Perianal Median Raphe Cyst: A Rare Lesion with Unusual Histology and Localization

Ünal, Betül; Başsorgun, Cumhur İ̇brahim; Karanis, Meryem İlkay Eren; Elpek, Gülsüm Özlem

doi:10.1155/2015/487814

Cited by 6 publications

(7 citation statements)

References 12 publications

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“…We would like to extend this classification and add two more categories: ciliated and pigmented. The ciliated type is characterized by the presence of ciliated cells interspersed with pseudostratified [16, 26, 47, 56] or columnar [31, 57, 58] epithelium. The pigmented variant appears brown-black in color due to the presence of melanocytes and melanin pigment in the epithelial lining [10, 46, 50].…”

Section: Discussion and Reviewmentioning

confidence: 99%

“…Unal et al [56], in their compilation of cases of ciliated cysts, mentioned six cases, including their own, as documented in the literature. Perhaps they missed the case reported by Navarro et al .…”

Section: Discussion and Reviewmentioning

confidence: 99%

“…Excision is associated with excellent results, with no evidence of recurrence in 6 months [36], 1 year [34, 45], and 4 years [56] of follow-up. In a case series with six patients, Asarch et al noted recurrence in one of the patients after 5 years, and the cyst was reexcised with no subsequent recurrence [7].…”

Section: Discussion and Reviewmentioning

confidence: 99%

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Median raphe cyst of the penis: a case report and review of the literature

2019

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Background A defect in embryological development or closure of median raphe may lead to formation of cyst(s) anywhere in the midline from glans to anus. These cysts are referred to as median raphe cysts, an uncommonly encountered clinical condition. The cyst is generally solitary, with the penile shaft being the most common location, with average size of around 1 cm. The diagnosis is mostly clinical and confirmed histologically. We report a case of a patient with a rare histological variant of median raphe cyst and provide a focused review on presentation, histopathology, and management. Case presentation A 29-year-old unmarried Nepali man presented to our clinic with an asymptomatic, solitary, soft, translucent, nontender cystic lesion of about 1-cm diameter at the ventral aspect of glans penis, close to the meatus, that had been noticed at the age of 3 and was nonprogressive for the past 15 years. Ultrasonography demonstrated an isoechoic cystic lesion at the tip of the penis, separated from the urethra, and lying entirely within the mucosa without any evidence of solid component, septation, or vascularity. On the basis of clinical and ultrasonographic findings, a diagnosis of median raphe cyst of the penis was made. The cyst was excised with the patient under local anesthesia, and there was no evidence of recurrence in 2 years of follow-up. The histopathological examination with Hematoxylin and eosin staining showed the cyst wall was lined partly by ciliated pseudostratified columnar epithelium and partly by columnar epithelium with apical mucin. Conclusions Median raphe cyst is an uncommon, mostly asymptomatic condition in young patients. The cyst may occur anywhere along the midline from glans to anus. The diagnosis is clinical with histological confirmation. Excision is the treatment of choice with minimal chance of recurrence.

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Section: Discussion and Reviewmentioning

confidence: 99%

Section: Discussion and Reviewmentioning

confidence: 99%

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Median raphe cyst of the penis: a case report and review of the literature

2019

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“…MRCs can theoretically develop anywhere along the midline from meatus to anus, including parameatus, 9 glans penis, 10,19 penile shaft, 3–5,11,14,15 scrotum, 12 perineum, 7,10 and perianal, 6,16 but they present most commonly in the penile shaft 13 . MRCs commonly appear in childhood or adolescence, with a bimodal distribution at approximately 1–10 and 21–40 years old 13,17,18 .…”

Section: Discussionmentioning

confidence: 99%

“…MRCs are rare benign lesions of the male genitalia that can develop at any site along the midline from meatus to anus (i.e. parameatus, glans penis, penile shaft, scrotum, perineum, or perianal) 1–19 . The condition was first described by Mermet in 1895, 1 and MRC is currently believed to be caused by a defect in closure of the median raphe during embryonic development 19 .…”

Section: Introductionmentioning

confidence: 99%

Pigmented median raphe cyst of the penis that developed after middle age without infection or trauma history

Kii

Taguchi²,

Nagahama

et al. 2021

IJU Case Reports

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Introduction Median raphe cysts are rare benign lesions of the male genitalia that can develop anywhere along the midline from meatus to anus. They are believed to be caused by a defect in closure of median raphe during embryonic development. These cysts commonly appear in childhood or adolescence, although some are diagnosed after middle age, typically triggered by infection or trauma. Pigmented median raphe cysts, or those containing melanin pigment and/or melanocytes, are extremely rare. Case presentation A 78‐year‐old man visited our hospital with a complaint of a penile mass that he first noticed in his 50s which slowly grew, eventually causing voiding difficulty. He had no history of infection or trauma. The lesion was excised, and the pathological diagnosis was pigmented median raphe cyst. Conclusion We successfully treated a rare case of pigmented median raphe cyst of the penis that developed after middle age without infection or trauma history.

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