Performance status scale for head and neck scores for oral cancer survivors: predictors and factors for improving quality of life

Kondo, Toshiyuki; Sugauchi, Akinari; Yabuno, Yusuke; Kobashi, Hironobu; Amano, Katsuhiko; Aikawa, Tomonao; Kogo, Mikihiko; Okura, Masaya

doi:10.1007/s00784-018-2587-7

Cited by 9 publications

(4 citation statements)

References 23 publications

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“…The quality of life of head and neck cancer patients is often reduced due to psychosocial problems, lower general performance status and speech, and mastication impairment following intraoral free flap reconstruction. [17][18][19][20][21][22] Our results show that, in addition to these factors, the presence of neuropathic pain at the forearm donor site significantly reduces quality of life even further, emphasizing the great need for improving neuropathic pain prevention and management. Moreover, our results show that neuropathic pain was associated with inferior hand function.…”

Section: Discussionmentioning

confidence: 92%

Neuropathic Donor-Site Pain following Radial Forearm Free Flap Harvest: A Multicenter Study on Incidence, Prognostic Factors, and Quality of Life

Bruin

Hundepool

Duraku³

et al. 2022

J Reconstr Microsurg

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Background The radial forearm free flap (RFFF) is widely used and is considered one of the workhorse flaps in oncologic head and neck reconstructions. However, the potential for significant donor-site morbidity remains a major drawback. Although various donor-site problems have been reported, the incidence of neuropathic pain and possible predicting factors remain unclear. This study aimed to identify the incidence, prognostic factors and impact on quality of life of neuropathic pain following RFFF harvest. Methods In this multicenter, cross-sectional study, 167 patients who underwent a RFFF reconstruction between 2010-2020 were included. Baseline characteristics were collected by medical charts. All patients received questionnaires to measure patient’s pain (Doleur Neuropathic 4 and VAS Pain), hand function (Patient Rated Wrist Hand Evaluation) and quality of life (EuroQol 5D). Multiple logistic regression was used to identify prognostic factors associated with outcomes. Results A total of 114 patients (68%) completed the questionnaire. Neuropathic pain was present in 18% of all patients. Donor-site wound problems, mostly tendon exposure, occurred in 32% and was significantly correlated with neuropathic pain (p=0.003). Neuropathic pain was significantly associated with poorer quality of life (p<0.001) and poorer hand function (p<0.001). Conclusion Almost one-fifth of all patients deal with neuropathic pain following RFFF harvest. Neuropathic pain is significantly correlated with poorer hand function and a poorer quality of life. Therefore, future research should focus on analyzing surgical factors such as the management of wound problems and primary denervation to improve hand function and quality of life of these patients.

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Section: Discussionmentioning

confidence: 92%

Neuropathic Donor-Site Pain following Radial Forearm Free Flap Harvest: A Multicenter Study on Incidence, Prognostic Factors, and Quality of Life

Bruin

Hundepool

Duraku³

et al. 2022

J Reconstr Microsurg

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“…Therefore, a longitudinal study would be more effective in that respect. In addition to the aforementioned predicting factors, side effects of cancer treatments (17,37,38), presence of dysphagia and hoarseness (39), tissue reconstruction undergone (34), tooth brushing and tooth loss (40) determine the QoL which was not considered in the present study among oral cancer survivors. Furthermore, our study was concentrated around the main cancer hospital in Sri Lanka where we expect to have good quality care for the survivors.…”

Section: Discussionmentioning

confidence: 99%

Health-related quality of life and its predicting factors among male oral cancer survivors in Sri Lanka: A cross sectional study

Fernando,

Weththasinghe,

Wanigasekara

et al. 2023

Galle Med J

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Introduction: Health-related quality of life (QoL) and its predicting factors for oral cancer survivors are varied and little evidence is available in Sri Lanka. This descriptive cross-sectional study aimed to assess the QoL and its predicting factors of male oral cancer survivors.Methods: The study was conducted at Apeksha Hospital (National Cancer Institute, Sri Lanka) from June to December 2018 for a period of six months. QoL of 295 oral cancer survivors was assessed using the WHOQoL-BREF questionnaire. The range of QoL score is from 0 to 100 and higher the score, higher the level of QoL Socio-demographic and disease-specific characteristics were considered as predicting factors for QoL and Multiple linear regression was performed to determine the predicting factors. The significant level was kept as p<0.05.Results: The mean score of QoL was averaged among all domains of WHOQoL-BREF questionnaire, which was depicted as 51.9±15, 52.3±19, 49.5±22 and 59.2±16 in Physical, Psychological, Social Relationship and Environment domains respectively. The number of years from diagnosis, metastasis, cancer stage and cancer site were the predictors of the physical health domain while employment status, metastasis, cancer stage and duration of betel chewing for the psychological domain (p<0.05). Age, education status, monthly income, metastasis, and duration of alcohol consumption were identified as the significant predictors of social relationships while employment, monthly income, metastasis, and duration of betel chewing were predictors of the environment domain (p<0.05).Conclusions: The study revealed that QoL of all domains were around average, but each QoL domain has different predicting factors. Therefore, consideration of these predicting factors are immensely helpful to enhance the QoL of these survivors.

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“…The main treatment methods and strategies are surgery, radiotherapy, chemotherapy, etc. but the 5-year survival rate of patients is still about 65%, and that of advanced patients is less than 30% 2,3 . With the progress of modern medicine, the mortality rate of oral squamous cell carcinoma has not decreased signi cantly.…”

Section: Introductionmentioning

confidence: 98%

Toosendanin induces apoptosis in Oral Squamous Cell Carcinoma cells through inhibition of p-STAT3 and inhibits tumor growth in a OSCC-PDX model

Wang

et al. 2022

Preprint

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BACKGROUND Toosendanin (TSN) has been found to inhibit the proliferation of different types of tumor cell lines. However, there is no data on the role of TSN in oral squamous cell carcinoma (OSCC). The purpose of this study was to evaluate the effects of TSN on OSCC cells in vitro, and to verify its effects on oral squamous cell carcinoma in vivo in a patient-derived xenograft (PDX) model. METHODS The effect of TSN on OSCC cells was investigated by cytotoxicity assays and flow cytometry. The expression of proteins was detected by Western blotting. An OSCC PDX model was constructed to further study the role of TSN in regulating the function of oral squamous cell carcinoma. RESULTS The cell viability of CAL-27 and HN-6 cells decreased gradually when the concentration of TSN increased from 0.025µM and 0.05µM to 0.1µM, and the apoptosis rate increased. Compared with the control group, the cytotoxic effect of TSN on CAL-27 and HN-6 cells was enhanced in a dose-dependent manner, and it could inhibit proliferation and induce apoptosis at lower doses. TSN can also induce apoptosis by inducing cell cycle arrest and regulating the expression of proteins such as STAT3. After successfully constructing an OSCC-PDX model with high pathological homology to the primary tumor and treated with intraperitoneal injection of TSN, The results showed that TSN could significantly reduce the tumor size of PDX model mice without obvious toxicity. CONCLUSIONS The in vivo experiments showed that TSN has a significant inhibitory effect on tumor growth, suggesting that it may be a promising drug for the treatment of oral squamous cell carcinoma. TSN may be an effective potential anticancer drug for the treatment of oral squamous cell carcinoma.

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Performance status scale for head and neck scores for oral cancer survivors: predictors and factors for improving quality of life

Abstract: Oral health care to increase optimal occlusal contacts and rehabilitation of trismus may be promising factors to improve the functional performance of oral cancer survivors.

Cited by 9 publications

References 23 publications

Neuropathic Donor-Site Pain following Radial Forearm Free Flap Harvest: A Multicenter Study on Incidence, Prognostic Factors, and Quality of Life

Neuropathic Donor-Site Pain following Radial Forearm Free Flap Harvest: A Multicenter Study on Incidence, Prognostic Factors, and Quality of Life

Health-related quality of life and its predicting factors among male oral cancer survivors in Sri Lanka: A cross sectional study

Toosendanin induces apoptosis in Oral Squamous Cell Carcinoma cells through inhibition of p-STAT3 and inhibits tumor growth in a OSCC-PDX model

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