Perfusion- and pattern-based quantitative CT indexes using contrast-enhanced dual-energy computed tomography in diffuse interstitial lung disease: relationships with physiologic impairment and prediction of prognosis

Moon, Jung Won; Bae, Jang Pyo; Lee, Ho Yun; Kim, Namkug; Chung, Man Pyo; Park, Hye Yun; Chang, Yongjun; Seo, Joon Beom; Lee, Kyung Soo

doi:10.1007/s00330-015-3946-2

Cited by 29 publications

(24 citation statements)

References 20 publications

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“…FVC (mean 75.74) has mild reduction indicating restrictive lung diseases, which agrees with Moon et al and Jacob et al, with FVC mean 76.5 ± 18.2, 71% respectively [3,31].…”

Section: Discussionsupporting

confidence: 89%

“…Normal lung was significantly correlated with FVC% (r = 0.455, p value = 0.011), FEV1% (r = 0.691, p value = < 0.001), FEV1/FVC% (r = 0.753, p value = < 0.001) that is matching with Moon's study which showed a very strong positive correlation with functional lung volume and FVC% (r = 0.72, p < 0.01) [31]. Shin et al's study also agreed with our study, which showed a high positive correlation with FLV and a high positive correlation with FVC and FEV1 (r = 0.80 and 0.73, p < 0.01) [21].…”

Section: Discussionsupporting

confidence: 86%

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Visual and quantitative assessment of HRCT pulmonary changes in idiopathic interstitial pneumonia with PFT correlation

Kolta

Goneimy

2020

Egypt J Radiol Nucl Med

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Background: Our study was designed to correlate the degree of parenchymal affection in idiopathic interstitial pneumonia using visual and semi-quantitative HRCT assessment with pulmonary function test results. The study involved 50 patients diagnosed as idiopathic interstitial pneumonia. They were referred from a chest outpatient clinic to the Radiology Department in the Faculty of Medicine, Cairo University for HRCT assessment in the period from January 2017 to March 2019. Variable lung parenchymal affection was studied using HRCT and variable post acquisition processing (multi-planar reconstruction, volumetric assessment, 3D color-coded images). Results: Usual interstitial pneumonia was the most common type of IP, found in approximately 40 patients (80% of cases) followed by nonspecific interstitial pneumonia found in 5 patients (10% of cases) and lymphocytic interstitial pneumonia found in 3 patients (6% of cases), and desquamative interstitial pneumonia was the least common type of IP, found only in 2 patients (4% of cases).Honeycombing was significantly correlated with FVC%, FEV1%, and FEV1/FVC% (p = 0.013, p = <0.001, p = 0.002 respectively). Also, reticular was significantly correlated with FVC% (p = 0.041). Conclusion: Semi-quantitative image analysis, including the use of machine learning, provides a great deal of promise in the ILD field; such methods may be used together with visual analysis to obtain the most accurate diagnostic and prognostic information. Summary/keywords: HRCT is most sensitive in the detection of ILD than chest radiography or conventional chest computed tomography (CT). Advances in HRCT scanning and interpretation have facilitated and improved accuracy for use in diagnosing idiopathic pulmonary fibrosis (IPF), eliminating the need for a surgical biopsy in many patients. Consequently, HRCT scans became sufficient to allow a confident IPF diagnosis It is important to note that there are potential differences in interpretation of HRCT patterns between thoracic radiologists. However, these differences seem to be in general within a clinically acceptable range of observer variation and can be partially mitigated by review of difficult cases at ILD referral centers. Semi-quantitative CT assessment is increasingly being used in ILD to identify pulmonary abnormalities and diagnose specific ILDs; recent studies showed that outcomes of computer-assisted imaging can be correlated with lung function tests and degree of dyspnea and functional disability This study was designed to correlate the degree of parenchymal affection in IP using visual and semi-quantitative HRCT assessment with PFT results. Semi-quantitative imaging, including color-coded images (HU related), is a new and promising approach in the field of ILD diagnosis and prognosis.

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“…FVC (mean 75.74) has mild reduction indicating restrictive lung diseases, which agrees with Moon et al and Jacob et al, with FVC mean 76.5 ± 18.2, 71% respectively [3,31].…”

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 86%

Visual and quantitative assessment of HRCT pulmonary changes in idiopathic interstitial pneumonia with PFT correlation

Kolta

Goneimy

2020

Egypt J Radiol Nucl Med

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“…ILAs were defined as particular patterns of increased lung density, including ground-glass or reticular abnormalities, diffuse centrilobular nodularity, nonemphysematous cysts, and honeycombing or traction bronchiectasis, affecting more than 5% of any lung zone [21]. ILAs were assessed subjectively by adding and scoring the overall extent of fibrosis-related lung parenchymal abnormalities, which were estimated from the nearest 5% of parenchymal involvement to the whole lung volume (100%) [22,23]. We used an in-house computer software to assess and automatically calculate the emphysema index, which was defined as the volume fraction of the lung below − 950 HU [23,24].…”

Section: Ct Findingsmentioning

confidence: 99%

Prevalence of and risk factors for pulmonary complications after curative resection in otherwise healthy elderly patients with early stage lung cancer

Park

Shin

et al. 2019

Respir Res

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Background and objective: The prevalence of lung cancer has been increasing in healthy elderly patients with preserved pulmonary function and without underlying lung diseases. We aimed to determine the prevalence of and risk factors for postoperative pulmonary complications (PPCs) in healthy elderly patients with non-small cell lung cancer (NSCLC) to select optimal candidates for surgical resection in this subpopulation. Methods: We included 488 patients older than 70 years with normal spirometry results who underwent curative resection for NSCLC (stage IA-IIB) between 2012 and 2016. Results: The median (interquartile range) age of our cohort was 73 (71-76) years. Fifty-two patients (10.7%) had PPCs. Severe PPCs like acute respiratory distress syndrome, pneumonia, and respiratory failure had prevalences of 3.7, 3.7, and 1.4%, respectively. Compared to patients without PPCs, those with PPCs were more likely to be male and current smokers; have a lower body mass index (BMI), higher American Society of Anesthesiologists (ASA) classification, more interstitial lung abnormalities (ILAs), and higher emphysema index on computed tomography (CT); and have undergone pneumonectomy or bilobectomy (all p < 0.05). On multivariate analysis, ASA classification ≥3, lower BMI, ILA, and extent of resection were independently associated with PPC risk. The short-term all-cause mortality was significantly higher in patients with PPCs. Conclusions: Curative resection for NSCLC in healthy elderly patients appeared feasible with 10% PPCs. ASA classification ≥3, lower BMI, presence of ILA on CT, and larger extent of resection are predictors of PPC development, which guide treatment decision-making in these patients.

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“…Comparison studies on the assessment of pulmonary perfusion using DECT have shown good agreement with both planar scintigraphy and SPECT/CT . The DECT approach was also successful to detect perfusion defects in the context of pulmonary embolism and parenchymal lung disease . Other single‐energy CT (SECT) techniques may also process contrast‐enhanced CT images to produce functional maps of the lung parenchyma; however, they do not quantitatively address the perfused blood volume.…”

Section: Introductionmentioning

confidence: 99%

“…16,17 The DECT approach was also successful to detect perfusion defects in the context of pulmonary embolism [18][19][20][21][22] and parenchymal lung disease. 23,24 Other single-energy CT (SECT) techniques may also process contrast-enhanced CT images to produce functional maps of the lung parenchyma; 6,25,26 however, they do not quantitatively address the perfused blood volume.…”

Section: Introductionmentioning

confidence: 99%

Assessing lung function using contrast‐enhanced dual‐energy computed tomography for potential applications in radiation therapy

et al. 2017

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Perfusion- and pattern-based quantitative CT indexes using contrast-enhanced dual-energy computed tomography in diffuse interstitial lung disease: relationships with physiologic impairment and prediction of prognosis

Cited by 29 publications

References 20 publications

Visual and quantitative assessment of HRCT pulmonary changes in idiopathic interstitial pneumonia with PFT correlation

Visual and quantitative assessment of HRCT pulmonary changes in idiopathic interstitial pneumonia with PFT correlation

Prevalence of and risk factors for pulmonary complications after curative resection in otherwise healthy elderly patients with early stage lung cancer

Assessing lung function using contrast‐enhanced dual‐energy computed tomography for potential applications in radiation therapy

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