Perfusion and diffusion magnetic resonance imaging in human cerebral venous thrombosis

Doege, Claudia A.; Tavakolian, R.; Kerskens, Christian; Romero, B. I.; Lehmann, Rüdiger; Einhaeupl, K. M.; Villringer, Arno

doi:10.1007/s004150170133

Cited by 56 publications

(36 citation statements)

References 41 publications

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“…This might induce an energy failure and a disruption of the blood-brain barrier that results in vasogenic edema and hemorrhagic transformation from increased venous pressure. [17][18][19] The protective mechanisms against the abrupt increase of intravenous pressure have been described in the literature. One of these mechanisms is the opening of reserve capillaries that causes an increase in cerebral blood volume during the early phase of sinus occlusion.…”

Section: Discussionmentioning

confidence: 99%

Frequency and Topographic Distribution of Brain Lesions in Pediatric Cerebral Venous Thrombosis

Tekşam¹,

Moharir²,

deVeber³

et al. 2008

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 99%

Frequency and Topographic Distribution of Brain Lesions in Pediatric Cerebral Venous Thrombosis

Tekşam¹,

Moharir²,

deVeber³

et al. 2008

AJNR Am J Neuroradiol

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“…This finding accounts for the observed delayed cerebral perfusion seen with perfusionweighted MRI with prolonged transit time. 74,91,104,124,130,132,153 Direct Cerebral Venography Direct cerebral venography is performed by direct injection of contrast material into a dural sinus or cerebral vein from microcatheter insertion via the internal jugular vein. Direct cerebral venography is usually performed during endovascular therapeutic procedures.…”

Section: Cerebral Angiographymentioning

confidence: 99%

Diagnosis and Management of Cerebral Venous Thrombosis

Saposnik¹,

Barinagarrementería²,

Brown³

et al. 2011

Stroke

1,654

1,229

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Background— The purpose of this statement is to provide an overview of cerebral venous sinus thrombosis and to provide recommendations for its diagnosis, management, and treatment. The intended audience is physicians and other healthcare providers who are responsible for the diagnosis and management of patients with cerebral venous sinus thrombosis. Methods and Results— Members of the panel were appointed by the American Heart Association Stroke Council's Scientific Statement Oversight Committee and represent different areas of expertise. The panel reviewed the relevant literature with an emphasis on reports published since 1966 and used the American Heart Association levels-of-evidence grading algorithm to rate the evidence and to make recommendations. After approval of the statement by the panel, it underwent peer review and approval by the American Heart Association Science Advisory and Coordinating Committee. Conclusions— Evidence-based recommendations are provided for the diagnosis, management, and prevention of recurrence of cerebral venous thrombosis. Recommendations on the evaluation and management of cerebral venous thrombosis during pregnancy and in the pediatric population are provided. Considerations for the management of clinical complications (seizures, hydrocephalus, intracranial hypertension, and neurological deterioration) are also summarized. An algorithm for diagnosis and management of patients with cerebral venous sinus thrombosis is described.

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“…Cerebral venous and dural sinus thrombosis causes a wide spectrum of parenchymal changes, ranging from vasogenic and cytotoxic edema to intracerebral hematomas. 3,5 These complications may lead to a compartmentalized intracranial hypertension that secondarily compresses intraparenchymal veins, with a subsequent worsening of edema and swelling. Furthermore, in CVDST the regional cerebral blood flow may be reduced because of paradoxical arteriolar vasoconstriction.…”

mentioning

confidence: 99%

“…Furthermore, in CVDST the regional cerebral blood flow may be reduced because of paradoxical arteriolar vasoconstriction. 5,19 A condition that, based on experimental data, has features reminiscent of ischemic penumbra. 18 Decompressive surgery creates space for the swelling brain and, by reducing intracranial hypertension and brainstem compression, may break the vicious cycle by relieving arteriolar constriction and restoring flow in compressed venous collaterals.…”

mentioning

confidence: 99%

Decompressive surgery in malignant dural sinus thrombosis: report of 3 cases and review of the literature

Lanterna¹,

Gritti²,

Manara

et al. 2009

FOC

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Cerebral venous and dural sinus thrombosis (CVDST) is a rare cause of stroke in young and middle-aged adults. When the clinical course is complicated by uncontrollable intracranial hypertension and brainstem compression due to edema or cerebral hemorrhage, the prognosis is poor. The authors evaluated the therapeutic role of surgical decompression in patients with clinical signs of impending herniation. Cerebral venous and dural sinus thrombosis complicated by impending brain herniation a very rare, life-threatening but potentially treatable clinical condition. Three patients with pupillary signs of transtentorial herniation due to brain edema and hemorrhage caused by CVDST (superior sagittal sinus in 1 patient and transverse and sigmoid sinus in 2 patients) were treated surgically. The intervention consisted of clot removal, infarcted tissue resection, and frontotemporoparietooccipital craniectomy with duraplasty. According to the Glasgow Outcome Scale, 2 patients were classified as having good recovery and 1, moderate disability. The results of neuropsychological assessment were normal in 2 patients and demonstrated a partial neuropsychological deficit (neglect) in the other. Surgery may be indicated in selected patients with CVDST whose condition is deteriorating because of intractable intracranial hypertension and impending brain herniation.

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Perfusion and diffusion magnetic resonance imaging in human cerebral venous thrombosis

Abstract: In patients with CVT, prolongations of MTT in the absence of changes in CBV and ADC seem to indicate reversible involvement of brain tissue, a situation corresponding to the ischaemic penumbra.

Cited by 56 publications

References 41 publications

Frequency and Topographic Distribution of Brain Lesions in Pediatric Cerebral Venous Thrombosis

Frequency and Topographic Distribution of Brain Lesions in Pediatric Cerebral Venous Thrombosis

Diagnosis and Management of Cerebral Venous Thrombosis

Decompressive surgery in malignant dural sinus thrombosis: report of 3 cases and review of the literature

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