Performance tests of two portable mini gamma cameras for medical applications

Sánchez, F.; Fernandez, M.; Gimenez, M. V. Castillo; Benlloch, J.; Rodríguez-Álvarez, M. J.; Quirós, Fernando; Lerche, Christoph; Pavón, N.; Palazón, J A; Martínez, J.D.; Sebastiá, A.

doi:10.1118/1.2358199

Cited by 61 publications

(57 citation statements)

References 25 publications

(32 reference statements)

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“…Detection sensitivity depends on the distance from the detector to the imaging plane, being 19,135 and 1,111 cpm/MBq for distances of 3 and 15 cm, respectively. More technical details can be found in the report of Sanchez et al (6).…”

Section: Surgical Proceduresmentioning

confidence: 99%

“…However, patent blue migrates quickly and sentinel nodes in the head and neck region are less frequently stained blue (5). A recently introduced portable g-camera can detect radioactive hot spots by visualization of the tracer signal on screen (6,7). In cases of urologic tumors, this camera was able to visualize and localize sentinel nodes during operation and confirm if they had accurately been removed (8).…”

mentioning

confidence: 99%

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A Portable γ-Camera for Intraoperative Detection of Sentinel Nodes in the Head and Neck Region

Vermeeren¹,

Olmos²,

Klop³

et al. 2010

J Nucl Med

135

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We introduced and evaluated a portable g-camera for intraoperative visualization of sentinel nodes in the head and neck region. Methods: Planar lymphoscintigraphy and SPECT/CT were performed after peritumoral injection of 99m Tc-nanocolloid in 25 patients (head and neck melanoma or oral cavity carcinoma). Sentinel nodes were localized intraoperatively with a portable g-camera and a hand-held g-probe. The portable g-camera was used to determine the distribution of remaining radioactivity after excision of the sentinel nodes. Results: The portable g-camera visualized all 70 preoperatively identified sentinel nodes. Sentinel nodes at difficult sites could be localized more efficiently, and in 6 patients, 9 additional nodes (1 tumor-positive) were identified with the portable g-camera after excision. Conclusion: Intraoperative identification of sentinel nodes in the head and neck region with a portable g-camera is feasible and might lead to detection of more sentinel nodes.

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Section: Surgical Proceduresmentioning

confidence: 99%

mentioning

confidence: 99%

A Portable γ-Camera for Intraoperative Detection of Sentinel Nodes in the Head and Neck Region

Vermeeren¹,

Olmos²,

Klop³

et al. 2010

J Nucl Med

135

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“…The SPECT system utilizes a dual head detector geometry based on a gamma camera previously developed by our group. 22 The PET subsystem has been developed by the authors and was fully tested and validated in a previous study.…”

Section: System Designmentioning

confidence: 99%

“…Since our group has prior experience in the use of continuous scintillating crystals in small gamma cameras 22 we have extended the use of continuous scintillating crystals to our small animal PET and SPECT systems.…”

Section: Iintroductionmentioning

confidence: 99%

ALBIRA: A small animal PET/SPECT/CT imaging system

et al. 2013

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Abstract:Purpose: We have developed a trimodal PET/SPECT/CT scanner for small animal imaging. The gamma ray sub-systems are based on monolithic crystals coupled to multi-anode photomultiplier tubes (MA-PMTs), while CT comprises a commercially available micro-focus X-ray tube and a CsI scintillator 2D pixelated flat panel X-ray detector. In this study we will report on the design and performance evaluation of the multimodal system. Methods: X-ray transmission measurements are performed based on cone-beam geometry. Individual projections were acquired by rotating the X-ray tube and the 2D flat panel detector, thus making possible a transaxial FOV of roughly 80 mm in diameter and an axial FOV of 65 mm for the CT system. The SPECT component has a dual head detector geometry mounted on a rotating gantry. The distance between the SPECT module detectors can be varied in order to optimize specific user requirements, including variable FOV. The PET system is made up of eight compact modules forming an octagon with an axial Field Of View (FOV) of 40 mm and a transaxial FOV of 80 mm in diameter. The main CT image quality parameters (spatial resolution and uniformity) have been determined. In the case of the SPECT, the tomographic spatial resolution and system sensitivity have been evaluated with a 99m Tc solution using single-pinhole and multipinhole collimators. PET and SPECT images were reconstructed using threedimensional (3D) Maximum Likelihood and Ordered Subset Expectation Maximization (MLEM and OSEM)) algorithms developed by the authors, whereas the CT images were obtained using a 3D based FBP algorithm.Results: CT spatial resolution was 85 μm while a uniformity of 2.7% was obtained for a water filled phantom at 45 kV. The SPECT spatial resolution was better than 0.8 mm measured with a Derenzo-like phantom for a FOV of 20 mm using a 1-mm pinhole aperture collimator. The full width at half-maximum (FWHM) PET radial spatial resolution at the center of the field of view was 1.55 mm. The SPECT system sensitivity for a FOV of 20 mm and 15% energy window was 700 cps/MBq (7.8x10 -2 %) using a multi-pinhole equipped with 5 apertures 1 mm in diameter, whereas the PET absolute sensitivity was 2% for a 350-650 keV energy window and a 5 ns timing window. Several animal images are also presented. Conclusions:The new small animal PET/SPECT/CT proposed here exhibits high performance, producing high-quality images suitable for studies with small animals. Monolithic design for PET and SPECT scintillator crystals reduces cost and complexity without significant performance degradation.

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“…This support also incorporates a touchsensitive screen, which allows images to be viewed with ease throughout the surgical process. The intrinsic spatial resolution is approximately 2 mm and the energy resolution is 13% at 140 keV [6]. This PGC is provided with laser devices, which can help centre the image acquisitions, and it can also acquire images from dual isotopes.…”

mentioning

confidence: 99%

Portable gamma cameras: the real value of an additional view in the operating theatre

Duch

2011

Eur J Nucl Med Mol Imaging

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It has been a long time since the preliminary portable gamma cameras (PGCs) were developed [1]. During the last decade some PGCs have become available for clinical practice, and can be used in open surgery or with laparoscopy, providing information that can be combined with that coming from conventional or laparoscopic gamma probes. Some of these PGCs are not designed specifically for radioguided surgery (Dilon 6800 gamma camera, a model optimized to perform breast-specific gamma imaging, or Cardiotom 3D mobile gamma camera, optimized to perform myocardial perfusion scintigraphy), but other models are focused on sentinel node (SN) procedures [2][3][4].In this issue of the journal, Vidal-Sicart et al.[5] report on the use of the Sentinella S102 (Oncovision) camera, which is a compact scintillation camera with a 50×50× 4 mm 3 CsI crystal optically coupled through a light guide to a flat panel type position-sensitive photomultiplier tube. This model is connected to a computer via USB, which processes the output signals and provides energy to the detector system. It has three interchangeable pin-hole collimators with apertures of diameter 1.0, 2.5 and 4 mm, and is mounted in a support to facilitate transport to the operating theatre. This support also incorporates a touchsensitive screen, which allows images to be viewed with ease throughout the surgical process. The intrinsic spatial resolution is approximately 2 mm and the energy resolution is 13% at 140 keV [6]. This PGC is provided with laser devices, which can help centre the image acquisitions, and it can also acquire images from dual isotopes. It is able to use a pointer (i.e. of iodine-125) to help localize hot spots seen on the screen.The main application of these devices is in SN procedures. SNs are widely used in breast cancer, melanoma and head and neck cancer, but in the last decade, their use has expanded to additional indications, with more sophistication and complexity in the technique, including indications in urology, gynaecology and gastroenterology. The addition of PGCs has improved the SN technique, particularly when intraoperative tracer injection is needed or in laparoscopic SN localization [7][8][9].In breast cancer, the main indication for a SN procedure worldwide, usually no laparoscopic technique and no intraoperative tracer injection is needed. The utility of the PGC in breast cancer remains only when no conventional gamma camera is available, and in particular in cases with extra-axillary drainage. In breast cancer, the use of PGCs in radioguided occult lesion localization combined with a conventional gamma probe has been described [7].In head and neck cancers the usefulness of the PGC seems more clear, because of the unpredictable lymphatic drainage and the possibility of comparing the preoperative image and the intraoperative image in order to ensure that no SN is missed. This is made possible by PGCs as they can give an overview of all radioactive hot spots within the surgical field. Prior SPECT images may be mandatory in head and nec...

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Performance tests of two portable mini gamma cameras for medical applications

Cited by 61 publications

References 25 publications

A Portable γ-Camera for Intraoperative Detection of Sentinel Nodes in the Head and Neck Region

A Portable γ-Camera for Intraoperative Detection of Sentinel Nodes in the Head and Neck Region

ALBIRA: A small animal PET/SPECT/CT imaging system

Portable gamma cameras: the real value of an additional view in the operating theatre

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