Perfusion computed tomography evaluation of angiogenesis in liver cancer

Yang, Han Feng; Du, Yuchen; Ni, Jia; Xiang, Zhou; Li, Jin Dong; Zhang, Qing; Xu, Xiaoxue; Li, Yang

doi:10.1007/s00330-009-1693-y

Cited by 41 publications

(30 citation statements)

References 21 publications

(27 reference statements)

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“…For PS, sensitivity was 71.4% and specificity was 57.1% if the cut-off point was set at 7.31 mL/min/100 g. The possible reason was that chemotherapeutics might be prone to pass the incomplete vessel of the tumour and to play an antitumoural role if PS was high. In the meantime, new tumour vessels were augmented, the richness of the tumour vessels increased, and thus the oxygenation status of the tumour was high, which led to good response to synchronous radiochemotherapy in the early phase [29,30]. The results of our study were inconsistent with the result acquired by Wang et al [2] who demonstrated that there was no significant difference in baseline PS between responders and non-responders, and that the tumour with a high PS had a short median overall survival period.…”

Section: Discussionmentioning

confidence: 99%

The value of perfusion CT in predicting the short-term response to synchronous radiochemotherapy for cervical squamous cancer

Fan

Zhu

et al. 2011

Eur Radiol

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Section: Discussionmentioning

confidence: 99%

The value of perfusion CT in predicting the short-term response to synchronous radiochemotherapy for cervical squamous cancer

Fan

Zhu

et al. 2011

Eur Radiol

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“…Moderately differentiated and poorly differentiated HCCs are usually considered to be hypervascular, while well-differentiated tumors can be hypovascular (27). Some authors found that there was no significant difference in perfusion parameters between well to moderately differentiated and poorly differentiated HCC (22,28). However Sahani et al (24) observed that the perfusion of well-differentiated HCC was distinct from those of moderately and poorly differentiated HCC.…”

Section: Perfusion Imaging For Detection Of Hepatocellular Carcinomamentioning

confidence: 99%

Perfusion CT imaging of the liver: review of clinical applications

Oğul

Kantarcı²,

Genç³

et al. 2014

Diagn Interv Radiol

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Perfusion computed tomography (CT) has a great potential for determining hepatic and portal blood flow; it offers the advantages of quantitative determination of lesion hemodynamics, distinguishing malignant and benign processes, as well as providing morphological data. Many studies have reported the use of this method in the assessment of hepatic tumors, hepatic fibrosis associated with chronic liver disease, treatment response following radiotherapy and chemotherapy, and hepatic perfusion changes after radiological or surgical interventions. The main goal of liver perfusion imaging is to improve the accuracy in the characterization of liver disorders. In this study, we reviewed the clinical application of perfusion CT in various hepatic diseases. The advent of multidetector CT has given rise to the acquisition of images with higher quality and accuracy. Multidetector CT has been developed as a noninvasive imaging modality for evaluation of vascular anatomy. It has also made it possible to perform CT angiography of the hepatic vessels. New generation CT systems with multidetector are capable of performing volumetric imaging. These systems provide a single rotational acquisition and almost the whole upper abdomen can be appraised by means of serial rotational acquisitions at a single location in the z-direction. Multidetector CT imaging is used extensively for the preoperative selection of living related liver donors, as well as evaluation of the vascular anatomy of the recipients (1). This imaging technique is also used for the initial evaluation and follow-up of most patients with hepatic metastases, providing valuable information about the number, size, and distribution of hepatic metastases and the presence and extent of extrahepatic disease (1).Perfusion CT imaging permits the qualitative and quantitative assessment of liver perfusion. In perfusion CT, a quantitative tissue perfusion map is obtained from dynamic CT data and displayed using a color scale permitting the quantification of tissue perfusion in absolute units at high spatial resolution (2). Perfusion CT efficiently locates abnormal tissue perfusion which is difficult to detect accurately with conventional CT (3). Functional assessment of the perfusion of normal and pathologic tissues is performed by means of quantitative or semiquantitative parameters, such as blood flow (BF), blood volume (BV), mean transit time (MTT), portal liver perfusion (PLP), arterial liver perfusion (ALP) and hepatic perfusion index (HPI). Perfusion CT measures the temporal changes in tissue density through a series of dynamically acquired CT images after intravenous injection of an iodinated contrast material (4, 5). Perfusion CT may be performed quickly and provide valuable data for diagnosis. However, there are some limitations of this method such as long breath-holding for portal flow measurement, separation of arterial and portal blood flow, additional radiation exposure, limited craniocaudal scan range, and standardization of analytic methods (2). In this a...

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“…A suitable biomarker may increase the probability of detecting a true antitumor effect, as well as predict clinical activity after treatment in a short course. Computed tomography (CT) imagingbased therapy monitoring has gained an important role in oncologic imaging [9][10][11]. Tumour size change in conventional CT has been widely used to assess antitumor response [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

CT spectral imaging for monitoring the therapeutic efficacy of VEGF receptor kinase inhibitor AG-013736 in rabbit VX2 liver tumours

Liu

Yan

et al. 2016

Eur Radiol

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Perfusion computed tomography evaluation of angiogenesis in liver cancer

Abstract: CT perfusion imaging can quantitatively assess the blood supply and its distribution in liver cancer. TBF or HAP may be a useful parameter in assessing angiogenesis of liver cancer.

Cited by 41 publications

References 21 publications

The value of perfusion CT in predicting the short-term response to synchronous radiochemotherapy for cervical squamous cancer

The value of perfusion CT in predicting the short-term response to synchronous radiochemotherapy for cervical squamous cancer

Perfusion CT imaging of the liver: review of clinical applications

CT spectral imaging for monitoring the therapeutic efficacy of VEGF receptor kinase inhibitor AG-013736 in rabbit VX2 liver tumours

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