Perfusion MR Imaging of Brain Neoplasms

Wong, Jeffrey; Provenzale, James M.; Petrella, Jeffrey R.

doi:10.2214/ajr.174.4.1741147

Cited by 87 publications

(52 citation statements)

References 8 publications

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“…However, preloading doses are also impractical in routine in clinical practice [3]. A fourth approach is limited integration, where the computation of CBV is altered by excluding the portion of the curve above baseline, which has been used with some success in practice [6]. Nonetheless, this method still underestimates CBV, since leakage of contrast material will occur during the early phase of the injection before the signal reaches baseline.…”

Section: Techniques and Methodsmentioning

confidence: 99%

“…This can in turn help guide stereotactic biopsy, by directing the surgeon to the most aggressive portions of the tumor [1,2]. MR perfusion also holds promise in providing a better delineation of tumor margins than conventional techniques, which can similarly assist in surgical and radiation planning [5,6]. MR perfusion is also useful in the follow-up of brain tumor patients by allowing differentiation between radiation effects and recurrent tumor [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Dynamic Magnetic Resonance Perfusion Imaging of Brain Tumors

Covarrubias¹,

Rosen

Lev³

2004

The Oncologist

194

111

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In this paper, we review the technique of contrastenhanced magnetic resonance (MR) perfusion imaging of brain neoplasms, with an emphasis on its clinical applications and utility. We start with a discussion of MR perfusion techniques available today and their relative merits and shortcomings. Next, the ability of MR perfusion to provide a preoperative assessment of tumor histology is examined. We also discuss the role of MR perfusion in helping guide tumor biopsy, and its advantages over more conventional methods. We will scrutinize the use of MR perfusion for assessing true lesion extent, in contrast to conventional MR imaging and other MR techniques. We will discuss the role of MR perfusion in differentiating treatment effects, such as radiation necrosis, from tumor recurrence. Finally, the future potential applications of this technology in the setting of novel antiangiogenic therapies for brain tumors will be addressed. The Oncologist 2004;9:528-537

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Section: Techniques and Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dynamic Magnetic Resonance Perfusion Imaging of Brain Tumors

Covarrubias¹,

Rosen

Lev³

2004

The Oncologist

194

111

View full text Add to dashboard Cite

show abstract

“…[41][42][43][44] The increasing number of publications reporting a correlation between hemodynamic parameters and histologic measurements of angiogenesis, such as microvessel density, validate the use of PCT as a marker of angiogenesis. [41][42][43][44][45] Perfusion imaging of brain tumors, which has mostly used various MR perfusion techniques, can also be used for stereotactic biopsy guidance, 11 better delineation of tumor margins, 9,38 and also for assessing treatment response. 15,46 PCT shares the advantages of MR perfusion and potentially has advantages over MR perfusion because of easy accessibility, measurement of absolute perfusion values, and relatively easy postprocessing.…”

Section: 35-38mentioning

confidence: 99%

“…5,6 Because vascular proliferation is an important characteristic in the grading of astrocytomas, 7 imaging techniques that provide hemodynamic information about the tumor may help in characterizing glioma malignancy, which may overcome some of the limitations of histopathologic sampling error and conventional MR imaging. Perfusion imaging has been useful in grading cerebral neoplasms [8][9][10][11][12][13][14] and may provide reliable information on tumor physiology such as microvascularity, angiogenesis, micronecrosis, and cellularity.…”

mentioning

confidence: 99%

Role of Perfusion CT in Glioma Grading and Comparison with Conventional MR Imaging Features

Ellika

Jain²,

Patel³

et al. 2007

American Journal of Neuroradiology

117

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“…In addition, these techniques are rather insensitive for discriminating tumoral lesions from postoperative abnormal pathologic tissue or necrosis after radiotherapy. This problem, which affects morbidity, has been addressed by special methods such as 18F-fluorodeoxyglucose positron emission tomography (PET), and functional MRI (fMRI) procedures such as MR spectroscopy (MRS), diffusion-weighted imaging (DWI), and PWI (3)(4)(5). PET can provide preoperative information of tumor vascularity; however, the spatial resolution is inadequate and the technique is insensitive for demonstrating small lesions (6).…”

mentioning

confidence: 99%

Evaluation of different cerebral mass lesions by perfusion‐weighted MR imaging

Hakyemez

Erdoğan

Bolca

et al. 2006

Magnetic Resonance Imaging

192

109

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Purpose:To investigate the contribution of perfusionweighted MR imaging (PWI) by using the relative cerebral blood volume (rCBV) ratio in the differential diagnosis of various intracranial space-occupying lesions. Materials and Methods:This study involved 105 patients with lesions (high-grade glioma (N ϭ 26), low-grade glioma (Nϭ 11), meningioma (N ϭ 23), metastasis (N ϭ 25), hemangioblastoma (N ϭ 6), pyogenic abscess (N ϭ 4), schwannoma (N ϭ 5), and lymphoma (N ϭ 5)). The patients were examined with a T2*-weighted (T2*W) gradient-echo singleshot EPI sequence. The rCBV ratios of the lesions were obtained by dividing the values obtained from the normal white matter. Statistical analysis was performed with the Mann-Whitney U-test. A P-value less than 0.05 was considered statistically significant. Results:The rCBV ratio was 5.76 Ϯ 3.35 in high-grade gliomas, 1.69 Ϯ 0.51 in low-grade gliomas, 8.02 Ϯ 3.89 in meningiomas, 5.27 Ϯ 3.22 in metastases, 11.36 Ϯ 4.41 in hemangioblastomas, 0.76 Ϯ 0.12 in abscesses, 1.10 Ϯ 0.32 in lymphomas, and 3.23 Ϯ 0.81 in schwannomas. The rCBV ratios were used to discriminate between 1) high-and low-grade gliomas (P Ͻ 0.001), 2) hemangioblastomas and metastases (PϽ 0.05), 3) abscesses from high-grade gliomas and metastases (P Ͻ 0.001), 4) schwannomas and meningiomas (P Ͻ 0.001), 5) lymphomas from high-grade gliomas and metastases (P Ͻ 0.001), and 6) typical meningiomas and atypical meningiomas (P Ͻ 0.01).Conclusion: rCBV ratios can help discriminate intracranial space-occupying lesions by demonstrating lesion vascularity. It is possible to discriminate between 1) high-and low-grade gliomas, 2) hemangioblastomas and other intracranial posterior fossa masses, 3) abscesses from highgrade gliomas and metastases, 4) schwannomas and meningiomas, 5) lymphomas and high-grade gliomas and metastases, and 6) typical and atypical meningiomas.

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Perfusion MR Imaging of Brain Neoplasms

Cited by 87 publications

References 8 publications

Dynamic Magnetic Resonance Perfusion Imaging of Brain Tumors

Dynamic Magnetic Resonance Perfusion Imaging of Brain Tumors

Role of Perfusion CT in Glioma Grading and Comparison with Conventional MR Imaging Features

Evaluation of different cerebral mass lesions by perfusion‐weighted MR imaging

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