Perfusion CT: A biomarker for soft tissue tumors of extremities

ElMaadawy, Merit; Elsorougy, Lamiaa; Razek, Ahmed Abdel Khalek Abdel; Soliman, Mosad; Soliman, Nermine Yehia

doi:10.1016/j.ejrnm.2013.05.010

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…In STS, primary tumors, local recurrences, and distant metastases appear to be well vascularized, sometimes even more so than the surrounding normal tissues [ 44 , 45 ]. Moreover, the distribution of (small) blood vessels in the tumor tissue appears to be quite homogeneous [ 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

High Prevalence of 5T4/Trophoblast Glycoprotein in Soft Tissue Sarcomas

Groothuis¹,

Penel

Italiano

et al. 2021

Cancers

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The expression of 5T4/trophoblast glycoprotein was evaluated in several histological subtypes of soft tissue sarcoma (STS) to determine whether the prevalence and level of expression of this membrane-associated glycoprotein is sufficient for use in targeted therapies. Tumor tissue microarrays containing cores from different histological subtypes of STS were stained using a standardized immunohistochemical staining method to detect 5T4; the level of staining was assessed using a semi-quantitative scoring method. No 5T4 staining was seen in the angiosarcomas and liposarcomas investigated in this study. 5T4 staining in the other STS subtypes was seen in more than 50% of cases, warranting further investigation into whether this antigen could evoke an anti-tumor immune response or can be used as target for the delivery of more potent toxins through antibody drug conjugates.

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Section: Discussionmentioning

confidence: 99%

High Prevalence of 5T4/Trophoblast Glycoprotein in Soft Tissue Sarcomas

Groothuis¹,

Penel

Italiano

et al. 2021

Cancers

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“…M. ElMaadawy и соавт. [44] провели перфузионную КТ 31 больному с опухолями мягких тканей. Авторы отметили, что метод позволяет проще выявлять опухоль и лучше отграничивать ее от окружающих тканей.…”

Section: применение динамической и перфузионной кт в клинической пракunclassified

Dynamic and perfusion computed tomography for solitary lung foci

Silantieva¹,

Petrosian²,

Агабабян³

et al. 2017

Onkol. Z. im. P.A. Gercena

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Медицинский радиологический научный центр им. А.Ф. Цыба (дир.-проф. В.Н. Галкин)-филиал ФГБУ «Национальный медицинский исследовательский радиологический центр» Минздрава России (дир.-академик РАН А.Д. Каприн), Обнинск, Россия В обзоре приведены данные литературы о применении компьютерной томографии (КТ) с использованием методик контрастного усиления. Рассмотрены методы динамической и перфузионной КТ при диагностике одиночных очагов легких, их возможности и ограничения, а также перспективы применения.

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“…In terms of medical imaging, computed tomography perfusion imaging (CTPI), magnetic resonance imaging (MRI), and digital subtraction angiography (DSA) have been widely used for evaluating IRI in myocardium and brain tissue [5–8]. CTPI is one of the most widely used techniques for detecting and evaluating perfusion in tissues or organs [9]. The advantages of CTPI include its widespread availability, short acquisition times, and simple calculation for perfusion quantification.…”

Section: Introductionmentioning

confidence: 99%

Perfusion imaging with 320-slice spiral computed tomography and color-coded digital subtraction angiography for assessing acute skeletal muscle ischemia-reperfusion injury in a rabbit model

Liu

You³

et al. 2019

BMC Med Imaging

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Background In recent years, skeletal muscle-related ischemia-reperfusion injury (IRI) has become more common. IRI can lead to severe limb injuries, multiple organ failure, and even death in some cases. However, there is still a lack of rapid and sensitive detection methods for IRI in skeletal muscle. This study aims to explore the value of computed tomography perfusion imaging (CTPI) and color-coded digital subtraction angiography (DSA) in assessing acute IRI of skeletal muscle in a rabbit model. Methods Fifty New Zealand white rabbits were randomly assigned to the ischemia-reperfusion (IR) group ( n = 40) or sham group ( n = 10). After 3 h of surgically-induced hindlimb ischemia, the IR group underwent reperfusion and CTPI and color-coded DSA were taken to assess the skeletal muscle at 0, 6, 12, or 24 h post-reperfusion. The data from CTPI and DSA in the right and left hindlimbs, blood flow (AF-R/L), blood volume (BV-R/L), contrast clearance rate (C-R/L) and the maximum contrast enhancement values (peak-R/L) were obtained. Serum superoxide dismutase (SOD), creatine kinase (CK), lactic dehydrogenase (LDH) and malondialdehyde (MDA) were measured. The statistical correlation between the above parameters (CTPI, color-coded DSA, and biochemical markers) was analyzed. Results The mean value of AF-R/L, BV-R/L, C-R/L and peak-R/L decreased linearly from 1.07 ± 0.08 to 0.75 ± 0.11, 1.03 ± 0.06 to 0.85 ± 0.14, 0.93 ± 0.15 to 0.71 ± 0.18, and 1.07 ± 0.01 to 0.47 ± 0.04, respectively. The correlation coefficients between AF-R/L and SOD, CK, LDH and MDA were 0.57, − 0.44, − 0.60, and − 0.62, respectively ( p < 0.001). The correlation coefficients between Peak-R/L and SOD, CK, LDH, MDA were 0.59, 0.68, 0.71 and 0.66, respectively ( p < 0.001). The correlation coefficient between AF-R/L and Peak-R/L was 0.70 ( p < 0.001). Conclusion Both CTPI and color-coded DSA could dynamically assess skeletal muscle IRI in rabbits.

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Perfusion CT: A biomarker for soft tissue tumors of extremities

Cited by 4 publications

References 35 publications

High Prevalence of 5T4/Trophoblast Glycoprotein in Soft Tissue Sarcomas

High Prevalence of 5T4/Trophoblast Glycoprotein in Soft Tissue Sarcomas

Dynamic and perfusion computed tomography for solitary lung foci

Perfusion imaging with 320-slice spiral computed tomography and color-coded digital subtraction angiography for assessing acute skeletal muscle ischemia-reperfusion injury in a rabbit model

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