Perianal ulcers and erosions after using an anti-hemorrhoid ointment

Contact dermatitis associated with an anti‐haemorrhoidal ointment containing ephedrine and benzocaine: Case report and literature review

“…In line with previous hypotheses on topical steroid‐associated ulcers, the atrophic and vasoconstrictive properties of triamcinolone acetonide adding to lidocaine's neuropathic‐like effect, were the most probable suggested triggers for PU in their specific demographic (mainly obese patients of low sociocultural status who overused the AO) 1,2 . Since then, two other cases of AO‐linked PU (also with Anso®) have been reported 3,4 …”

“…1,2 Since then, two other cases of AO-linked PU (also with Anso ® ) have been reported. 3,4 Contrarily, Hemoal Forte ® contains no corticosteroids but ephedrine (2 mg/g), potentially causing sympathomimetic vasoconstrictive effects, and benzocaine (60 mg/g), an ester-like local anaesthetic, extensively known for its allergenic properties that have also been described as an irritative cause of perianal erosive dermatitis in several patients. 5,6 However, most reported similar cases (of great clinical and histological resemblance to our case) with erosive dermatitis or cutaneous ulcerations associated with AO or other topical drugs collected by a literature review (Table 1), failed to sufficiently exclude contributing ACD since in most of them either questionable patch test results were presented or no patch test was performed at all.…”

“…5,6 However, most reported similar cases (of great clinical and histological resemblance to our case) with erosive dermatitis or cutaneous ulcerations associated with AO or other topical drugs collected by a literature review (Table 1), failed to sufficiently exclude contributing ACD since in most of them either questionable patch test results were presented or no patch test was performed at all. [1][2][3][4][5][6][7][8][9][10] Nevertheless, persistent use of topical preparations on a disrupted cutaneous barrier is a well-known contact-sensitization risk factor, especially in the anogenital region due to humidity, friction and occlusion. 10 Hence, we believe that although ACD might be interpreted as a collateral factor in our patient, it played an essential role in the development and perpetuation of her lesions.…”

痔疮止痛浸膏熏洗坐浴护理肛肠疾病术后疼痛水肿

“…和解表散风 [8] ；防风能够止痉、胜湿止痛和祛风解表。 诸药联合具有胜湿止痛、清热消炎等功效，能阻碍炎症 渗出，减轻疼痛，消散水肿。引入该药物，术后为患者 提供中药熏洗，能有效减轻水肿、疼痛 [9] 。采取综合护 理，同时选取痔疮止痛浸膏，予以患者熏洗坐浴，能有 效缓解疼痛，减轻水肿，取得良好预后 [10][11] 。本次研究 [ 5 ] 王 幸 , 殷 婷 , 孙 苗 , 等 .…”