Peri‐partum Changes in the Intraepithelial Lymphocyte Population of Sheep Interplacentomal Endometrium

Abstract

Our results demonstrated that the dramatic decline in the proportion of gammadeltaTCR+ LGLs at parturition was because of de-granulation, apoptosis and migration of these cells into the uterine lumen.

Changes in white blood cells in sheep blood during selenium supplementation

“…According to Entrican et al (2002) the development of an embryo in the maternal organism is accompanied by a higher stress on the immunity system consisting in the establishment of mother's immunotolerance to the embryo's extraneous antigens. Based on histological examinations of Nasar et al (2002) it is to assume that the onset of immunotolerance in pregnant ewes is concentrated in the uterine tissue whereas the proportions of lymphocyte subsets in the peripheral blood are not influenced. According to Barrington and Parish (2001) CD4 + ( Figure 3) and CD8 + (Figure 4) subsets are increasing when the antigen pressure increases, which corresponds to a higher risk of infections in the puerperal period requiring the enhancement of mother's immunity system.…”

“…A possibility of T lymphocyte differentiation by receptors CD4 + and CD8 + (Park et al, 2004) improves the information on a potential impact of selenium supplementation on immunity processes in the period of pregnancy. Peripartal changes in intraepithelial lymphocytes in ewes were studied in the uterine tissue by Nasar et al (2002), who determined a decrease in the white blood cell count in the uterine stroma.…”

Symposium review: Immunological detection of the bovine conceptus during early pregnancy

“…Several studies have examined the endometrial transcriptome during the periattachment period in cattle, and these studies consistently identify immune function genes and pathways as being the most highly regulated during early pregnancy Walker et al, 2010;Cerri et al, 2012;Bauersachs and Wolf, 2015). Fewer studies focus on changes in uterine immune cell populations in ruminants during this same time (Leung et al, 2000;Oliveira et al, 2013;Kamat et al, 2016;Vasudevan et al, 2017) compared with more extensive literature for later pregnancy and the periparturient period (Nasar et al, 2002;Tekin and Hansen, 2002;Hansen, 2008, 2009;Oliveira et al, 2010;Fox et al, 2010). Furthermore, much of the work in this field occurred more than 15 yr ago, when cellular morphology alone (Vander Wielen and King, 1984) or poorly characterized antibodies (Gongolin-Ewens , 1989;Lee et al, 1988) were used to identify immune cell populations.…”

Lymphocyte migration studies

“…As in the mammary gland, lymphocyte migration in uterine tissue is greatly influenced by hormonal changes during pregnancy. Furthermore, differences in subset composition and migration patterns have been demonstrated for tissue areas with or without contact to the conceptus [20,38,46].…”