Perianal mucinous adenocarcinoma arising from chronic anorectal fistulae: a review from a single institution

Abstract

A high index of clinical suspicion is required to make the diagnosis of perianal tumours while assessing patients presenting with perianal inflammatory conditions. Wide excision of the tumour with abdominoperineal resection is the surgical treatment of choice and can provide good long-term results in patients with localized disease.

Fistula-Associated Anal Adenocarcinoma: Good Results with Aggressive Therapy

“…Adenocarcinomas and squamous-cell carcinomas have both arisen in nonhealing fistula tracts (Table 4). 7,8,[18][19][20][21][22][23][24][25][26][27] Long-standing fistulas of the gastrointestinal and bronchopulmonary systems have been the most widely affected by malignant transformation. [28][29][30] Chronic infection and inflammation (i.e., Crohn's disease and radiation) are the most frequently associated risk factors.…”

Mucinous adenocarcinoma arising from recurrent perianal fistula in patient with Crohn's disease: case report

“…7 Clinically the patient may manifest pain and rectal bleeding, anal abscess, perianal mass and edema and chronic discharge. 1,2,8,9 Digital rectal examination (DRE) may reveal only a hardened area adjacent to the fistula. 10 Furthermore, the stenosis and anal pain may limit the physical examination, delaying the diagnosis.…”

“…1 Furthermore, the diagnosis of mucinous adenocarcinoma is difficult, due to the presence of other simultaneous conditions such as Paget's disease, leukoplakia, hemorrhoids and fissures. 2 Endorectal ultrasonography, computed tomography (CT) and magnetic resonance imaging are tests that can assess the extent of the disease. 1,5 However, sometimes these methods are not very useful.…”

MRI Findings of Mucinous Adenocarcinoma Arising From Perianal Fistula: Report of Two Cases

“…The carcinoma develops on the chronic setting of the disease (1,2,3). Patients with perianal fistula usually present with purulent discharge and pain (4).…”