Perfusion measured by laser speckle contrast imaging as a predictor for expansion of psoriasis lesions

Schaap, M.; Chizari, Ata; Knop, Tom; Groenewoud, Hans; Erp, P.E.J. van; Jong, E.M.G.J. de; Steenbergen, Wiendelt; Seyger, M.M.B.

doi:10.1111/srt.13098

Cited by 11 publications

(12 citation statements)

References 31 publications

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“…Atherosclerosis, high blood pressure, heart disease, Diabetes Mellitus, and kidney failure have been studied by LDF or LSCI ( 44 ). Some diseases have been studied by many methods, for example Systemic Sclerosis by NVC ( 37 ), Laser Doppler Flowmetry ( 45 ) and LSCI ( 46 ) or psoriasis by NVC ( 38 , 39 ) and LSCI ( 47 ).…”

Section: Tissue Perfusion and Blood Flow Analysismentioning

confidence: 99%

Non-invasive techniques to access in vivo the skin microcirculation in patients

Bottino

2023

Front. Med.

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The microcirculation is composed of blood vessels with mean internal diameter smaller than 100 μm. This structure is responsible for survival of cells and in the last 50 years its study has become increasingly interesting because it often participates in the pathophysiology of several diseases or can determine better or worse prognosis for them. Due to the growing importance of knowing more about the microcirculation, several techniques have been developed and now it is possible to study its structure or function. In the last 25 years, the cutaneous microcirculation has emerged as an accessible and representative portion of generalized vascular bed allowing the examination of mechanisms of microcirculatory function and dysfunction. This mini review presents several techniques used for non-invasive access to skin microcirculation, such as Nailfold Videocapillaroscopy, Orthogonal Polarization Spectral Imaging, Sidestream Dark Field Imaging, Incident Dark field Illumination, Laser Doppler Flowmetry, and Laser Speckle Contrast Imaging applied. The techniques presented will describe which types of variables (structural or functional) can be evaluated, their limitations and potential uses.

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Section: Tissue Perfusion and Blood Flow Analysismentioning

confidence: 99%

Non-invasive techniques to access in vivo the skin microcirculation in patients

Bottino

2023

Front. Med.

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“…Our recently developed handheld perfusion imager (HAPI), yet mounted on a tripod, showed a promising potential to predict expansion of psoriasis lesions [18]. In a recent study operated on psoriasis lesions, we accomplished fairly similar pairs of mounted/handheld perfusion maps on a visual basis although a significant difference was observed between averaged lesion perfusions of the mounted/handheld pairs [19].…”

Section: Introductionmentioning

confidence: 99%

Reliability of handheld laser speckle contrast perfusion imaging demonstrated in psoriasis lesions

Chizari¹,

Schaap

Knop

et al. 2022

Photonics in Dermatology and Plastic Surgery 2022

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We assessed the reliability of handheld laser speckle contrast perfusion imaging by evaluating mounted/handheld measurement pairs operated on psoriasis lesions in three steps. First, we made a denoised perfusion map per measurement based on spatial alignment of raw speckle frames and temporal averaging of perfusion frames. Second, we used the measured on-surface speed information to compensate the movement-induced perfusion by extrapolation of the local perfusion values to the value corresponds to zero on-surface speed. Third, we compared mounted/handheld measurement pairs based on perfusion inhomogeneity and increased perilesional perfusion criteria independent of the movement artefact compensation mentioned in the second step. We conclude that after proper post-processing, handheld LSCI measurements can be as reliable as mounted measurements in terms of geometrical distorting, but with challenges to be overcome for correcting perfusion values.

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“…Since the first introduction of LSCI in 1980s 1 , it is still an active field of study and becomes advanced in different aspects. Recently, LSCI has been employed in a wide range of medical applications including ophthalmology 2 , brain 3 , robot-assisted surgery 4 , psoriasis 5,6 and plastic surgery 7 .…”

Section: Introductionmentioning

confidence: 99%

Modelling movement artefacts in handheld laser speckle contrast imaging

Chizari¹,

Tsong²,

Knop³

et al. 2023

Dynamics and Fluctuations in Biomedical Photonics XX

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Progress has been made in laser speckle contrast imaging (LSCI) of microcirculatory blood flow for biology and medicine. However, the underlying reason for occurrence of movement artefacts (MA) that compromises effective use of LSCI remains largely unexplored. Here, employing a dual-camera setup for both speckle imaging and movement tracking, we validate our analytical model that is based on optical Doppler effect for predication of speckle contrast drop as a function of applied translational speed. We perform both motorized and handheld experiments where planar and scrambled wave illumination schemes have been examined. Experimental data points fairly match the theoretical predictions. These findings indicate that the vision-based movement detection during handheld LSCI is a preferable option. Moreover, the proposed analytical model is promising for further exploration of MA in order to realize a reliable handheld LSCI.

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Perfusion measured by laser speckle contrast imaging as a predictor for expansion of psoriasis lesions

Cited by 11 publications

References 31 publications

Non-invasive techniques to access in vivo the skin microcirculation in patients

Non-invasive techniques to access in vivo the skin microcirculation in patients

Reliability of handheld laser speckle contrast perfusion imaging demonstrated in psoriasis lesions

Modelling movement artefacts in handheld laser speckle contrast imaging

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