Peri-conception folic acid supplementation knowledge and associated factors among women visiting Maternal and Child Health clinics in Addis Ababa, Ethiopia

Fekadu, Mesfin; Ketema, Kassahun; Mamo, Yitagesu; Aferu, Temesgen

doi:10.1016/j.heliyon.2022.e11114

Cited by 3 publications

(7 citation statements)

References 37 publications

(51 reference statements)

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“…In connection with this, per our review, intake of folic acid at preconception and during the early stages of pregnancy has reduced the risk of giving birth to a child with NTDs. However, utilisation of folic acid is more skewed to those who are educated and those who visited a health facility for ANC and family planning services due to better knowledge and access to utilisation 119 120. To this effect, women who had ANC visits had better access to use folic acid, which significantly lowered the risk of NTDs as portrayed in our review as well.…”

Section: Discussionmentioning

confidence: 68%

“…The meta-analysis of 45 studies also illustrated45 those uneducated women have a higher risk of giving birth to a child with NTDs. In Ethiopia, only a limited number of women were aware of and had access to periconceptional folic acid usage to avert the untoward consequence of NTDs, except for women residing in urban areas 118–121. In connection with this, per our review, intake of folic acid at preconception and during the early stages of pregnancy has reduced the risk of giving birth to a child with NTDs.…”

Section: Discussionmentioning

confidence: 94%

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Birth prevalence and risk factors of neural tube defects in Ethiopia: a systematic review and meta-analysis

Tesfay,

Hailu,

Habtetsion

et al. 2023

BMJ Open

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ObjectiveThis study aims to estimate the prevalence of neural tube defects (NTDs) and to identify potential risk factors in the Ethiopian context.Study designSystematic review and meta-analysis.Study participantsA total of 611 064 participants were included in the review obtained from 42 studies.MethodsPubMed (Medline), Embase and Cochrane Library databases in combination with other potential sources of literature were systematically searched, whereby studies conducted between January 2010 and December 2022 were targeted in the review process. All observational studies were included and heterogeneity between studies was verified using Cochrane Q test statistics and I2test statistics. Small study effects were checked using Egger’s statistical test at a 5% significance level.ResultThe pooled prevalence of all NTDs per 10 000 births in Ethiopia was 71.48 (95% CI 57.80 to 86.58). The between-study heterogeneity was high (I2= 97.49%, p<0.0001). Birth prevalence of spina bifida (33.99 per 10 000) was higher than anencephaly (23.70 per 10 000), and encephalocele (4.22 per 10 000). Unbooked antenatal care (AOR 2.26, 95% CI (1.30 to 3.94)), preconception intake of folic acid (AOR 0.41, 95% CI (0.26 to 0.66)), having chronic medical illness (AOR 2.06, 95% CI (1.42 to 2.99)), drinking alcohol (AOR 2.70, 95% CI (1.89 to 3.85)), smoking cigarette (AOR 2.49, 95% CI (1.51 to 4.11)), chewing khat (AOR 3.30, 95% CI (1.88 to 5.80)), exposure to pesticides (AOR 3.87, 95% CI (2.63 to 5.71)), maternal age ≥35 (AOR 1.90, 95% CI (1.13 to 3.25)), maternal low educational status (AOR 1.60, 95% CI (1.13 to 2.24)), residing in urban areas (AOR 0.75, 95% CI (0.58 to 0.97))and family history of NTDs (AOR 2.51, 95% CI (1.36 to 4.62)) were associated with NTD cases.ConclusionThe prevalence of NTDs in Ethiopia is seven times as high as in other Western countries where prevention measures are put in place. Heredity, maternal and environmental factors are associated with a high prevalence of NTDs. Mandatory fortification of staple food with folic acid should be taken as a priority intervention to curb the burden of NTDs. To smoothen and overlook the pace of implementation of mass fortification, screening, and monitoring surveillance systems should be in place along with awareness-raising measures.PROSPERO registration numberCRD42023413490.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 94%

Birth prevalence and risk factors of neural tube defects in Ethiopia: a systematic review and meta-analysis

Tesfay,

Hailu,

Habtetsion

et al. 2023

BMJ Open

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“… 36 Facility-based and media-based campaigns can be a good approach to raising awareness about the importance and timely initiation of folic acid in the childbearing period. 13 , 34 , 41 …”

Section: Discussionmentioning

confidence: 99%

“…Moreover, our study did not collect as much information about ethnicity as compared to other studies, 32 given that Gadarif State is a multiethnic society. 26 Other factors that may lead to low folic acid supplementation in periconceptional period such as lack of knowing the importance for the fetal development, difficulty in getting folic acid, low socioeconomic status, and the culture background of the family 12 – 14 were not investigated. Furthermore, information about the correlation of folic acid usage with serum folic acid levels is limited, as several dietary sources can contain folic acid, and dietary habits such as fruit and vegetables intake 29 are crucial and can be obtained in future research.…”

Section: Discussionmentioning

confidence: 99%

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Periconceptional folic acid usage and its associated factors in eastern Sudan: A cross-sectional study

Hassan,

Bashir

et al. 2024

Womens Health (Lond Engl)

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Background: Several countries poorly adhere to the World Health Organization’s recommendation of folic acid supplementation in the periconceptional period, especially in limited-resource settings. Objective: The objective of this study was to investigate the prevalence of and the factors associated with folic acid usage in the periconceptional period among pregnant women at Gadarif Maternity Hospital in eastern Sudan. Study design: This is a cross-sectional study. Methods: This study was conducted in eastern Sudan from April to September 2022. A total of 720 pregnant women in their first trimester were enrolled. The sociodemographic characteristics and clinical and obstetrical data of pregnant women in their first trimester were assessed using a face-to-face questionnaire. In addition, multivariate regression analysis was performed. Results: In this study, the median (interquartile range) of the age and gravidity of the enrolled women was 26.3 (24.14–29.52) years and 2 (1–4), respectively. Of these 720 women, 423 (58.8%) used folic acid during the periconceptional period, while 27 (3.7%) women used folic acid in the preconceptional period. None of the investigated factors (age, residence, education, employment, body mass index, or gravidity) were associated with periconceptional use of folic acid. Conclusion: The study revealed a low prevalence of folic acid usage in preconceptional period among pregnant women in eastern Sudan. Additional efforts are needed to promote folic acid usage in the preconceptional period as well as in the first trimester.

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Effects of folic acid and folic acid plus zinc supplements on the sperm characteristics and pregnancy outcomes of infertile men: A systematic review and meta-analysis

Zeng

Luo

et al. 2023

Heliyon

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Peri-conception folic acid supplementation knowledge and associated factors among women visiting Maternal and Child Health clinics in Addis Ababa, Ethiopia

Cited by 3 publications

References 37 publications

Birth prevalence and risk factors of neural tube defects in Ethiopia: a systematic review and meta-analysis

Birth prevalence and risk factors of neural tube defects in Ethiopia: a systematic review and meta-analysis

Periconceptional folic acid usage and its associated factors in eastern Sudan: A cross-sectional study

Effects of folic acid and folic acid plus zinc supplements on the sperm characteristics and pregnancy outcomes of infertile men: A systematic review and meta-analysis

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