Perianal Paget's Disease Treated with Wide Excision and Gluteal Skin Flap Reconstruction: Report of a Case and Review of the Literature

Gaertner, Wolfgang B.; Hagerman, Gonzalo; Goldberg, Stanley M.; Finne, Charles O.

doi:10.1007/s10350-008-9409-y

Cited by 21 publications

(27 citation statements)

References 31 publications

(34 reference statements)

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“…However, CK20+/GCDFP15− is also a possible presentation and tends to have a higher recurrence rate [10]. This pathology has been demonstrated in patients with associated rectal adenocarcinoma and endodermal differentiation with gastrointestinal-type glands [9]. The patient presented here was CK20+, which prompted us to be more aggressive in his treatment.…”

Section: Discussionmentioning

confidence: 88%

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Management of Adenocarcinoma in the Setting of Recently Operated Perianal Paget's Disease

Clark

Schlussel

Gagliano

2013

Case Reports in Surgery

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Perianal Paget's disease only rarely presents with a synchronous invasive anal or rectal cancer. The purpose of this study is to present a case of an otherwise healthy patient who developed perianal Paget's disease. He was then found to have an invasive rectal adenocarcinoma, after having undergone an extensive resection and reconstruction with a bilateral V-to-Y reconstruction. This report describes an overview of perianal Paget's disease, the management of this disease in association with anal or rectal cancer, and our patient's outcome.

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Section: Discussionmentioning

confidence: 88%

“…The histogenesis is controversial, but there are four main theories [9]. The first is that Paget's disease cells may arise from underlying carcinoma of the apocrine or eccrine sweat glands by continuity.…”

Section: Discussionmentioning

confidence: 99%

Management of Adenocarcinoma in the Setting of Recently Operated Perianal Paget's Disease

Clark

Schlussel

Gagliano

2013

Case Reports in Surgery

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“…In large defects, a temporary diversion of the colon is frequently used. [8,9,27,34] Other treatment options for primary PPD have been suggested for patients not fit for surgery or in cases who refuse surgery or would need mutilating surgery in a delicate region. Radiotherapy can be considered as an alternative therapy but doses of 50 Gy or more are advocated, lower doses are associated with high …”

Section: Discussionmentioning

confidence: 99%

Perianal Paget’s disease: case report and review of the literature

Bontinck

Rondou³

et al. 2016

Acta Chirurgica Belgica

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A peri-anal skin lesion, often eczema-like and with symptoms of pruritus, that does not resolve after classical local therapy should be biopsied. We present a case of peri-anal extramammary Paget's disease (EMDP) and associated anal adenocarcinoma. Reviewing the literature, more than 30% of patients with EMDP present a second primary tumour in their past, present or future history. In Europe, the risk of developing a new primary tumour in patients with this condition is increased compared with the standard population. In cases of peri-anal Paget's disease (PPD), specific histochemical markers allow us to differentiate between a primary and a secondary form, the secondary one is strongly associated with colorectal and anal tumours. We provide information about the most commonly suggested therapy for PPD with or without associated malignancy and about the recommended follow-up.

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“…Shutze and Gleysteer [16] proposed a staging classification for perianal Paget's disease with a description of each stage and the recommended therapy (Table 1). Treatment is essentially surgical, with wide local excision the preferred approach for noninvasive, locally confined disease [13,[17][18][19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Double anal canal cancers associated with a long history of perianal Paget’s disease: report of a case

et al. 2012

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Extramammary Paget's disease (EPD) is rare. We report a case of double anal canal cancers in a patient with a long history of perianal Paget's disease. The patient, a 68-year-old Japanese woman, refused surgery initially and was treated with electron beam therapy, which achieved remission. However, 6 years later, Paget's disease was found to be progressing again and double anal canal tumors were also detected in the proctos and external skin area. We performed abdominoperineal resection (Miles' operation) and lymph node dissection for the Paget's disease with double anal canal tumors. Immunohistochemical staining revealed cytokeratin (CK)-20 expression in the adenocarcinomas and Paget's disease lesion, but not CK-7 or gross cystic disease fluid protein-15 expression. The lesion was joined to the carcinoma by a stalk. The immunohistochemistry results suggested secondary EPD, although it was originally considered to be Paget's carcinoma (primary EPD) based on the clinical history.

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Perianal Paget's Disease Treated with Wide Excision and Gluteal Skin Flap Reconstruction: Report of a Case and Review of the Literature

Abstract: Perianal Paget's disease continues to pose problems in diagnosis and treatment. Our case report of perianal Paget's disease shows one method of management for advanced non invasive disease.

Cited by 21 publications

References 31 publications

Management of Adenocarcinoma in the Setting of Recently Operated Perianal Paget's Disease

Management of Adenocarcinoma in the Setting of Recently Operated Perianal Paget's Disease

Perianal Paget’s disease: case report and review of the literature

Double anal canal cancers associated with a long history of perianal Paget’s disease: report of a case

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