Perianal acquired tufted angioma associated with pregnancy: case report

Abstract

Tufted angiomas are rare lesions described as slowly growing/spreading erythematous macules especially located in the upper trunk and neck. Herein we report the case of perianal location of a tufted angioma in a young pregnant woman. She came to our observation complaining of perianal pain accompanied by bleeding at defecation. A lesion resembling a perianal fissure was observed. Mild hypertonia of the internal sphincter was confirmed at manometry. After one week of ineffective medical treatment, surgery was planed at the end of the sixteenth week under local anaesthesia. The lesion was excised and a minimal sphincterotomy was performed; histopathology report described features of a tufted angioma. The pregnancy proceeded regularly, without anal symptoms, followed by normal vaginal delivery at the thirty-eighth week. This case showed three peculiar features: the association of tufted angioma and pregnancy, the perianal location, and the clinical appearance suggestive of an anal fissure. The clinical manifestation of a perianal tufted angioma, mimicking an anal fissure, is of utmost importance to the differential diagnosis and treatment plan, especially in a pregnant woman.

Adult-Onset Tufted Angiomas Associated With an Arteriovenous Malformation in a Renal Transplant Recipient

“…Our review of the English literature revealed 9 additional patients who developed TA in adulthood. 3,[13][14][15][16][17][18] In rare instances, adult-onset TA has been reported in pregnancy, [19][20][21] varicella zoster virus infection, 14 and pharmacological immunosuppression. 17,22 The present case shows peculiar features both clinically and histopathologically.…”

Kasabach–Merritt phenomenon in an adult man with a tufted angioma and cirrhosis responding to radiation, bevacizumab, and prednisone

“…In one report reviewing 211 cases of TA, only 16% started after age 30 . We identified 25 published cases of adult‐onset TA in the English literature, none of which was reportedly associated with KMP (Table ) …”

Oral itraconazole for the treatment of giant tufted angioma with hair loss arising during pregnancy: A case report

“…1,2 We report a case of huge tufted angioma arising during pregnancy with severe pain and hair loss, resulting in the improvement of the symptoms and hair regrowth by oral itraconazole. 1,2 We report a case of huge tufted angioma arising during pregnancy with severe pain and hair loss, resulting in the improvement of the symptoms and hair regrowth by oral itraconazole.…”

“…Dear Editor, Tufted angioma or Nakagawa angioblastoma is a benign angiogenic neoplasm of pediatric populations rarely reported in adulthood and pregnancy. 1,2 We report a case of huge tufted angioma arising during pregnancy with severe pain and hair loss, resulting in the improvement of the symptoms and hair regrowth by oral itraconazole.…”

“…Pregnancy could be a predisposing factor for vascular proliferation, indicating estrogen promoting its development. 1,2 Tufted angioma may occur in hypertrichosis and hyperhidrosis; 2 however, hair loss was never reported. It was regretful that the histopathology of hair loss was not collected.…”