ObjectiveWe evaluated whether the preoperative serum concentration of brain
natriuretic peptide (BNP) is a predictor of in-hospital mortality in
patients that underwent cardiac surgery.MethodsWe continuously evaluated 488 patients that underwent cardiac valve surgery
or coronary artery bypass grafting (CABG) between January of 2009 and July
of 2012. Follow up of these patients were done prospectively for 30 days
postoperatively.ResultsData analysis showed that the overall mortality rate was equal to 9.6%,
Receiver Operating Charactheristic (ROC) curve analysis found the optimal
cut-off value of BNP equal to 382 pg/mL for overall mortality (AUC=0.73, 95%
CI=0.66 to 0.81, P<0.001). Multivariate analysis showed
that the value of BNP higher than 382 pg/mL (P=0.033,
HR=2.05, 95% CI=1.6 to 3.98) was an independent predictor of overall
mortality at 30 days postoperatively.ConclusionWe concluded that the preoperative serum concentration of BNP is an
independent predictor of mortality in patients undergoing valve surgery or
coronary artery bypass graft.