Peri-anaesthetic mortality and nonfatal gastrointestinal complications in pet rabbits: a retrospective study on 210 cases

Lee, Hoi W.; Machin, Hanna; Adami, Chiara

doi:10.1016/j.vaa.2018.01.010

Cited by 46 publications

(45 citation statements)

References 21 publications

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“…59,60 Moreover, the rabbit is considered a risk species for anesthetic complications which increases the impact of removing or decreasing the burden of anaesthesia from the experimental design. 61,62 Our OCT-histology comparisons demonstrate that the VS is best defined on OCT as a 2 mm wide horizontal band centered 3 mm below the ventral ONH rim ( Fig. 5 and Supplementary Figure S3).…”

Section: Discussionmentioning

confidence: 85%

Spectral Domain Optical Coherence Tomography in Awake Rabbits Allows Identification of the Visual Streak, a Comparison with Histology

Lavaud

Soukup

Martin

et al. 2020

Trans. Vis. Sci. Tech.

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To evaluate visual streak (VS) identification on spectral-domain optical coherence tomography (SD-OCT) scans in awake rabbits. To report thickness measurements in the VS and adjacent retina on OCT B-scans and histologic sections and to assess intermethod bias, precision and repeatability between OCT and histology. Methods: Vertical SD-OCT B-scan images through the optic nerve head and VS were acquired from 16 awake, ophthalmologically healthy experimental rabbits. Scans were acquired from both eyes, which were later enucleated and processed for light microscopy. Inner retina, inner nuclear layer, outer nuclear layer, outer retina (OR) and photoreceptor outer segment (PROS) thickness were measured on OCT images and digitalized microscopy slides in-and outside of the VS, and compared using linear mixed effects models. Results: Both SD-OCT and histology allowed retinal layer identification and measurement. On OCT, OR and PROS were thickest in the central VS and thinnest outside the VS. Histology mirrored OCT results for central outer retinal layers but shows discrepancies for other layers likely because of postmortem processing artifacts. The method comparison demonstrated better repeatability for OCT measurements compared with histology. Conclusions: Increased OR and PROS thickness compared with the adjacent retina allowed identification of the VS on SD-OCT in awake rabbits. OCT allows measurements devoid of processing artifacts in contrast to histology. Translational Relevance: SD-OCT is possible in awake rabbits. Easy and reliable identification of the VS may facilitate the positioning and use of rabbits as model species in human macular and generalized retinal disease research

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Section: Discussionmentioning

confidence: 85%

Spectral Domain Optical Coherence Tomography in Awake Rabbits Allows Identification of the Visual Streak, a Comparison with Histology

Lavaud

Soukup

Martin

et al. 2020

Trans. Vis. Sci. Tech.

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“…All studies had a low risk of bias, except the ones of Clarke and Hall ( 19 ) and Lee et al ( 35 ), which had a moderate risk of bias. The study of Clarke and Hall ( 19 ) mentioned that animals died during or shortly after surgery but they did not specify the exact length of follow-up.…”

Section: Resultsmentioning

confidence: 98%

“…The study of Clarke and Hall ( 19 ) mentioned that animals died during or shortly after surgery but they did not specify the exact length of follow-up. Lee et al ( 35 ) assigned the ASA PS score retrospectively from the animal records.…”

Section: Resultsmentioning

confidence: 99%

“…All studies excluded animals that died due to euthanasia from the analysis, except for the studies of Clarke and Hall ( 19 ), Brodbelt et al ( 24 ), and Lee et al ( 35 ).…”

Section: Resultsmentioning

confidence: 99%

“…In veterinary medicine, to the authors' knowledge, one of the first prospective publications mentioning the association between the ASA PS classification and the anesthesia-related risk of death was from Clarke and Hall ( 19 ). Since then, several studies associating the ASA PS to anesthesia-related risk of death were published for dogs and cats ( 20 – 34 ), rabbits ( 24 , 35 ), pigs ( 36 ), and horses ( 37 , 38 ) with different outcomes and definitions. However, whether veterinary patients with a high ASA PS score are at an increased risk of death and development of complications associated with anesthesia remains unknown.…”

Section: Introductionmentioning

confidence: 99%

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The ASA Physical Status Classification: What Is the Evidence for Recommending Its Use in Veterinary Anesthesia?—A Systematic Review

Portier

Ida

2018

Front. Vet. Sci.

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Background: The effectiveness of the American Society of Anesthesiologists (ASA) Physical Status (PS) classification to identify the animals at a greater risk of anesthesia-related death and complications is controversial. In this systematic review, we aimed to analyze studies associating the ASA PS scores with the outcome of anesthesia and to verify whether there was any evidence for recommending the use of the ASA PS in veterinary patients.Methods: Research articles found through a systematic literature search were assessed for eligibility, and data were extracted and analyzed using random-effects analysis.Results: A total of 15 observational prospective and retrospective studies including 258,298 dogs, cats, rabbits, and pigs were included. The analysis found consistency between the studies showing that dogs, cats and rabbits with an ASA-PS ≥III had 3.26 times (95% CI = 3.04–3.49), 4.83 times (95% CI = 3.10–7.53), and 11.31 times (95% CI = 2.70–47.39), respectively, the risk of anesthesia-related death within 24 h (dogs) and 72 h (cats and rabbits) after anesthesia compared with those with an ASA PS

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Anesthetic process

Kushnir¹,

McKune²

2022

Small Animal Anesthesia Techniques

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Peri-anaesthetic mortality and nonfatal gastrointestinal complications in pet rabbits: a retrospective study on 210 cases

Cited by 46 publications

References 21 publications

Spectral Domain Optical Coherence Tomography in Awake Rabbits Allows Identification of the Visual Streak, a Comparison with Histology

Spectral Domain Optical Coherence Tomography in Awake Rabbits Allows Identification of the Visual Streak, a Comparison with Histology

The ASA Physical Status Classification: What Is the Evidence for Recommending Its Use in Veterinary Anesthesia?—A Systematic Review

Anesthetic process

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