this approach. Methodology Data Sources: PubMed, EMBASE, Cochrane Library, Science Direct, Web of Science and OpenGrey. Eligibility Criteria: Clinical studies published until 1 June 2018 which utilized orthograde techniques to sample and analyse PTF were included. Cell culture, laboratory or animal studies and those concerned with investigating inflammatory mediator activity from within healthy or diseased pulp tissue, and not periradicular tissues, were excluded. Study appraisal and methods: In accordance with PRISMA guidelines, data were extracted on study characteristics, target mediators, sampling and assay techniques and the parameters associated with the PTF sampling and eluting protocol. A qualitative synthesis was conducted, and studies were critically appraised using a modified version of the Cochrane risk of bias tool. Results Study Characteristics: From 251 studies, 33 were eligible for inclusion. Sampling techniques included the use of paper points (n = 27), fine needle aspiration (n = 4) and filter strips (n = 2). Assay techniques included enzyme‐linked immunosorbent assay (n = 18), quantitative polymerase chain reaction (n = 9), radioimmunoassay (n = 4), colorimetric assay (n = 2), immunofluorometric assay (n = 1) and cytometric bead array (n = 1). Forty‐five different inflammatory mediators were targeted at the proteomic/metabolomic (n = 25) or transcriptomic level (n = 9). Limitations: Significant heterogeneity exists within the methodology, and only 5 studies disclosed unambiguous information about their PTF sampling and eluting protocols. Conclusions Paper points and proteomic/metabolomic analysis are currently the preferred methods for studying and analysing PTF during root canal treatment. The most studied analytes were IL‐1β and TNF‐α. Implications: Further research is required to develop an optimized PTF sampling and eluting protocol to overcome methodological heterogeneity, and future studies are advised to follow a standardized approach to reporting their methodology.

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“…Studies that have evaluated the need for endodontic treatment in different communities have found values that are much less expressive than those observed here. These values were 14%, 10.2%, and 23.2% in HIV-positive patients, 4 in patients with sickle cell disease, 5 and in patients undergoing bone marrow transplantation, 6 respectively. In this study, the Sateré-Mawé ethnic group presented a higher prevalence of endodontic treatment compared to the Tikuna ethnic group, which can be explained by the great difficulty of access to dental health services and the absence of educational and preventive actions to promote oral health.…”

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confidence: 89%

Epidemiological analysis and need for endodontic treatment among the indigenous Sateré-Mawé and Tikuna

et al. 2018

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The objective of this study was to analyze the epidemiological profile of oral health of Sateré-Mawé indigenous people living in Barreirinha, Amazonas (AM), Brazil, and the Tikuna indigenous people living in the urban area of Manaus (AM), in addition to characterizing the need for endodontic treatment between the two ethnic groups. A total of 138 individuals participated in the study, of whom 98 were Tikuna and 40 were Sateré-Mawé; they were distributed in age groups ranging from seven to 75 years. A very high prevalence of caries was observed in both ethnic groups. For the Sateré-Mawé in the 7-12 age group, the decayed, missing, and filled teeth (DMFT) index presented a mean value of 3.17. Comparing the DMFT index and the need for endodontic treatment in each of the ethnicities, these variables were found to be correlated, because as the DMFT index increases, the chances of needing endodontic treatment increase. The Sateré-Mawé presented a higher prevalence of need for endodontic treatment compared to the Tikuna. The association of comorbidities and the need for endodontic treatment were demonstrated only in the Tikuna, and there was only a correlation of this necessity with the presence of diabetes mellitus (DM) in one case. The need to expand access to oral health in these communities is emphasized, taking into account geographical access and technological, environmental, linguistic, and cultural barriers.

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Periapical Cytokine Expression in Sickle Cell Disease

Cited by 13 publications

References 33 publications

Sickle cell anemia in Brazil: personal, medical and endodontic patterns

Sickle cell anemia in Brazil: personal, medical and endodontic patterns

A systematic review of methods used to sample and analyse periradicular tissue fluid during root canal treatment

Epidemiological analysis and need for endodontic treatment among the indigenous Sateré-Mawé and Tikuna

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