Perfusion and Flow Extraction Product as Potential Discriminators in Untreated Follicular and Diffuse Large B Cell Lymphomas Using Volume Perfusion CT With Attempt at Histopathologic Explanation

Spira, Daniel; Adam, Patrick; Linder, Catharina Maria; Spira, Sven Michael; Pintoffl, Jan; Claussen, Claus D.; Horger, Marius

doi:10.2214/ajr.11.7858

Cited by 11 publications

(10 citation statements)

References 34 publications

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“…While observed BF values were in line with the studies from Ippolito et al (52.2 vs. 45.7 mL/100 mL/min), differences in BV (13.0 vs. 20.6 mL/100 mL) might be explained by different acquisition duration and temporal resolution [3,8,23]. Results for lymphoma patients were also comparable with previous studies from our institution [11]. So far, only a few studies have calculated iodine-related attenuation values or iodine concentrations in solid tumours or lymphoma.…”

Section: Discussionsupporting

confidence: 91%

“…This allows the calculation of quantitative perfusion parameters that represent markers for tumour characterization [8] and therapy monitoring [9]. VPCT has also been shown to provide beneficial aspects in lymphoma patients, e.g., perfusion parameters from VPCT may be used as response imaging markers for therapy monitoring [10] and for differentiation between various nonHodgkin lymphoma entities [11].…”

Section: Introductionmentioning

confidence: 99%

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Iodine concentration as a perfusion surrogate marker in oncology: Further elucidation of the underlying mechanisms using Volume Perfusion CT with 80 kVp

et al. 2015

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• Iodine concentration derived from low kVp CT is regarded as perfusion surrogate • Correlation with Perfusion CT was performed to elucidate timing and histology dependencies • Highest correlation was present 7 sec after aortic peak enhancement in hepatocellular carcinoma • In lymphoma, highest correlation was calculated 3.5 sec after aortic peak enhancement • With these results, further optimization of Dual energy CT protocols is possible.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Iodine concentration as a perfusion surrogate marker in oncology: Further elucidation of the underlying mechanisms using Volume Perfusion CT with 80 kVp

et al. 2015

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“…Most of them originate from B cells, which express the integral transmembrane protein CD20 at high levels. NHL subtypes are characterized by a distinct histopathologic anatomy and a complex and variable vascularity (1).…”

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confidence: 99%

“…Especially in radioimmunotherapy, a nonuniform distribution within tumors appears to limit efficacy (4). Therefore, attempts are being made to search for diagnostic biomarkers to predict therapeutic outcome using histopathology (5) or perfusion measurements (1).…”

mentioning

confidence: 99%

Tumor Uptake of Anti-CD20 Fabs Depends on Tumor Perfusion

et al. 2016

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Antibodies have become an established treatment modality in cancer therapy during the last decade. However, these treatments often suffer from an insufficient and heterogeneous response despite validated antigen or target receptor expression in the tumor. In fact, therapeutic success depends on both the presence of the tumor antigen and its accessibility by the antibody. In search of a suitable preclinical animal model to evaluate the mechanisms of tumor heterogeneity and hemodynamics, we characterized two exemplary non-Hodgkin lymphoma subtypes with comparable CD20 expression and metabolism, SUDHL-4 and Granta-519, using multimodal imaging techniques. Methods: To investigate in vivo biodistribution, two differently modified αCD20 antigen-binding fragments (Fab), prepared by PASylation with a 200-residue polypeptide tag comprising Pro, Ala, and Ser (PAS 200 ) and by fusion with an albumin-binding domain (ABD), were radiolabeled with 125 I and intravenously injected into immunocompromised mice bearing corresponding xenografts. Results: Validation with 18 F-FDG revealed a similar distribution in vital tumor tissue 1 h after injection. However, large differences in tumor uptake were observed when the CD20-specific radiotracers 125 I-Fab-ABD and 125 I-Fab-PAS 200 were applied (respective percentages injected dose per gram at 24 h after injection: 12.3 and 2.4 for Granta-519 vs. 5.8 and 1.2 for SUDHL-4). Three-dimensional light-sheet fluorescence microscopy with Cy5-Fab-PAS 200 confirmed better tracer extravasation in the Granta-519 tumors. Moreover, dynamic contrast-enhanced (DCE) MRI revealed significantly reduced perfusion in the SUDHL-4 tumors. Conclusion: Tracer uptake was highly dependent on local tumor perfusion and Fab permeation in the SUDHL-4 and Granta-519 tumors. Thus, the SUDHL-4 xenograft offers an excellent model for investigating the influence of therapies affecting tumor angiogenesis.

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“…As a rule, lymphomas are visualized as solid, homogeneously contrast-enhanced masses. Despite good vascularization, the perfusion parameters of lymphomas only rarely reach values comparable with those of the pancreatic parenchyma and accordingly have mildly low perfusion [39]. In the case of pancreatitis, a differentiation must be made between chronic pancreatitis and acute pancreatitis.…”

Section: Pancreatic Lymphomamentioning

confidence: 99%

The Role of Volume Perfusion CT in the Diagnosis of Pathologies of the Pancreas

Grözinger¹,

Grözinger²,

Horger³

2014

Fortschr Röntgenstr

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The review discusses the potential role of volume perfusion CT (VPCT) in the diagnosis and follow-up of different pathologies of the pancreas. VPCT enables a differentiation of different pancreatic tumors like adenocarcinoma or neuroendocrine tumors based on functional parameters like blood flow, blood volume and permeability. Furthermore, the article discusses the potential indications for VPCT imaging of inflammatory diseases of the pancreas such as acute or chronic pancreatitis and autoimmune pancreatitis. Key Points: ??VPCT may help to diagnose even small pancreatic tumors based on functional parameters ??Functional perfusion parameters can help to characterize pancreatic neoplasms ??In acute pancreatitis VPCT can evaluate the perfusion status of the organ Citation Format: ??Gr?zinger G., Gr?zinger A., Horger M. The Role of Volume Perfusion CT in the Diagnosis of Pathologies of the Pancreas. Fortschr R?ntgenstr 2014; 186: 1082???1093

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Perfusion and Flow Extraction Product as Potential Discriminators in Untreated Follicular and Diffuse Large B Cell Lymphomas Using Volume Perfusion CT With Attempt at Histopathologic Explanation

Abstract: Volume perfusion CT allows assessment of differences in vascularity of follicular and diffuse large B cell lymphomas, reflecting vascular luminal variability and histopathologic anatomy.

Cited by 11 publications

References 34 publications

Iodine concentration as a perfusion surrogate marker in oncology: Further elucidation of the underlying mechanisms using Volume Perfusion CT with 80 kVp

Iodine concentration as a perfusion surrogate marker in oncology: Further elucidation of the underlying mechanisms using Volume Perfusion CT with 80 kVp

Tumor Uptake of Anti-CD20 Fabs Depends on Tumor Perfusion

The Role of Volume Perfusion CT in the Diagnosis of Pathologies of the Pancreas

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