Perfusion of the Canine Esophagus with Secretions of the Upper Gastro-intestinal Tract

Redo, S. Frank; Barnes, William A.; Sierra, Andrew

doi:10.1097/00000658-195904000-00017

Cited by 49 publications

(15 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cross et al, 32 in 1951, used an external esophageal perfusion approach with bile and/or pancreatic secretions for the first time and successfully developed esophagitis. These results were confirmed by Redo, 33 while conducting similar canine experiments. Recently Li et al, 34 in an intention to study the effect of pure acid and pure bile induced esophageal injury, utilized a novel exogenous esophageal perfusion model.…”

Section: Controlled Reflux Modelssupporting

confidence: 74%

Animal Models of Barrett's Esophagus and Esophageal Adenocarcinoma–Past, Present, and Future

Kapoor

Lohani

Lee

et al. 2015

Clinical Translational Sci

View full text Add to dashboard Cite

Esophageal adenocarcinoma is the fastest rising cancer in the United States. It develops from long-standing gastroesophageal reflux disease which affects >20% of the general population. It carries a very poor prognosis with five-year survival <20%. The disease is known to sequentially progress from reflux esophagitis to a metaplastic precursor, Barrett's esophagus and then onto dysplasia and esophageal adenocarcinoma. However, only few patients with reflux develop Barrett's esophagus and only a minority of these turn malignant. The reason for this heterogeneity in clinical progression is unknown. To improve patient management, molecular changes which facilitate disease progression must be identified. Animal models can provide a comprehensive functional and anatomic platform for such a study. Rats and mice have been the most widely studied but disease homology with humans has been questioned. No animal model naturally simulates the inflammation to adenocarcinoma progression as in humans, with all models requiring surgical bypass or destruction of existing antireflux mechanisms. Valuable properties of individual models could be utilized to holistically evaluate disease progression. In this review article, we critically examined the current animal models of Barrett's esophagus, their differences and homologies with human disease and how they have shaped our current understanding of Barrett's carcinogenesis.

show abstract

Section: Controlled Reflux Modelssupporting

confidence: 74%

Animal Models of Barrett's Esophagus and Esophageal Adenocarcinoma–Past, Present, and Future

Kapoor

Lohani

Lee

et al. 2015

Clinical Translational Sci

View full text Add to dashboard Cite

show abstract

“…Cross showed in 1951 32 that direct esophageal perfusion with bile and/or pancreatic juice can induce esophagitis. These results were confirmed by Redo, who used various components within gastric juice to further study esophageal perfusion in experiments with dogs 38 …”

Section: Gastroesophageal Reflux and Experimental Reflux Esophagitissupporting

confidence: 54%

Reflux injury of esophageal mucosa: experimental studies in animal models of esophagitis, Barrett’s esophagus and esophageal adenocarcinoma

Martin

2007

Diseases of the Esophagus

View full text Add to dashboard Cite

Barrett's esophagus (BE), a gastroesophageal reflux associated complication, is defined as the replacement of normal esophageal squamous mucosa by specialized intestinal columnar mucosa with the appearance of goblet cells. The presence of BE is associated with an increased risk of developing esophageal adenocarcinoma (EAC). Although the exposure of gastroduodenal contents to the esophageal mucosa is considered to be an important risk factor for the development of esophagitis, BE and EAC, the mechanisms of reflux esophageal injury are not fully understood. Animal models are now being used extensively to identify the mechanisms of damage and to devise protective and mitigating strategies. Experimental studies on animal models by mimicking the processing of gastroesophageal reflux injury have bloomed during the past decades, however, there is controversy regarding which experimental model for reflux esophagitis, experimental BE and experimental EAC is best. In this review article we aim to clarify the basic understanding of gastroesophageal reflux injury and its complications of BE and EAC, as well as to present current understanding of the reflux experimental models. The animal models of experimental esophageal injury are summarized with focus on the surgical procedures to guide the investigator in choosing or developing a correct animal model in future studies. In addition, our own experimental studies of the animal models are also briefly discussed.

show abstract

“…These agents are certainly capable of producing a severe inflammatory reaction in the oesophagus, both in animals (Cross and Wangensteen, 1951;Redo, Barnes, and De La Sierra, 1959) and in man (McKeown, 1958;Cox, 1961;Holt and Large, 1961). Whether the oesophagus is ever exposed to appreciaible bile or alkaline reflux after resection is unknown but it seems unlikely.…”

Section: Discussionmentioning

confidence: 99%

Late results of oesophageal and oesophagogastric resection in the treatment of oesophageal cancer

1971

Thorax

View full text Add to dashboard Cite

show abstract

Perfusion of the Canine Esophagus with Secretions of the Upper Gastro-intestinal Tract

Cited by 49 publications

References 3 publications

Animal Models of Barrett's Esophagus and Esophageal Adenocarcinoma–Past, Present, and Future

Animal Models of Barrett's Esophagus and Esophageal Adenocarcinoma–Past, Present, and Future

Reflux injury of esophageal mucosa: experimental studies in animal models of esophagitis, Barrett’s esophagus and esophageal adenocarcinoma

Late results of oesophageal and oesophagogastric resection in the treatment of oesophageal cancer

Contact Info

Product

Resources

About