“…Taking just two of the manuscripts in this issue, sepsis and traumatic brain injury, one quickly realizes that emergency medicine is in the center and on the front lines of the biggest topics and challenges in medicine. We are forced to develop "diagnostic and therapeutic algorithm for the hypoperfused patient with septic shock in the emergency department" and do not simply borrow from other specialists who treat such patients [5]. Many patients with hyperkalemia are saved or lost in the emergency department and we study "Predictors of Outcome in Patients Presenting with Moderate to Severe Hyperkalemia" [6].…”