PERG and spectral sensitivity in ocular hypertensive and chronic open-angle glaucoma patients

Bielik, Magda; Zwas, Fred; Shin, Dong Ho

doi:10.1007/bf00166299

Cited by 11 publications

(4 citation statements)

References 21 publications

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“…Especially in early diagnosis of glaucoma it seems to be useful because amplitude reduction can indicate early glaucomatous damage [1,5,9,10,25,26,29,36,38,42,43,44]. However, this patient group covers an age range where retinal contrast is impaired by factors like media opacity, subop-timal accomodation, and small pupil size [20,22,33,34,39].…”

Section: Introductionmentioning

confidence: 99%

The contrast characteristic of the pattern electroretinogram depends on temporal frequency

Zapf

Bach

1999

Graefe's Archive for Clinical and Experimental Ophthalmology

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Section: Introductionmentioning

confidence: 99%

The contrast characteristic of the pattern electroretinogram depends on temporal frequency

Zapf

Bach

1999

Graefe's Archive for Clinical and Experimental Ophthalmology

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“…PERG is altered in glaucoma and in many cases of OHT, 9 even if in some case with OHT PERG may be normal. 10 Several authors in human studies found PERG as a predictive value to identify those patients with elevated IOP who develop a glaucoma before visual field changes occur. 11,12 PERG has higher sensibility to detect glaucomatous changes 12,13 and it is abnormal in most patients with manifest disease.…”

Section: Introductionmentioning

confidence: 99%

Integrated electrophysiological evaluation in early normal-tension glaucoma

Messenio

Marano

Biganzoli

2016

MAIO

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Purpose: To evaluate the variations of intraocular pressure (IOP), morphometric optic nerve head characteristic, perimetric indices and electrophysiological parameters (pattern electroretinogram and visual evoked potentials) before and after topical IOP lowering in patients with early normal-tension glaucoma.Methods: we evaluated 38 eyes of 20 patients with IOP < 21 mmHg, initial glaucomatous optic neuropathy (valued with HRT: retinal nerve fiber layer thickness (RNFL) and linear cup/disk ratio (linear C/D ratio)), minimal visual field defects (Octopus 101: G2 program), best correct visual acuity more than 15/20 and pathological electrophysiological parameters (valued with pattern electroretinogram (PERG) and visual evoked potentials (VEPs)), free of systemic or other ocular diseases. All parameters were evaluated at the beginning of the study (T0) and after 12 months of therapy (T12). A randomized normal control group (27 eyes of 14 subjects) with apparent larger disc cupping underwent all exams at initial of study (T0) and after 12 months (T12).Results: Among electrophysiological parameters, at the beginning of the study NTG P100 VEPs latency is slightly increased and P100 amplitude is reduced compared to normal subjects. There are not significant variations after 12 months. P50 PERG latency in NTG is quite similar respect normal and do not modify after therapy. P50N95 complex PERG amplitude in NTG is reduced compared to normal subjects and slightly increases after 12 months (1.8 vs 1.5 ; 2.4 vs 1.9 micronvolts, with different checkboard spatial frequency). Cortical retinal time (CRT) is slightly delayed in NTG and does not modify. Among visual field indices, MD and CLV is slightly higher in NTG and do not significantly modify after therapy. Among morphometric optic nerve head characteristics, linear C/D and RNFL thickness are quite similar in NTG and do not modify. IOP is quite similar between NTG and control group and modifies in NTG after therapy.Conclusion: In a viewpoint of an integrated diagnostic, electrophysiological tests (VEPs and PERG) could provide a more sensitive measure of retinal ganglion cell integrity and help to distinguish between early normal-pressure glaucoma patients with no or minimal visual field alterations and normal subjects with apparent larger disc cupping.

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“…[ 9 ] The general pattern is that BYP defects, although similar in location and shape, appear earlier and are larger than SAP defects. [ 10 11 12 13 ]…”

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confidence: 99%

Comparing retinal sensitivities on blue-on-yellow and green-on-yellow perimetry in glaucoma suspects

Pokal

Swathi

Rajalakshmi

et al. 2022

Indian Journal of Ophthalmology

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Purpose: To compare the retinal sensitivities between the blue-on-yellow perimetry (BYP)/short-wavelength automated perimetry (SWAP) and green-on-yellow perimetry (GYP) among patients with and without nuclear sclerosis among glaucoma suspects. Methods: After ophthalmic examination, patients were subjected to two perimetric tests: BYP and GYP. The visual field (VF) parameters were compared between the two perimeters ( p < 0.05 was considered significant). Results: Fifty-five eyes of 39 patients with a mean age of 60.53 ± 9.70 years were included in the study. Twenty-one eyes had clear lens or pseudophakia. Twenty-six eyes had lower grades of nuclear sclerosis (NO2NC2, NO3NC3) and eight eyes had higher grades of cataract (NO4NC4, NO5NC5). The mean retinal sensitivity (RS) in BYP was 22.08 ± 5.02 (dB) and in GYP was 23.84 ± 5.50 (dB) ( p = 0.08). The mean defect in BYP was -2.56 ± 4.40 (dB) and in GYP was -3.24 ± 5.05 (dB), pattern standard deviation (PSD) in BYP was 3.65 ± 1.91 (dB) and in GYP was 3.83 ± 1.99 (dB), and foveal threshold (FT) was 24.20 ± 4.32 (dB) in BYP and 28.10 ± 4.50 (dB) in GYP. The two perimeters showed good agreement by the Bland–Altman plot for all parameters. Fourteen eyes showed perimetric changes suggestive of glaucoma by BYP. In these, GYP had a sensitivity of 92.86% (95% CI of 66.13% to 99.82%) and specificity of 95.12% (95% CI of 83.47% to 99.40%). Conclusion: BYP and GYP show good agreement. They are comparable in clear media as well as in different grades of nuclear sclerosis. GYP showed good sensitivity and specificity compared to BYP.

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PERG and spectral sensitivity in ocular hypertensive and chronic open-angle glaucoma patients

Cited by 11 publications

References 21 publications

The contrast characteristic of the pattern electroretinogram depends on temporal frequency

The contrast characteristic of the pattern electroretinogram depends on temporal frequency

Integrated electrophysiological evaluation in early normal-tension glaucoma

Comparing retinal sensitivities on blue-on-yellow and green-on-yellow perimetry in glaucoma suspects

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